Other Signal Transduction

GATA4-NKX2-5-IN-1 (3i-1000) is a small-molecule compound inhibiting GATA4 and NKX2-5 transcriptional synergy with IC50 of 3 uM

Panx-1 mimetic inhibitory peptide, blocks pannexin-1 gap junctions

مثبط لتحلل الغشاء الخلوي المرتبط بالشبكة الإندوبلازمية ونقل البروتين.

10Panx is a potent Panx1 channel inhibitor that targets the W74 to Y83 segment of the ECL1 of Panx1 protein.

Levetiracetam ، وهو عامل مضاد للصرع ، يربط بروتين الحويصلة المشبكية SV2A

يعد BLU-782 مثبطا نشطا فمويا للكيناز شبيه مستقبل الأكتيفين 2 (ALK2)، يقيم تركيز تشبيط IC 50 تبلغ 0.2nM، 0.6nM، و3nM، و24nM، و45nM، و65nM، و155nM تجاه ALK2 R206H ، وALK2، وALK1، وALK6، وALK3، وALK4، وALK5 على التوالي.

M2N12 هو مثبط فوسفاتيز بروتيني 25C (Cdc25C) فعال وعالي الانتقائية لدورة انقسام الخلايا مع قيمة IC50 تبلغ 0.09 ميكرومتريحتوي M2N12 أيضًا على نشاط واعد ضد Cdc25A و Cdc25B بقيم IC50 0.53 ميكرومتر و 1.39 ميكرومتر على التواليM2N12 له نشاط مضاد للورم ويمكن استخدامه لأبحاث السرطان

LP-935509 هو مثبط فعال عن طريق الفم وانتقائي ومنافس للأدينوزين ثلاثي الفوسفات (ATP) وذو قدرة اختراق للدماغ، لبروتين المحول المهاجر 2 المرتبط بالأدابتور كيناز 1 (AAK1) بـ IC50 يبلغ 3.3 نانومتر و Ki يبلغ 0.9 نانومتر على التوالي.

Decursinol angelate is a pyranocoumarin that has been found in the Korean medicinal herb A.

Compound 43 TAO kinase inhibitor is an ATP-competitive inhibitor of the thousand-and-one amino acid kinases TAOK1 and TAOK2 (IC50s = 11 and 15 nM, respectively).

Protein kinase D (PKD) is a serine/threonine protein kinase that is activated by diacylglycerol, commonly downstream of PKC signaling.

D-myo-inositol-1,2,3,5,6-pentaphosphate (Ins(1,2,3,5,6)-P5) (sodium salt) is produced from Ins(1,2,3,4,5,6)P6 via a minor enzymatic phytate degradation pathway by K.

D-myo-Inositol-1,2,3,5-tetraphosphate (Ins(1,2,3,5)P4) is one of the many inositol phosphate isomers that could act as small, soluble second messengers in the transmission of cellular signals.

D-myo-Inositol-1,2,4,5,6-pentaphosphate (sodium salt) (Ins(1,2,4,5,6)P5 (sodium salt)) is one of several different inositol oligophosphate isomers implicated in signal transduction.

Ins(1,2,4,5)P4 is one of the many inositol phosphate (InsP) isomers that act as small, soluble second messengers in the transmission of cellular signals..

D-myo-Inositol-1,2,6-phosphate (Ins(1,2,6)-P3) is a member of the inositol phosphate (InsP) family of second messengers that play a critical role in the transmission of cellular signals.

The phosphatidylinositol 3-kinase (PI3K)/Akt signal transduction pathway plays critical roles in cell growth and proliferation making it an attractive target for anticancer agents.

The inositol phosphates play a critical role as small, soluble second messengers in transmission of cellular signals.

D-myo-Inositol-1,3,5-phosphate (Ins(1,3,5)P3) is a member of the inositol phosphate (InsP) family of second messengers that play a critical role in the transmission of cellular signals.

D-myo-Inositol-1,4-phosphate (Ins(1,4)P2) is a member of the inositol phosphate (InsP) molecular family that play critical roles as small, soluble second messengers in the transmission of cellular signals.

D-myo-Inositol-1,5-phosphate (Ins(1,5)P) is a member of the inositol phosphate (InsP) molecular family that play critical roles as small, soluble second messengers in the transmission of cellular signals.

D-myo-Inositol-1-phosphate (Ins(1)P1) is a member of the inositol phosphate molecular family of second messengers that play critical roles in intracellular signaling.

D-myo-Inositol-1-phosphate (Ins(1)P1) is a member of the inositol phosphate (InsP) molecular family of second messengers that play a critical role in the transmission of cellular signals.

D-myo-inositol-2,3,5,6-tetraphosphate (sodium salt) (Ins(2,3,5,6)-P4 (sodium salt)) is produced from Ins(1,2,3,5,6)P5 via a minor enzymatic phytate degradation pathway by K.