15(S)-15-methyl Prostaglandin F2α has been shown to have potent uterine stimulant and abortifacient properties when
administered intramuscularly to induce labor.1,2 15(S)-15-methyl PGF2α ethyl amide is a lipophilic analog of 15(S)-15-methyl PGF2α methyl ester. Prostaglandin esters are generally hydrolyzed to the free acid upon in vivo administration, making the methyl esters useful prodrugs.3 Hydrolysis of prostaglandin amides in vivo is not thoroughly established.
1.Carlan, S.J., Gushwa, J.P., O'Brien, W.F., et al.Effect of intramuscular 15-methyl prostaglandin F2α after second-trimester deliveryObstet. Gynecol.895-9(1997)
2.Lindblom, B., KÄllfelt, B., Hahlin, M., et al.Local prostaglandin F2α injection for termination of ectopic pregnancyLancet776-777(1987)
3.Miller, W.L., and Sutton, M.J.Relative biological activity of certain prostaglandins and their enantiomersProstaglandins11(1)77-84(1976)
