Cyclooxygenase

Prostaglandin D2 (PGD2) is one of the five primary enzymatic prostaglandins derived directly from PGH2.

11β-PGF1β is the stereoisomer of PGF1α with both C-9 and C-11 hydroxyls inverted.

13,14-dihydro Prostaglandin E1 (13,14-dihydro PGE1) is a biologically active metabolite of PGE1 with comparable potency to the parent compound.

13,14-dihydro Prostaglandin F2α (13,14-dihydro PGF2α) is the analog of PGF2α which has no unsaturation in the lower side chain.

13,14-dihydro-15(R)-Prostaglandin E1 (13,14-dihydro-15(R)-PGE1) is an analog of 13,14-dihydro-PGE1 , which has the hydroxyl group at C-15 in the unnatural R configuration.

13,14-dihydro-15-keto Prostaglandin F1α (13,14-dihydro-15-keto PGF1α) is a metabolite of PGF1α that has been reported in the rat stomach.

15(R)-15-methyl PGF2α is a metabolically stable analog of PGF2α.

16-phenoxy tetranor PGE2 is the free acid form of sulprostone formed by the hydrolysis of the methylsulfonamide bond.

19(R)-Hydroxylated prostaglandins occur in μg/ml concentrations in the semen of certain mammalian species, especially primates.

19(R)-hydroxy Prostaglandin E2 (19(R)-hydroxy PGE2) is found in the semen of primates, including man.

20-hydroxy Prostaglandin E2 (20-hydroxy PGE2) is a product of cytochrome P450 metabolism of PGE2.

Thromboxane B3 (TXB3) is the stable hydrolysis product of TXA3 synthesized from eicosapentaenoic acid by COX and thromboxane synthase.

δ17-6-keto Prostaglandin F1α (δ17-6-keto PGF1α) is a cyclooxygenase (COX) product of eicosapentaenoic acid (EPA) in various tissues such as seminal vesicles, lung, Polymorphonuclear leukocytes, and ocular tissues.

15-keto Iloprost is the C-15 oxidized derivative of iloprost, a second generation structural analog of prostaglandin I2 (prostacyclin).

Prostaglandin E2 (PGE2), one of the most widely investigated PGs, can be used as a biomarker of inflammation, disease state, or therapeutic effectiveness.

Prostaglandin D2 (PGD2) plays a pharmacological role in allergic and asthmatic anaphylaxis, normal physiological sleep and lowering of body temperature, as well as inhibits platelet aggregation and relaxes vascular smooth muscle.

15(S)-Fluprostenol isopropyl ester (15(S)-Flu-Ipr) is the unnatural C-15 epimer of Travoprost.

Travoprost is the Alcon trade name for fluprostenol isopropyl ester, an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug.

Jacaric acid is a conjugated polyunsaturated fatty acid first isolated from seeds of Jacaranda plants.

Butaprost is a structural analog of prostaglandin E2 (PGE2) with good selectivity for the EP2 receptor subtype.

S-BINOL is a chiral auxiliary for asymmetric ketone reduction, in particular 15-keto prostaglandin intermediates to 15(S)-alcohols.

AL 8810 is an 11β-fluoro analog of PGF2α which acts as a potent and selective antagonist at the FP receptor.

1-(6-Methoxy-2-naphthyl)ethanol is a potential impurity in commercial preparations of naproxen.

11-dehydro TXB3 is a urinary metabolite of TXA3 in humans with enhanced dietary intake of EPA.