ASP2453 |
| Catalog No.GC64341 |
ASP2453 is a potent, selective and covalent KRAS G12C inhibitor. ASP2453 inhibits the Son of Sevenless (SOS)-mediated interaction between KRAS G12C and Raf with an IC50 value of 40 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2241719-73-1
Sample solution is provided at 25 µL, 10mM.
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ASP2453 is a potent, selective and covalent KRAS G12C inhibitor. ASP2453 inhibits the Son of Sevenless (SOS)-mediated interaction between KRAS G12C and Raf with an IC50 value of 40 nM.
[1]. Nakayama A, et al. Characterisation of a novel KRAS G12C inhibitor ASP2453 that shows potent anti-tumour activity in KRAS G12C-mutated preclinical models. Br J Cancer. 2021 Nov 18.
Average Rating: 5 (Based on Reviews and 3 reference(s) in Google Scholar.)
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