RR6 |
| رقم الكتالوجGC32740 |
RR6 هو مثبط فعال وانتقائي وقابل للعكس ومنافسة شفويًا لفانين بتركيز IC50 يبلغ 540 نانومتر لفانين-1 المستحث. كما أن RR6 يثبط بشدة البانثوئيناز في المصل الإنسانية والجاموسية والجرذية بأقل من 40 نانومتر ، 41 نانومتر ، 87 نانومتر على التوالي.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1351758-37-6
Sample solution is provided at 25 µL, 10mM.
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RR6 is a selective, reversible, and competitive vanin inhibitor.target: vaninIn vivo: Oral administration of RR6 in rats completely inhibited plasma vanin activity and caused alterations of plasma lipid concentrations upon fasting, thereby illustrating its potential use in chemical biology research. RR6 at 3 mg/mL inrats caused a nearly complete inhibition of plasma vanin.
[1]. Jansen PA et al. Discovery of small molecule vanin inhibitors: new tools to study metabolism and disease. ACS Chem Biol. 2013 Mar 15;8(3):530-4.
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