Synucleozid (Synonyms: NSC 377363) |
| رقم الكتالوجGC39510 |
سينوكليوزيد (NSC 377363) هو مثبط قوي لـ SNCA? mRNA الذي يشفر بروتين ألفا-سينوكلين (IC50 = 1.5 مم).
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Cas No.: 502139-01-7
Sample solution is provided at 25 µL, 10mM.
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Synucleozid (NSC 377363) is a potent inhibitor of the SNCA mRNA that encodes α-synuclein protein (IC50=1.5 μM). Synucleozid selectively targets the α-synuclein mRNA 5′ UTR at the designed IRE site, decreases the amount of SNCA mRNA loaded into polysomes and thereby inhibits SNCA translation. Synucleozid has the potential for the investigation of Parkinson's disease[1].
[1]. Zhang P, et al. Translation of the intrinsically disordered protein α-synuclein is inhibited by a small molecule targeting its structured mRNA.Proc Natl Acad Sci U S A. 2020 Jan 21;117(3):1457-1467.
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