Drug Metabolite
Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.
Products Related to Drug Metabolite(546)
- GC422753-hydroxy DesloratidineCAS: 119410-08-1Purity: >98.00%
3-hydroxy Desloratidine is a major metabolite of desloratadine , a tricyclic antagonist of the histamine H1 receptor.
- GC423073-O-methyl-L-DOPA (hydrate)CAS: 200630-46-2Purity: >98.00%
3-O-methyl-L-DOPA is a metabolite of L-DOPA, produced by the activity of catechol O-methyltransferase.
- GC423704-desmethoxy OmeprazoleCAS: 110374-16-8Purity: >98.00%
4-ديسميثوكسي أوميبرازول هو المستقلب النشط لأوميبرازول
- GC424024-hydroxy (S)-Duloxetine β-D-Glucuronide (sodium salt)Purity: >95.00%
4-hydroxy (S)-Duloxetine β-D-glucuronide is an inactive metabolite of the serotonin and norepinephrine reuptake inhibitor (S)-duloxetine.
- GC424054-hydroxy Atorvastatin (calcium salt)CAS: 265989-44-4Purity: >90.00%
4-hydroxy Atorvastatin is a metabolite of atorvastatin, an HMG-CoA reductase inhibitor present in formulations that have been used to treat hypercholesterolemia and certain dyslipidemias.
- GC424074-hydroxy DiclofenacCAS: 64118-84-9Purity: >97.00%
4-هيدروكسي ديكلوفيناك هو مستقلب نشط عن طريق الفم للديكلوفيناك بواسطة السيتوكروم P450 2C9 (CYP2C9).
- GC424094-hydroxy Nebivolol (hydrochloride)CAS: 2717115-85-8Purity: >98.00%
4-hydroxy Nebivolol is a major metabolite of nebivolol.
- GC424154-hydroxy ValsartanCAS: 188259-69-0Purity: >98.00%
4-hydroxy Valsartan is a major metabolite of the angiotensin II type 1 (AT1) receptor antagonist valsartan.
- GC425465-hydroxy DiclofenacCAS: 69002-84-2Purity: >98.00%
5-hydroxy Diclofenac is a metabolite of the NSAID diclofenac formed by the cytochrome P450 (CYP) isoform CYP3A4.
- GC425485-hydroxy Saxagliptin (hydrochloride)Purity: >95.00%
5-hydroxy Saxagliptin is a major active metabolite of saxagliptin.
- GC425495-hydroxy ThiabendazoleCAS: 948-71-0Purity: >98%
5-hydroxy Thiabendazole (5-OH TBZ) is a major metabolite of the anthelmintic thiabendazole.
- GC425505-hydroxy-6-methoxy (S)-DuloxetineCAS: 741693-79-8Purity: >95.00%
5-hydroxy-6-methoxy (S)-Duloxetine is a metabolite of (S)-duloxetine.
- GC425515-hydroxymethyl Tolterodine (formate)CAS: 380636-49-7Purity: >98.00%
5-hydroxymethyl Tolterodine is an active metabolite of the muscarinic acetylcholine receptor antagonists tolterodine and fesoterodine.
- GC425806-hydroxy ChlorzoxazoneCAS: 1750-45-4Purity: >97.00%
6-hydroxy Chlorzoxazone is the primary metabolite of Chlorzoxazone in vivo. 6-hydroxy Chlorzoxazone is mainly formed through the hepatic cytochrome P450 enzyme system and is commonly used as a probe in biochemical research to quantitatively evaluate CYP2E1 activity.
- GC425846-O-desmethyl DonepezilCAS: 120013-56-1Purity: >98.00%
6-O-desmethyl Donepezil is an active metabolite of the acetylcholinesterase inhibitor donepezil.
- GC425866α-hydroxy PaclitaxelCAS: 153212-75-0Purity: >95.00%
6α ؛ -هيدروكسي باكليتاكسيل هو مستقلب أساسي للباكليتاكسيل. 6α ؛ - يحتفظ هيدروكسي باكليتاكسيل بتأثير يعتمد على الوقت على بولي ببتيدات نقل الأنيون العضوي 1B1 / SLCO1B1 (OATP1B1) مع فعالية تثبيط مماثلة لباكليتاكسيل ، في حين أنه لم يعد يظهر تثبيطًا معتمدًا على الوقت لـ OATP1B3. 6α ؛ -يمكن استخدام هيدروكسي باكليتاكسيل لأبحاث السرطان.
