MS402 |
رقم الكتالوجGC64999
One-Click Copy Product Info
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MS402 هو مثبط BET BrD انتقائي BD1 مع Kis من 77 نانومتر ، 718 نانومتر ، 110 نانومتر ، 200 نانومتر ، 83 نانومتر ، و 240 نانومتر لـ BRD4 (BD1) ، BRD4 (BD2) ، BRD3 (BD1) ، BRD3 (BD2) ، BRD2 (BD1) و BRD2 (BD2) ، على التوالي
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1672684-68-2
Sample solution is provided at 25 µL, 10mM.
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MS402 is a BD1-selective BET BrD inhibitor with Kis of 77 nM, 718 nM, 110 nM, 200 nM, 83 nM, and 240 nM for BRD4(BD1), BRD4(BD2), BRD3(BD1), BRD3(BD2), BRD2(BD1) and BRD2(BD2), respectively. MS402 blocks Th17 cell differentiation and ameliorates colitis in mice[1].
Reconstitution with naÏve CD4+CD45RBhi cells isolated from spleen and lymph nodes of C57BL/6 mice, Rag1-/- mice begin losing weight after 4 week. MS402 (10 mg/kg; intraperitoneally twice a week for 3 weeks) shows much less weight loss[1].
[1]. Cheung K, et al. BET N-terminal bromodomain inhibition selectively blocks Th17 cell differentiation and ameliorates colitis in mice. Proc Natl Acad Sci U S A. 2017 Mar 14;114(11):2952-2957.
BRD4-BD1 77nM(Ki) | BRD2-BD1 83nM(Ki) | BRD3-BD1 110nM(Ki) | BRD3-BD2 200nM(Ki) | BRD2-BD2 240nM(Ki) | BRD4-BD2 718nM(Ki) |
| Cas No. | 1672684-68-2 | SDF | |
| Formula | C20H19ClN2O3 | M.Wt | 370.83 |
| الذوبان | DMSO : 100 mg/mL (269.67 mM; Need ultrasonic) | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.6967 mL | 13.4833 mL | 26.9665 mL |
| 5 mM | 539.3 μL | 2.6967 mL | 5.3933 mL |
| 10 mM | 269.7 μL | 1.3483 mL | 2.6967 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)