Col003 |
| رقم الكتالوجGC34539 |
Col003 هو مثبط انتقائي وقوي لـ Hsp47 ويرتبط بشكل تنافسي بموقع ربط الكولاجين على Hsp47 (IC50 = 1.8 ميكرومتر)
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Cas No.: 328565-16-8
Sample solution is provided at 25 µL, 10mM.
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Col003 is a potent inhibitor of Hsp47, competitively binds to the collagen binding site on Hsp47 (IC50, 1.8 μM), and inhibits collagen secretion by destabilizing the collagen triple helix[1]. HSP47|1.8 μM (IC50)
[1]. Ito S, et al. A small-molecule compound inhibits a collagen-specific molecular chaperone and could represent a potential remedy for fibrosis. J Biol Chem. 2017 Dec 8;292(49):20076-20085.
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