MPT0B390 |
| رقم الكتالوجGC64729 |
MPT0B390 هو مشتق قائم على أريل سلفوناميد مع قدرة تثبيط قوية لـ HDACMPT0B390 ، محفز TIMP3 ، يمنع نمو الورم ، ورم خبيث وتكوين الأوعيةيُظهر MPT0B390 نشاطًا مضادًا للتكاثر ضد خط خلايا سرطان القولون البشري HCT116 مع GI50 من 0.03 ميكرومتر
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Cas No.: 1817802-18-8
Sample solution is provided at 25 µL, 10mM.
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MPT0B390 is an arylsulfonamide-based derivative with potent HDAC inhibitory ability. MPT0B390, TIMP3 inducer, inhibits tumor growth, metastasis and angiogenesis. MPT0B390 shows antiproliferative activity against human colon cancer cell line HCT116 with the GI50 of 0.03 μM[1].
[1]. Han-Li Huang, et al. TIMP3 expression associates with prognosis in colorectal cancer and its novel arylsulfonamide inducer, MPT0B390, inhibits tumor growth, metastasis and angiogenesis. Theranostics. 2019 Sep 18;9(22):6676-6689.
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