Secretin is a neuropeptide hormone that regulates secretion from the stomach, pancreas, and liver.1,2 It binds to the rat secretin receptor (SCT-R; Ki = 3.3 nM) and increases intracellular cAMP (EC50 = 1 nM) in COS cells expressing rat SCT-R.3 It also increases SCT-R phosphorylation 7.2-fold at a concentration of 0.1 μM. Secretin dose-dependently increases the volume of pancreatic secretion and inhibits gastric acid secretion induced by gastrin I in rats when administered at a dose of 100 pmol/kg per hour.4
1.Kopin, A.S., Wheeler, M.B., and Leiter, A.B.Secretin: Structure of the precursor and tissue distribution of the mRNAProc. Natl. Acad. Sci. U.S.A.87(6)2299-2303(1990) 2.Sekar, R., and Chow, B.K.Metabolic effects of secretinGen. Comp. Endocrinol.18118-24(2013) 3.Ozcelebi, F., Holtmann, M.H., Rentsch, R.U., et al.Agonist-stimulated phosphorylation of the carboxyl-terminal tail of the secretin receptorMol. Pharmacol.48(5)818-824(1995) 4.Solomon, T.E., Keire, D.A., Gong, P., et al.Receptor subtypes: Species variations in secretin affect potency for pancreatic but not gastric secretionPancreas26(3)300-305(2003)