JNJ-27390467 is a potent, orally active, and selective tryptase inhibitor ( human β-tryptase IC50 = 3.6 nM, K i = 3.7 nM). JNJ-27390467 exhibits excellent selectivity over trypsin of ~5000-fold. JNJ-27390467 shows effects in animal models of airway inflammation. JNJ-27390467 can be used for allergic asthma research [1].
References:
[1]. Costanzo MJ, et al. Potent, nonpeptide inhibitors of human mast cell tryptase. Synthesis and biological evaluation of novel spirocyclic piperidine amide derivatives. Bioorg Med Chem Lett. 2008 Mar 15;18(6):2114-21.
References:
[1]. Costanzo MJ, et al. Potent, nonpeptide inhibitors of human mast cell tryptase. Synthesis and biological evaluation of novel spirocyclic piperidine amide derivatives. Bioorg Med Chem Lett. 2008 Mar 15;18(6):2114-21.