BIX (Synonyms: BiP Inducer X) |
رقم الكتالوجGC50153
One-Click Copy Product Info
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BIX ، محفز انتقائي لبروتين ربط الغلوبولين المناعي ثقيل السلسلة (BiP) / GRP78 ، هو مثبط إجهاد ER (الشبكة الإندوبلازمية).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 101714-41-4
Sample solution is provided at 25 µL, 10mM.
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BiP (Hsp70-5) ER chaperone inducer; induces BiP expression in vitro and in vivo. Protects against ER-stress induced cell death in neuronal and retinal cell lines. Also protects against ischaemia-induced hippocampal cell death in vivo.
Inokuchi et al (2009) Effect of an inducer of BiP, a molecular chaperone, on endoplasmic reticulum (ER) stress-induced retinal cell death. Invest.Ophthalmol.Vis.Sci. 50 334 PMID:18757512 |Oida et al (2008) Induction of BiP, an ER-resident protein, prevents the neuronal death induced by transient forebrain ischemia in gerbil. Brain Res. 1208 217 PMID:18395193 |Kudo et al (2008) A molecular chaperone inducer protects neurons from ER stress. Cell Death Differ. 15 364 PMID:18049481
| Cas No. | 101714-41-4 | SDF | |
| المرادفات | BiP Inducer X | ||
| Canonical SMILES | O=C(CSC#N)C1=CC=C(O)C(O)=C1 | ||
| Formula | C9H7NO3S | M.Wt | 209.22 |
| الذوبان | DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 4.7797 mL | 23.8983 mL | 47.7966 mL |
| 5 mM | 955.9 μL | 4.7797 mL | 9.5593 mL |
| 10 mM | 478 μL | 2.3898 mL | 4.7797 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.50% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 12 reference(s) in Google Scholar.)