IP3RPEP6 is an IP 3 R competitive inhibitor. IP3RPEP6 has the IC50 values of 9.0 μM, 3.9 μM and 4.3 μM for IP 3 R1, IP 3 R2 and IP 3 R3, respectively. IP3RPEP6 does not affect the Ryanodine receptor and Cx43 hemichannels. IP3RPEP6 regulates calcium signaling within cells [1].
References:
[1]. Tao S, et al. IP3RPEP6, a novel peptide inhibitor of IP3 receptor channels that does not affect connexin-43 hemichannels. Acta Physiol (Oxf). 2024 Mar;240(3):e14086.
References:
[1]. Tao S, et al. IP3RPEP6, a novel peptide inhibitor of IP3 receptor channels that does not affect connexin-43 hemichannels. Acta Physiol (Oxf). 2024 Mar;240(3):e14086.