GLPBio

Chrysin

Catalog No.: GN10028Purity:>99.50%Synonyms: 5,7-DHF, 5,7-Dihydroxyflavone, NSC 407436
COASDSData Sheet
Chrysin is a natural flavonoid found in various plant extracts, honey, and propolis, possessing diverse biological activities, including anti-inflammatory, antioxidant, and anticancer effects.

المنتجات مخصصة للاستخدام البحثي فقط، وليست للاستخدام البشري. نحن لا نبيع للمرضى.

Chrysin
Cas No.: 480-40-0
10mM (in 1mL DMSO)In Stock
$35.00
1
20mgIn Stock
$77.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

المراجع (Citations)

لا تتوفر حاليًا مراجع لهذا المنتج. فيما يلي مجموعة مختارة من المنشورات التي تستشهد بمنتجات GlpBio.
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    632, 686–694 (2024)
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    Nature
    618, 1017–1023 (2023)
  • Nature cover
    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
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    388(6745) (2025)
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    387(6734) (2025)
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    31, 1291–1307 (2021)

الوصف (Description)

Chrysin is a natural flavonoid found in various plant extracts, honey, and propolis, possessing diverse biological activities, including anti-inflammatory, antioxidant, and anticancer effects[1, 2]. Chrysin can regulate drug resistance by inhibiting P-glycoprotein activity, thereby increasing the intracellular concentration of chemotherapeutic drugs such as paclitaxel[3].

In vitro, treatment of DU145 and PC-3 cells with Chrysin (0-100µM) for 48h induced apoptosis, evidenced by DNA fragmentation and an increase in the number of cells in the sub-G1 phase of the cell cycle in both DU145 and PC-3 cells[4]. Treatment of U937 cells with Chrysin (5-10µM) for 12h induced apoptosis and significantly induced the release of cytochrome c from mitochondria into the cytoplasm[5]. Treatment of human melanoma cells (SP6.5 and M17 cells) with Chrysin (0-100µM) for 12h reduced cell viability in a dose-dependent manner, with IC50 values of 28.3µM and 35.8µM for SP6.5 and M17 cells, respectively[6].

In vivo, oral administration of Chrysin (5, 10mg/kg) to mice with colitis for 7 days significantly improved the damage to the colonic tissue structure, reduced colonic myeloperoxidase (MPO) activity, and decreased the production of inflammatory mediators such as nitric oxide (NO), prostaglandin E2 (PGE2), and pro-inflammatory cytokines[7].

References:
[1] Zeinali M, Rezaee S A, Hosseinzadeh H. An overview on immunoregulatory and anti-inflammatory properties of chrysin and flavonoids substances[J]. Biomedicine & Pharmacotherapy, 2017, 92: 998-1009.
[2] Stompor-Gorący M, Bajek-Bil A, Machaczka M. Chrysin: Perspectives on contemporary status and future possibilities as pro-health agent[J]. Nutrients, 2021, 13(6): 2038.
[3] Panneerselvam S, Hussain S, Jeyavelkumaran R. Chrysin as a Chemosensitizer: Molecular Insights into Its Role in Prostate Cancer Treatment[J]. Journal of Bio-X Research, 2025, 2025: 0060.
[4] Ryu S, Lim W, Bazer F W, et al. Chrysin induces death of prostate cancer cells by inducing ROS and ER stress[J]. Journal of cellular physiology, 2017, 232(12): 3786-3797.
[5] Woo K J, Jeong Y J, Park J W, et al. Chrysin-induced apoptosis is mediated through caspase activation and Akt inactivation in U937 leukemia cells[J]. Biochemical and biophysical research communications, 2004, 325(4): 1215-1222.
[6] Xue C, Chen Y, Hu D N, et al. Chrysin induces cell apoptosis in human uveal melanoma cells via intrinsic apoptosis[J]. Oncology Letters, 2016, 12(6): 4813-4820.
[7] Shin E K, Kwon H S, Kim Y H, et al. Chrysin, a natural flavone, improves murine inflammatory bowel diseases[J]. Biochemical and biophysical research communications, 2009, 381(4): 502-507.

