Jacaric Acid (Synonyms: 8(Z),10(E),12(Z)-Octadecatrienoic Acid) |
| رقم الكتالوجGC41645 |
Jacaric acid is a conjugated polyunsaturated fatty acid first isolated from seeds of Jacaranda plants.
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Cas No.: 28872-28-8
Sample solution is provided at 25 µL, 10mM.
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Jacaric acid is a conjugated polyunsaturated fatty acid first isolated from seeds of Jacaranda plants. Structurally, it is an 18-carbon ω-6 triene isomer of γ-linolenic acid . Jacaric acid induces cell cycle arrest and apoptosis in a variety of cancer cell lines (GI50 = 1-5 µM). It increases the production of reactive oxygen species, and cytotoxicity is abolished by the antioxidant α-tocopherol, suggesting that apoptosis results from oxidative stress. Jacaric acid is metabolized in vivo to conjugated linoleic acid , which is also cytotoxic to cancer cells. Jacaric acid inhibits cyclooxygenase-1 in vitro (Ki = 1.7 µM) and, with long term feeding, decreases stearoyl-CoA desaturase expression and activity in mice.
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