GLPBio

JNK

JNK (c-Jun N-terminal kinase) is a group of kinases belong to the mitogen-activated protein kinase family and also play a role in T cell differentiation and the cellular apoptosis pathway.

Products Related to JNK(71)

  • GC69322 structure
    GC69322JTP10-Δ -TATi TFA
    Purity: >99.50%

    JTP10-△-TATi TFA هو مثبط ببتيد اختياري لـ JNK2 ، وقيمة IC50 الخاصة به هي 92 نانومتر ، والانتقائية الخاصة به لـ JNK2 أكثر من 10 أضعاف JNK1 و JNK3.

  • GC71114 structure
    GC71114JNK-IN-11
    CAS: 676594-38-0
    Purity: >98.00%

    JNK-IN-11 (المركب 1) هو مثبط قوي لـ JNK مع قيمة IC50 من 2.2 و 21.4 و 1.8 µM ل JNK1 و JNK2 و JNK3 على التوالي.

  • GC71195 structure
    GC71195DN-1289
    CAS: 3026597-15-6

    DN-1289 هو مثبط انتقائي نشط عن طريق الفم لكايناز سحابة الليوسين المزدوج (DLK; IC50=17 نانومتر) وكيناز الليوسين الحامل لزيبر (LZK ؛ IC50=40 نانومتر).

  • GC74163 structure
    GC74163JNK-IN-13
    CAS: 345986-38-1
    Purity: >95.00%

    JNK-IN-13 (المركب 1) هو مثبط قوي وانتقائي مع IC50s من 290 نانومتر و 500 نانومتر ل JNK3 و JNK2، على التوالي.

  • GC74330 structure
    GC74330CMX-8933
    CAS: 146877-90-9
    Purity: >99.00%

    CMX-8933 هو جزء octapeptide من الأسماك الذهبية عامل العصبية الدماغ ependymin.

  • GC79389 structure
    GC79389ETI41
    CAS: 2773474-99-8
    Purity: >98%

    ETI41 is an orally active, selective TLR inhibitor that targets the nucleoside-binding Site I on TLR7 ( IC 50 = 0.63 μM) and TLR9 ( IC 50 = 0.16 μM), sparing surface TLRs (including TLR1/TLR2, TLR2/TLR6, TLR4 and TLR5).

  • GC79390 structure
    GC79390ETI60
    CAS: 2773475-11-7
    Purity: >99.50%

    ETI60 is an orally active, selective TLR inhibitor that targets the nucleoside-binding Site I on TLR7 ( IC 50 = 0.68 μM) and TLR9 ( IC 50 = 0.12 μM), sparing surface TLRs (including TLR1/TLR2, TLR2/TLR6, TLR4 and TLR5).

  • GC79391 structure
    GC79391MyD88-IN-3
    Purity: >99.00%

    MyD88-IN-3 is an orally active, selective MyD88 Inhibitor.

  • GC79475 structure
    GC79475MKK7-JNK activator 1
    CAS: 3100092-62-1
    Purity: >99.50%

    MKK7-JNK activator 1 (Compound 10) is a MKK7-JNK pathway activator.

  • GC81020 structure
    GC81020JNK1 ligand-1-NH-Ph-COOH
    CAS: 3047792-63-9
    Purity: >98.00%

    JNK1 ligand-1 (Compound P1) is a selective JNK1 inhibitor.

  • GC81542 structure
    GC815427-O-Galloyl-D-sedoheptulose
    CAS: 233690-85-2
    Purity: >98%

    7-O-Galloyl-D-sedoheptulose is an orally effective polyphenolic compound.

  • GC81771 structure
    GC81771RANKL-IN-1 formate
    Purity: >99.50%

    RANKL-IN-1 formate is a selective receptor activator of nuclear factor-κB ligand inhibitor ligand ( RANKL ) inhibitor with a K D value of 7.6 μM.

  • GC81827 structure
    GC81827Buforin IIb TFA
    Purity: >98.00%

    Buforin IIb TFA (BF2-B TFA) is an anticancer peptide, as well as an Antibacterial and Antifungal agent.

  • GN10267 structure
    GN10267Loureirin B
    CAS: 119425-90-0
    Purity: >99.00%
  • GN10307 structure
    GN10307Ginsenoside Re
    CAS: 52286-59-6
    Purity: >99.00%

    Ginsenoside Re is a natural compound found in Panax ginseng , possessing potent antioxidant and anti-inflammatory bioactivities.

  • GN10494 structure
    GN10494Astragaloside IV
    CAS: 84687-43-4
    Purity: >98.00%

    Astragaloside IV, an active component isolated from Astragalus membranaceus, can protect the myocardium against ischemia/reperfusion injury and Inhibits HAdV-3 replication and reduces HAdV-3-induced apoptosis.

  • GN10709 structure
    GN10709Polyphyllin A
    CAS: 50773-41-6
    Purity: >98.00%
  • GN10804 structure
    GN10804Isovitexin
    CAS: 38953-85-4 ; 29702-25-8
    Purity: >98.00%

    Isovitexin extracted from rice hulls of Oryza sativa , possesses various biological activities, including anti-inflammatory and antioxidant activities.

  • GC11488 structure
    GC11488TCS JNK 5a
    CAS: 312917-14-9
    Purity: >98.00%

    TCS JNK 5a هو مثبط قوي لـ JNK3 مع pIC50 من 6.7يمنع TCS JNK 5a أيضًا JNK2 مع pIC50 من 6.5

  • GC13529 structure
    GC13529CC-401
    CAS: 395104-30-0
    Purity: >98%

    CC-401 هو مثبط قوي لجميع الأشكال الثلاثة لـ JNK مع Ki من 25 إلى 50 نانومتر

  • GC10204 structure
    GC10204AEG 3482
    CAS: 63735-71-7
    Purity: >99.00%

    AEG 3482 هو مركب قوي مضاد للخلايا يثبط نشاط Jun kinase (JNK) من خلال التعبير المستحث عن بروتين الصدمة الحرارية 70 (HSP70).

  • GC12674 structure
    GC12674IQ 3
    CAS: 312538-03-7
    Purity: >98.50%

    معدل الذكاء 3 هو مثبط محدد لعائلة c-Jun N-terminal kinase (JNK) ، مع تفضيل JNK3.

  • GC12904 structure
    GC12904BI 78D3
    CAS: 883065-90-5
    Purity: >99.00%

    يعمل BI 78D3 كمثبط تنافسي للركيزة لـ JNK ، ويمنع نشاط كيناز JNK (IC50 \u003d 280 نانومتر).