LCAHA (Synonyms: LCA hydroxyamide) |
| رقم الكتالوجGC62460 |
LCAHA (LCA hydroxyamide) هو مثبط deubiquitinase USP2a مع IC50s من 9.7 ميكرومتر و 3.7 ميكرومتر في Ub-AMC Assay و Di-Ub Assay ، على التوالييزعزع LCAHA استقرار Cyclin D1 ويحث على توقيف G0 / G1 عن طريق تثبيط deubiquitinase USP2a
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Cas No.: 117094-40-3
Sample solution is provided at 25 µL, 10mM.
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LCAHA (LCA hydroxyamide) is a deubiquitinase USP2a inhibitor with IC50s of 9.7 μM and 3.7μM in Ub-AMC Assay and Di-Ub Assay, respectively. LCAHA destabilizes Cyclin D1 and induces G0/G1 arrest by inhibiting deubiquitinase USP2a[1].
LCAHA inhibits HCT116wt and HCT116 p53-/- colon cancer cells viability with GI50s of 0.87±0.09 and 0.96±0.29μM, respectively, and the LD50s of 27.8±3.9 and 26.5±0.1μM, respectively[1].
[1]. Katarzyna Magiera, et al. Lithocholic Acid Hydroxyamide Destabilizes Cyclin D1 and Induces G 0/G1 Arrest by Inhibiting Deubiquitinase USP2a. Cell Chem Biol. 2017 Apr 20;24(4):458-470.e18.
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