IP3RCYT is an IP 3 R inhibitory peptide, which can inhibit the binding of cytochrome C to IP 3 R with an IC50 about 100 nM. IP3RCYT regulates calcium signaling within cells. P3RCYT inhibits apoptosis in HeLa and Jurkat cells treated with Staurosporine or Membrane-bound Fas ligand (FasL) [1].
References:
[1]. Boehning D, et al. A peptide inhibitor of cytochrome c/inositol 1,4,5-trisphosphate receptor binding blocks intrinsic and extrinsic cell death pathways. Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1466-71.
References:
[1]. Boehning D, et al. A peptide inhibitor of cytochrome c/inositol 1,4,5-trisphosphate receptor binding blocks intrinsic and extrinsic cell death pathways. Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1466-71.