Metaxalone-d6 (Synonyms: AHR438-d6; NSC170959-d6) |
رقم الكتالوجGC48907
One-Click Copy Product Info
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An internal standard for the quantification of metaxalone
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1189944-95-3
Sample solution is provided at 25 µL, 10mM.
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Metaxalone-d6 is intended for use as an internal standard for the quantification of metaxalone by GC-or LC-MS. Metaxalone is a skeletal muscle relaxant.1,2 It inhibits the proliferation of, and induces apoptosis in, RAW 264.7 cells in vitro when used at concentrations ranging from 1 to 100 µM.2 Metaxalone also reduces LPS-induced increases in COX-1, COX-2, and NF-kB levels and inhibits LPS-induced production of TNF-α, IL-6, and prostaglandin E2 in RAW 264.7 cells. Formulations containing metaxalone have been used in the treatment of lower back pain.
1.Chou, R., Peterson, K., and Helfand, M.Comparative efficacy and safety of skeletal muscle relaxants for spasticity and musculoskeletal conditions: A systematic reviewJ. Pain Symptom Manage.28(2)140-175(2004) 2.Yamaguchi, M., and Levy, R.M.Metaxalone suppresses production of inflammatory cytokines associated with painful conditions in mouse macrophages RAW264.7 cells in vitro: Synergistic effect with β-caryophylleneCurr. Mol. Med.20(8)643-652(2020)
| Cas No. | 1189944-95-3 | SDF | |
| المرادفات | AHR438-d6; NSC170959-d6 | ||
| Canonical SMILES | [2H]C([2H])([2H])C1=CC(C([2H])([2H])[2H])=CC(OCC(O2)CNC2=O)=C1 | ||
| Formula | C12H9D6NO3 | M.Wt | 227.3 |
| الذوبان | Acetonitrile: Soluble | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 4.3995 mL | 21.9974 mL | 43.9947 mL |
| 5 mM | 879.9 μL | 4.3995 mL | 8.7989 mL |
| 10 mM | 439.9 μL | 2.1997 mL | 4.3995 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 7 reference(s) in Google Scholar.)