- GC426067-hydroxy Coumarin Glucuronide (sodium salt)CAS: 168286-98-4Purity: >95.00%
7-hydroxy Coumarin Glucuronide (sodium salt) is a phase II metabolite of 7-hydroxycoumarin formed by glucuronidation.
- GC426077-hydroxy Coumarin sulfate (potassium salt)CAS: 1135316-80-1Purity: >98.00%
7-hydroxy Coumarin sulfate is a phase II metabolite of coumarin that can be used as an internal standard for the analysis of 7-hydroxy coumarin metabolism using GC- or LC-MS.
- GC426087-hydroxy Methotrexate (sodium salt)Purity: >96.00%
7-hydroxy Methotrexate (7-hydroxy MTX) is a phase I metabolite of MTX, which is converted by hepatic aldehyde oxidases.
- GC426268-hydroxy EfavirenzCAS: 205754-33-2Purity: >98.00%
8-hydroxy Efavirenz is a major oxidative metabolite of the non-nucleoside reverse transcriptase inhibitor efavirenz.
- GC426339(E)-Erythromycin A oximeCAS: 111321-02-9Purity: >95.00%
(9E)-Erythromycin A oxime is a metabolite of the semisynthetic antibiotic roxithromycin .
- GC42667Abacavir CarboxylateCAS: 384380-52-3Purity: >95.00%
Abacavir carboxylate is an inactive metabolite of the HIV-1 reverse transcriptase inhibitor abacavir.
- GC42690Acecainide (hydrochloride)CAS: 34118-92-8Purity: >98.00%
Acecainide is an active metabolite of the class III antiarrhythmic procainamide.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC42275 | 3-hydroxy Desloratidine | 119410-08-1 | >98.00% | |
3-hydroxy Desloratidine is a major metabolite of desloratadine , a tricyclic antagonist of the histamine H1 receptor. | ||||
| GC42307 | 3-O-methyl-L-DOPA (hydrate) | 200630-46-2 | >98.00% | |
3-O-methyl-L-DOPA is a metabolite of L-DOPA, produced by the activity of catechol O-methyltransferase. | ||||
| GC42370 | 4-desmethoxy Omeprazole | 110374-16-8 | >98.00% | |
4-ديسميثوكسي أوميبرازول هو المستقلب النشط لأوميبرازول | ||||
| GC42401 | 4-hydroperoxy Cyclophosphamide | 39800-16-3 | >95.00% | |
نشط تنشيطًا للسيكلوفوسفاميد. | ||||
| GC42402 | 4-hydroxy (S)-Duloxetine β-D-Glucuronide (sodium salt) | - | >95.00% | |
4-hydroxy (S)-Duloxetine β-D-glucuronide is an inactive metabolite of the serotonin and norepinephrine reuptake inhibitor (S)-duloxetine. | ||||
| GC42405 | 4-hydroxy Atorvastatin (calcium salt) | 265989-44-4 | >90.00% | |
4-hydroxy Atorvastatin is a metabolite of atorvastatin, an HMG-CoA reductase inhibitor present in formulations that have been used to treat hypercholesterolemia and certain dyslipidemias. | ||||
| GC42407 | 4-hydroxy Diclofenac | 64118-84-9 | >97.00% | |
4-هيدروكسي ديكلوفيناك هو مستقلب نشط عن طريق الفم للديكلوفيناك بواسطة السيتوكروم P450 2C9 (CYP2C9). | ||||
| GC42409 | 4-hydroxy Nebivolol (hydrochloride) | 2717115-85-8 | >98.00% | |
4-hydroxy Nebivolol is a major metabolite of nebivolol. | ||||
| GC42415 | 4-hydroxy Valsartan | 188259-69-0 | >98.00% | |
4-hydroxy Valsartan is a major metabolite of the angiotensin II type 1 (AT1) receptor antagonist valsartan. | ||||
| GC42546 | 5-hydroxy Diclofenac | 69002-84-2 | >98.00% | |
