Edicotinib (Synonyms: JNJ-40346527; JNJ-527) |
| رقم الكتالوجGC19418 |
Edicotinib (JNJ-40346527) هو مثبط عامل -1 (CSF-1R) فعّال وانتقائي ومخترق للدماغ ونشط عن طريق الفم مع عامل IC50 يبلغ 3.2 نانومتر
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Cas No.: 1142363-52-7
Sample solution is provided at 25 µL, 10mM.
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Edicotinib is a selective and orally available colony-stimulating factor-1 (CSF-1) receptor inhibitor, and has entered phase IIA clinical trial to study rheumatoid arthritis (RA) despite disease.
[1]. Genovese MC, et al. Results from a Phase IIA Parallel Group Study of JNJ-40346527, an Oral CSF-1R Inhibitor, in Patients with Active Rheumatoid Arthritis despite Disease-modifying Antirheumatic Drug Therapy. J Rheumatol. 2015 Oct;42(10):1752-60.
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