ICCB280 |
| رقم الكتالوجGC61414 |
ICCB280 هو محفز قوي لـ C / EBPαيُظهر ICCB280 خصائص مضادة لسرطان الدم بما في ذلك التمايز النهائي ، وتوقيف الانتشار ، وموت الخلايا المبرمج من خلال تنشيط C / EBPα والتأثير على أهدافه النهائية (مثل C / EBPε و G-CSFR و c-Myc)
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2041072-41-5
Sample solution is provided at 25 µL, 10mM.
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ICCB280 is a potent inducer of C/EBPα. ICCB280 exhibits anti-leukemic properties including terminal differentiation, proliferation arrest, and apoptosis through activation of C/EBPα and affecting its downstream targets (such as C/EBPε, G-CSFR and c-Myc)[1][2].
ICCB280 (0.1-50 μM; 48 h) suppresses the HL-60 cell growth, with an IC50 of 8.6 μM[1].ICCB280 (10 μM; 2-8 d) increases the C/EBPα expression (mRNA and protein) and modulates its target genes in HL-60 cells[1].ICCB280 (10 μM; 7 d) induces granulocytic differentiation and subsequent apoptosis in HL-60 cells[1]. Cell Viability Assay[1] Cell Line: HL-60 cells
[1]. Radomska HS, et, al. A Cell-Based High-Throughput Screening for Inducers of Myeloid Differentiation. J Biomol Screen. 2015 Oct;20(9):1150-9. [2]. Sridhar R, et, al. Styryl Quinazolinones as Potential Inducers of Myeloid Differentiation via Upregulation of C/EBPα. Molecules. 2018 Aug 3;23(8):1938.
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