HSD1590 |
| رقم الكتالوجGC60193 |
HSD1590 هو مثبط قوي لـ ROCK ، مع IC50s من 1.22 و 0.51 نانومتر لـ ROCK1 و ROCK2 ، على التوالييعرض HSD1590 ارتباطًا نانويًا أحادي الرقم مع ROCK (Kds <2 نانومتر)يعرض HSD1590 سمية خلوية منخفضة
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2379279-96-4
Sample solution is provided at 25 µL, 10mM.
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HSD1590 is potent ROCK inhibitor, with IC50s of 1.22 and 0.51 nM for ROCK1 and ROCK2, respectively. HSD1590 exhibits single digit nanomolar binding to ROCK (Kds<2 nM). HSD1590 displays low cytotoxicity[1].
HSD1590 (0.5-1 µM; 24 hours) exhibits an impressive attenuation in migration[1].HSD1590 (0.5-10 µM; 12-24 horus) shows that the excellent migration inhibition observed is not due to cell death, but inhibition of live cell migration[1]. Cell Viability Assay[1] Cell Line: MDA-MB-23 cells
[1]. Dayal N, et al. Potently inhibiting cancer cell migration with novel 3H-pyrazolo[4,3-f]quinoline boronic acid ROCK inhibitors. Eur J Med Chem. 2019 Oct 15;180:449-456.
Average Rating: 5 (Based on Reviews and 2 reference(s) in Google Scholar.)
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