GLPBio

Iron dextran

Catalog No.: GC60940Purity:>98.00%
COASDSData Sheet
يمكن استخدام ديكستران الحديد (Fe dextran) في دراسة فقر الدم الناجم عن نقص الحديد في الحيوانات

المنتجات مخصصة للاستخدام البحثي فقط، وليست للاستخدام البشري. نحن لا نبيع للمرضى.

Iron dextran
Cas No.: 9004-66-4
25 mLIn Stock
$115.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

المراجع (Citations)

لا تتوفر حاليًا مراجع لهذا المنتج. فيما يلي مجموعة مختارة من المنشورات التي تستشهد بمنتجات GlpBio.
  • Nature cover
    Nature
    641, 529–536 (2025)
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    Nature
    628, 630–638 (2024)
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    Nature
    632, 686–694 (2024)
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    Nature
    618, 1017–1023 (2023)
  • Nature cover
    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
  • Science cover
    Science
    388(6745) (2025)
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    Science
    387(6739) (2025)
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    Science
    387(6734) (2025)
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    Cell Research
    35, 97–116 (2025)
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    34, 683–706 (2024)
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    33, 546–561 (2023)
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    Cell Research
    33, 904–922 (2023)
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    Cell Research
    31, 1291–1307 (2021)

الوصف (Description)

Iron dextran is an injectable complex comprising ferric hydroxide and a low-molecular-weight fraction of dextran. Iron dextran is a type of intravenous iron agent specifically used for the treatment of iron deficiency anemia[1].

In vitro, Iron dextran(1.9–4000μg/ml; 24h) exhibited certain cytotoxicity to HepG2 cells, with a half - inhibitory concentration (IC50) of 1178μg/ml. When used in combination with TQ (thymoquinone), TQ at a specific dose would enhance its toxicity[2].

In vivo, Iron dextran (200mg/kg/every other day; 1,2,3 or 4 weeks; i.p.) induces iron overload and CTSB/CTSD up-regulation in the liver and spleen of mice[3]. Iron dextran (0, 1.1, 3.3 and 9.9mg/(100g·bw·d); 4 weeks; i.g.) played an important role in improving iron deficiency anemia, promoting vitamin D metabolism and activation, regulating iron metabolism balance, and promoting growth and development in rats[4].

References:
[1] Failla S, Nicolas S, Parmar M. Iron Dextran. 2024 Feb 15. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–.
Failla S, Nicolas S, Parmar M. Iron Dextran. 2024 Feb 15. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–. PMID: 32491679.
[2] Ghasemi F, Ghaffari F, Omidifar N, Taheri Azandaryani M, Nili-Ahmadabadi A. Hepatic Response to the Interaction Between Thymoquinone and Iron-Dextran: an In Vitro and In Vivo Study. Biol Trace Elem Res. 2023 Mar;201(3):1358-1367.
[3] Liang M, Chen L, He Q, Mi X, Qu L, Xie J, Song N. Intraperitoneal injection of iron dextran induces peripheral iron overload and mild neurodegeneration in the nigrostriatal system in C57BL/6 mice. Life Sci. 2023 May 1;320:121508.
[4] Qiu F, Li R, Gu S, Zhao Y, Yang L. The effect of iron dextran on vitamin D3 metabolism in SD rats. Nutr Metab (Lond). 2022 Jul 16;19(1):47.

البروتوكول (Protocol)

Cell experiment [1]:

Cell lines

HepG2 cells

Preparation Method

The HepG2 cell line was cultured in 25cm² flasks containing HG-DMEM medium supplemented with 1% penicillin-streptomycin and 10% fetal bovine serum. The cells were maintained in a humidified atmosphere of 5% CO₂ at 37°C. For cytotoxicity experiments, HepG2 cells were seeded at a density of 10,000 viable cells per well in sterile 96-well plates and incubated overnight at 37°C and 5% CO₂. In the first step, the cells were treated with different concentrations of TQ (0.5-300×10³nM) and Iron dextran (1.9-4000µg/ml) for 24 hours, and the cell viability was determined using the MTT method separately. In the next step, HepG2 cells were pretreated with safe doses of TQ (1.8-15×10³nM) before being exposed to various concentrations of Iron dextran. After 24 hours, 0.5mg/ml of MTT reagent was added to each well and incubated for 4 hours. Finally, 100µl of dimethyl sulfoxide (DMSO) was added to each well to dissolve the formazan crystals, and the changes in absorbance were measured at 570nm using a microplate reader.

Reaction Conditions

1.9-4000µg/ml; 24h

Applications

Iron dextran exhibited certain cytotoxicity to HepG2 cells, with a half - inhibitory concentration (IC50) of 1178μg/ml. When used in combination with TQ (thymoquinone), TQ at a specific dose would enhance its toxicity.

Animal experiment [2]:

Animal models

8-week-old male C57BL/6

Preparation Method

Eight-week-old mice were housed in a near pathogen-free environment (temperature 20°C ± 2°C, humidity 50%–60%, 12h light/dark cycle), with four animals per polypropylene cage and food and water provided ad libitum. Mice were intraperitoneally injected with 200mg/kg Iron dextran every other day for 1, 2, 3, or 4 weeks. Control mice were injected with the same amount of saline.

Dosage form

200mg/kg; 1, 2, 3, or 4 weeks; i.p.

Applications

Iron dextran induces iron overload and CTSB/CTSD up-regulation in the liver and spleen of mice.

References:
[1] Ghasemi F, Ghaffari F, Omidifar N, Taheri Azandaryani M, Nili-Ahmadabadi A. Hepatic Response to the Interaction Between Thymoquinone and Iron-Dextran: an In Vitro and In Vivo Study. Biol Trace Elem Res. 2023 Mar;201(3):1358-1367.
[2] Liang M, Chen L, He Q, Mi X, Qu L, Xie J, Song N. Intraperitoneal injection of iron dextran induces peripheral iron overload and mild neurodegeneration in the nigrostriatal system in C57BL/6 mice. Life Sci. 2023 May 1;320:121508.

وثائق المنتج (Product Documents)

Purity:>98.00%Appearance:A solution in water
COASDSData Sheet

الخصائص الكيميائية (Chemical Properties)

رقم CAS
9004-66-4
SMILES
[Iron dextran]
الذوبانية
Iron, ~100 mg/mL in water
التخزين
Store at -20°C
إرشادات عامة
اختر مذيبًا مناسبًا وفقًا لبيانات ذوبانية المنتج. بعد التحضير، قسّم المحلول المخزون إلى أجزاء لتجنب دورات التجميد والذوبان المتكررة.
استخدم المحاليل المخزونة خلال 6 أشهر عند حفظها في -80°C، أو خلال شهر واحد عند حفظها في -20°C.
لتحسين الذوبانية، سخّن الأنبوب إلى 37°C وعرّضه للموجات فوق الصوتية لمدة مناسبة.
شروط الشحن
تُشحن عينات التقييم مع عبوات تبريد. وتُشحن الأحجام الأخرى المتاحة في درجة حرارة الغرفة، أو مع عبوات تبريد عند الطلب.

الحاسبات (Calculators)المولارية / التخفيف / الوزن الجزيئي / تحويل الوحدات

g/mol

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