Antifungal agent 143 is potent antifungal agent which also exihibits antibacterial activity. Antifungal agent 143 inhibits growth of Candida albicans and Aspergillus niger, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pyogenes. Antifungal agent 143 can be used for antimicrobial research [1].
In Vitro, Antifungal agent 143 (compound 4m) shows antifungal activity against Candida albicans (MIC = 50 μg/mL) and Aspergillus niger (MIC = 100 μg/mL), and antibacterial activity against Escherichia coli (MIC = 100 μg/mL), Pseudomonas aeruginosa (MIC = 100 μg/mL), Staphylococcus aureus (MIC = 250 μg/mL), and Streptococcus pyogenes (MIC = 50 μg/mL)[1].
References:
[1]. Jadhav CK, et al Efficient Rapid Access to Biginelli for the Multicomponent Synthesis of 1,2,3,4-Tetrahydropyrimidines in Room-Temperature Diisopropyl Ethyl Ammonium Acetate. ACS Omega. 2019 Dec 17;4(27):22313-22324.
In Vitro, Antifungal agent 143 (compound 4m) shows antifungal activity against Candida albicans (MIC = 50 μg/mL) and Aspergillus niger (MIC = 100 μg/mL), and antibacterial activity against Escherichia coli (MIC = 100 μg/mL), Pseudomonas aeruginosa (MIC = 100 μg/mL), Staphylococcus aureus (MIC = 250 μg/mL), and Streptococcus pyogenes (MIC = 50 μg/mL)[1].
References:
[1]. Jadhav CK, et al Efficient Rapid Access to Biginelli for the Multicomponent Synthesis of 1,2,3,4-Tetrahydropyrimidines in Room-Temperature Diisopropyl Ethyl Ammonium Acetate. ACS Omega. 2019 Dec 17;4(27):22313-22324.