5-hydroxy Diclofenac is a metabolite of the NSAID diclofenac formed by the cytochrome P450 (CYP) isoform CYP3A4. | ||||
| GC42548 | 5-hydroxy Saxagliptin (hydrochloride) | - | >95.00% | |
5-hydroxy Saxagliptin is a major active metabolite of saxagliptin. | ||||
| GC42549 | 5-hydroxy Thiabendazole | 948-71-0 | >98% | |
5-hydroxy Thiabendazole (5-OH TBZ) is a major metabolite of the anthelmintic thiabendazole. | ||||
| GC42550 | 5-hydroxy-6-methoxy (S)-Duloxetine | 741693-79-8 | >95.00% | |
5-hydroxy-6-methoxy (S)-Duloxetine is a metabolite of (S)-duloxetine. | ||||
| GC42551 | 5-hydroxymethyl Tolterodine (formate) | 380636-49-7 | >98.00% | |
5-hydroxymethyl Tolterodine is an active metabolite of the muscarinic acetylcholine receptor antagonists tolterodine and fesoterodine. | ||||
| GC42580 | 6-hydroxy Chlorzoxazone | 1750-45-4 | >97.00% | |
6-hydroxy Chlorzoxazone is the primary metabolite of Chlorzoxazone in vivo. 6-hydroxy Chlorzoxazone is mainly formed through the hepatic cytochrome P450 enzyme system and is commonly used as a probe in biochemical research to quantitatively evaluate CYP2E1 activity. | ||||
| GC42584 | 6-O-desmethyl Donepezil | 120013-56-1 | >98.00% | |
6-O-desmethyl Donepezil is an active metabolite of the acetylcholinesterase inhibitor donepezil. | ||||
| GC42586 | 6α-hydroxy Paclitaxel | 153212-75-0 | >95.00% | |
6α ؛ -هيدروكسي باكليتاكسيل هو مستقلب أساسي للباكليتاكسيل. 6α ؛ - يحتفظ هيدروكسي باكليتاكسيل بتأثير يعتمد على الوقت على بولي ببتيدات نقل الأنيون العضوي 1B1 / SLCO1B1 (OATP1B1) مع فعالية تثبيط مماثلة لباكليتاكسيل ، في حين أنه لم يعد يظهر تثبيطًا معتمدًا على الوقت لـ OATP1B3. 6α ؛ -يمكن استخدام هيدروكسي باكليتاكسيل لأبحاث السرطان. | ||||
| GC42606 | 7-hydroxy Coumarin Glucuronide (sodium salt) | 168286-98-4 | >95.00% | |
7-hydroxy Coumarin Glucuronide (sodium salt) is a phase II metabolite of 7-hydroxycoumarin formed by glucuronidation. | ||||
| GC42607 | 7-hydroxy Coumarin sulfate (potassium salt) | 1135316-80-1 | >98.00% | |
7-hydroxy Coumarin sulfate is a phase II metabolite of coumarin that can be used as an internal standard for the analysis of 7-hydroxy coumarin metabolism using GC- or LC-MS. | ||||
| GC42608 | 7-hydroxy Methotrexate (sodium salt) | - | >96.00% | |
7-hydroxy Methotrexate (7-hydroxy MTX) is a phase I metabolite of MTX, which is converted by hepatic aldehyde oxidases. | ||||
| GC42626 | 8-hydroxy Efavirenz | 205754-33-2 | >98.00% | |
8-hydroxy Efavirenz is a major oxidative metabolite of the non-nucleoside reverse transcriptase inhibitor efavirenz. | ||||
| GC42633 | 9(E)-Erythromycin A oxime | 111321-02-9 | >95.00% | |
(9E)-Erythromycin A oxime is a metabolite of the semisynthetic antibiotic roxithromycin . | ||||
| GC42667 | Abacavir Carboxylate | 384380-52-3 | >95.00% | |
Abacavir carboxylate is an inactive metabolite of the HIV-1 reverse transcriptase inhibitor abacavir. | ||||
| GC42690 | Acecainide (hydrochloride) | 34118-92-8 | >98.00% | |
Acecainide is an active metabolite of the class III antiarrhythmic procainamide. | ||||