C18-Pyr-Cer is a chemically modified synthetic ceramide analog. C18-Pyr-Cer directly interacts with MAP1LC3B-I I. C18-Pyr-Cer induces autophagy, targets autolysosomes to mitochondria, and mediates lethal autophagy in cancer cells. C18-Pyr-Cer can be used in the research of head and neck squamous cell carcinoma [1].
In Vitro, C18-pyr-Cer induces autophagy and directs autolysosomes to mitochondria in human head and neck squamous cell carcinoma (HNSCC) cells[1].
References:
[1]. Deroyer C, et al. New role for EMD (emerin), a key inner nuclear membrane protein, as an enhancer of autophagosome formation in the C16-ceramide autophagy pathway. Autophagy. 2014 Jul;10(7):1229-40.
In Vitro, C18-pyr-Cer induces autophagy and directs autolysosomes to mitochondria in human head and neck squamous cell carcinoma (HNSCC) cells[1].
References:
[1]. Deroyer C, et al. New role for EMD (emerin), a key inner nuclear membrane protein, as an enhancer of autophagosome formation in the C16-ceramide autophagy pathway. Autophagy. 2014 Jul;10(7):1229-40.