MitoBloCK-10 |
| رقم الكتالوجGC61070 |
MitoBloCK-10 (MB-10) هو أول مُعدِّل جزيء صغير لتخفيف النشاط المركب للمحرك المرتبط بالبروتين (PAM)
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 394694-98-5
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
MitoBloCK-10 (MB-10) is the first small molecule modulator to attenuate protein-associated motor (PAM) complex activity. MitoBloCK-10 (MB-10) inhibits Tim44 (C-terminal domain) binding to the precursor and to Hsp70[1].
MB-10 (100 μM) is a potential attenuator of protein import into mitochondria[1].MB-10 inhibits the import of substrates that use the TIM23 import pathway[1].MB-10 (0-100 μM) inhibits protein import into mammalian mitochondria[1]. Cell Viability Assay[1] Cell Line: A plasmid expressing Su9-Ura3-myc was integrated at the LEU2 locus in WT and tim23-2 strains.
[1]. Non Miyata, et al. Adaptation of a Genetic Screen Reveals an Inhibitor for Mitochondrial Protein Import Component Tim44. J Biol Chem. 2017 Mar 31;292(13):5429-5442.
Average Rating: 5 (Based on Reviews and 26 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *