c-met-IN-1 |
رقم الكتالوجGC35717 |
c-met-IN-1 (المركب 16) هو مثبط c-Met قوي وانتقائي ، مع IC 50 من 1.1 نانومتر ، مع نشاط مضاد للأورام .
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Cas No.: 2084836-84-8
Sample solution is provided at 25 µL, 10mM.
c-met-IN-1 (compound 16) is a potent and selective c-Met inhibitor, with IC50 of 1.1 nM, with antitumor activity.[1]. IC50: 1.1 nM (c-Met)[1]
c-met-IN-1 (compound 16) exhibits high selectivity and remarkable cytotoxicity against HT-29, MKN-45 and A549 cells with IC50 values of 0.08 μM, 0.22 μM and 0.07 μM, respectively[1].
[1]. Wang X, et al. Design, synthesis and biological evaluation of novel 4-(2-fluorophenoxy)quinoline derivatives as selective c-Met inhibitors. Bioorg Med Chem. 2017 Feb 1;25(3):886-896.
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(Based on Reviews and 13 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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