MC3482 |
| رقم الكتالوجGC34431 |
يعد MC3482 مثبطًا محددًا لـ sirtuin5 (SIRT5)
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Sample solution is provided at 25 µL, 10mM.
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MC3482 is a specific sirtuin5 (SIRT5) inhibitor.
MC3482 inhibits sirtuin5. 50 μM MC3482 inhibits SIRT5 desuccinylating activity without affecting SIRT5 intracellular expression levels. Autophagy and mitophagy increase in SIRT5-silenced cells and in WT cells treated with MC3482 and decrease in SIRT5-overexpressing cells[1].
[1]. Polletta L, et al. SIRT5 regulation of ammonia-induced autophagy and mitophagy. Autophagy. 2015;11(2):253-70.
Average Rating: 5 (Based on Reviews and 35 reference(s) in Google Scholar.)
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