AM9053 |
رقم الكتالوجGC81683
One-Click Copy Product Info
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AM9053 is a selective, effective and slowly reversible inhibitor of N-acyl ethanolamine acid amidease ( NAAA ) ( IC50 = 30 nM).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 157469-21-1
Sample solution is provided at 25 µL, 10mM.
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References:
[1]. Bottemanne P, et al. N-acylethanolamine hydrolyzing acid amidase inhibition: tools and potential therapeutic opportunities. Drug Discov Today. 2018 Aug;23(8):1520-1529.
[2]. Nanì MF, et al. Pharmacological Inhibition of N-Acylethanolamine Acid Amidase (NAAA) Mitigates Intestinal Fibrosis Through Modulation of Macrophage Activity. J Crohns Colitis. 2025 Feb 4;19(2):jjae132.
[3]. Romano B, et al. N-Acylethanolamine acid amidase (NAAA) is dysregulated in colorectal cancer patients and its inhibition reduces experimental cancer growth. Br J Pharmacol. 2022 Apr;179(8):1679-1694.
| Cas No. | 157469-21-1 | SDF | |
| Formula | C17H25NS | M.Wt | 275.45 |
| الذوبان | DMSO: 50 mg/mL (181.52 mM; Need ultrasonic) | Storage | Store at -20°C |
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.6304 mL | 18.1521 mL | 36.3042 mL |
| 5 mM | 726.1 μL | 3.6304 mL | 7.2608 mL |
| 10 mM | 363 μL | 1.8152 mL | 3.6304 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A liquid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)