CBA (Synonyms: CBA, Transient Receptor Potential Melastatin 4 Inhibitor 5, TRPM4 Inhibitor 5) |
| رقم الكتالوجGC50557 |
CBA (CBA) هو مثبط قوي وانتقائي لقناة الكاتيون TRPM4 ، مع IC50 1.5 μ ؛ M.
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Cas No.: 351424-20-9
Sample solution is provided at 25 µL, 10mM.
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Selective TRPM4 blocker (IC50 = 1.5 μM). Exhibits no significant activity against TRPM5, TRPM7, TRPM8, TRPV1, TRPV3, TRPV6 and a range of other ion channels and receptors. Displays neuroprotective effects against glutamate-induced neurodegeneration in vitro.
Bianchi et al (2018) The ion channel TRPM4 in murine experimental autoimmune encephalomyelitis and in a model of glutamate-induced neuronal degeneration. Mol.Brain. 11 41 PMID:29996905 |Ozhathil et al (2018) Identification of potent and selective small molecule inhibitors of the cation channel TRPM4. Br.J.Pharmacol. 175 2504 PMID:29579323
Average Rating: 5 (Based on Reviews and 27 reference(s) in Google Scholar.)
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