FCE 28654 |
| رقم الكتالوجGC31384 |
FCE 28654 هو مثبط لـ acylCoA: الكوليسترول أسيل ترانسفيراز (ACAT) ، يثبط بشكل ضعيف ACAT في الميكروسومات من الشريان الأورطي الأرانب والأمعاء ، وكبد القرد ، مع IC50s من 2.55 ، 1.08 و 5.69 ميكرومتر ، على التوالي
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Cas No.: 169474-77-5
Sample solution is provided at 25 µL, 10mM.
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FCE 28654 is a water soluble inhibitor of acylCoA: cholesterol acyltransferase (ACAT), weakly inhibiting ACAT in microsomes from rabbit aorta and intestine, and monkey liver, with IC50s of 2.55, 1.08 and 5.69 μM, respcetively.
FCE 28654 is an inhibitor of ACAT, weakly inhibiting ACAT in microsomes from rabbit aorta and intestine, and monkey liver, with IC50s of 2.55, 1.08 and 5.69 μM, respcetively[1].
FCE 28654 (15 mg/kg, p.o.) dramatically decreases blood cholesterol and modifies the hepatic cholesterol pattern via enhancing the free/esterified cholesterol ratio, in hypercholesterolemic rats. FCE 28654 (100 mg/kg, p.o.) also reduces microsomal ACAT activity rat plasma[1].
[1]. A.Chiari, et al. Synthesis and pharmacological profile of FCE 28654: A water-soluble and injectable ACAT inhibitor. Bioorganic & Medicinal Chemistry Letters. 1995 Aug 3;5(15):1581-1586.
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