ENPP3 inhibitor 4t is an inhibitor of ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (ENPP3; IC50 = 0.15 µM).1 It is selective for ENPP3 over ENPP1 (IC50 = 41.4 µM).
1.Ullah, S., Pelletier, J., SÉvigny, J., et al.Synthesis and biological evaluation of arylamide sulphonate derivatives as ectonucleotide pyrophosphatase/phosphodiesterase-1 and -3 inhibitorsACS Omega7(30)26905-26918(2022)