A 1070722 |
| رقم الكتالوجGC10336 |
A 1070722 هو مثبط قوي وانتقائي للجليكوجين سينثاز كيناز 3 (GSK-3) ، مع Ki 0.6 نانومتر لكل من GSK-3α و GSK-3βيمكن لـ 1070722 أن يخترق الحاجز الدموي الدماغي (BBB) ويتراكم في مناطق الدماغ ، وبالتالي يحتمل أن يكون جهاز التتبع الإشعاعي PET لقياس كمية GSK-3 في الدماغ
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Cas No.: 1384424-80-9
Sample solution is provided at 25 µL, 10mM.
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A 1070722 is a potent and selective glycogen synthase kinase 3 (GSK-3) inhibitor, with a Ki of 0.6 nM for both GSK-3α and GSK-3β. A 1070722 can penetrate the blood-brain barrier (BBB) and accumulates in brain regions, thus potential for PET radiotracer for the quantification of GSK-3 in brain[1].
References:
[1]. Prabhakaran J, et al. Radiosynthesis and in Vivo Evaluation of [11C]A1070722, a High Affinity GSK-3 PET Tracer in Primate Brain. ACS Chem Neurosci. 2017 Aug 16;8(8):1697-1703.
| Cas No. | 1384424-80-9 | SDF | |
| Chemical Name | (Z)-N'-(7-methoxyquinolin-4-yl)-N-(6-(trifluoromethyl)pyridin-2-yl)carbamimidic acid | ||
| Canonical SMILES | COC1=CC2=NC=CC(/N=C(O)/NC3=CC=CC(C(F)(F)F)=N3)=C2C=C1 | ||
| Formula | C17H13F3N4O2 | M.Wt | 362.31 |
| الذوبان | <36.23mg/ml in DMSO | Storage | Store at RT |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.7601 mL | 13.8003 mL | 27.6007 mL |
| 5 mM | 0.552 mL | 2.7601 mL | 5.5201 mL |
| 10 mM | 0.276 mL | 1.38 mL | 2.7601 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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μL
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Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
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- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
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