البروتوكول (Protocol)

Cell experiment [1]:

Cell lines

DU145、PC-3 cells

Preparation Method

DU145 and PC-3 cells (2×105 cells) were seeded on six-well plates and incubated for 24h in serum-free medium until cells reached 70–80% confluency. Then, cells were treated with 0, 5, 10, 20, 50, 100μM Chrysin for 48h at 37°C in a CO2 incubator. Supernatants were transferred from culture dishes into collecting tubes and adherent cells detached with trypsin-EDTA. The cells were collected by centrifugation, washed twice with cold PBS, and fixed with chilled 70% ethanol at 4°C overnight. Cells were then washed twice with PBS, incubated with 10mg/mL RNase A and 50mg/mL propidium iodide (PI) in PBS at room temperature for 30min in the dark and subjected to flow cytometry using a FACSCalibur.

Reaction Conditions

0, 5, 10, 20, 50, 100μM; 48h

Applications

Percentages of DU145 and PC-3 cells in the sub-G1 phase of the cell cycle increased with increasing concentrations of Chrysin.
Animal experiment [2]:

Animal models

BALB/c mice

Preparation Method

To induce experimental colitis, we treated the mice for 7 days with 5% DSS dissolved in filter-purified water. The control mice received filtered water alone. Chrysin was dissolved in dimethyl sulfoxide (DMSO) and was freshly diluted in corn oil. Chrysin (1, 5, or 10mg/kg of body weight) or the vehicle (PBS with DMSO) was administrated orally for 7days, beginning in coordination with the start of dextran sodium sulfate (DSS) exposure. Assessment of DSS-induced colitis. The mice were assessed daily for the development of colitis based on body weight, gross rectal bleeding, stool consistency, and survival. Overall disease severity was assessed using a clinical scoring system with a scale of 0-4.

Dosage form

1, 5, 10mg/kg; 7 days; p.o.

Applications

A significant blunting of weight loss and clinical signs was observed in DSS-exposed, Chrysin-treated mice when compared to vehicle-treated mice. This was associated with a remarkable amelioration of the disruption of the colonic architecture, a significant reduction in colonic myeloperoxidase (MPO) activity, and a decrease in the production of inflammatory mediators such as nitric oxide (NO), prostaglandin (PG) E2, and pro-inflammatory cytokines.

References:
[1] Ryu S, Lim W, Bazer F W, et al. Chrysin induces death of prostate cancer cells by inducing ROS and ER stress[J]. Journal of cellular physiology, 2017, 232(12): 3786-3797.
[2]Shin E K, Kwon H S, Kim Y H, et al. Chrysin, a natural flavone, improves murine inflammatory bowel diseases[J]. Biochemical and biophysical research communications, 2009, 381(4): 502-507.

وثائق المنتج (Product Documents)

Purity:>99.50%Appearance:A solid
COASDSData Sheet

الخصائص الكيميائية (Chemical Properties)

رقم CAS
480-40-0
المرادفات
5,7-DHF, 5,7-Dihydroxyflavone, NSC 407436
الاسم الكيميائي
5,7-dihydroxy-2-phenylchromen-4-one
SMILES
C1=CC=C(C=C1)C2=CC(=O)C3=C(C=C(C=C3O2)O)O
الصيغة الجزيئية
C15H10O4
الوزن الجزيئي
254.24
الذوبانية
≥ 12.4mg/mL in DMSO
التخزين
Store at 2-8°C
إرشادات عامة
اختر مذيبًا مناسبًا وفقًا لبيانات ذوبانية المنتج. بعد التحضير، قسّم المحلول المخزون إلى أجزاء لتجنب دورات التجميد والذوبان المتكررة.
استخدم المحاليل المخزونة خلال 6 أشهر عند حفظها في -80°C، أو خلال شهر واحد عند حفظها في -20°C.
لتحسين الذوبانية، سخّن الأنبوب إلى 37°C وعرّضه للموجات فوق الصوتية لمدة مناسبة.
شروط الشحن
تُشحن عينات التقييم مع عبوات تبريد. وتُشحن الأحجام الأخرى المتاحة في درجة حرارة الغرفة، أو مع عبوات تبريد عند الطلب.

الحاسبات (Calculators)المولارية / التخفيف / الوزن الجزيئي / تحويل الوحدات / تركيبة داخل الجسم الحي / الذوبانية

g/mol

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