Aspyrone is a polyketide fungal metabolite that has been found in Aspergillus and has diverse biological activities.1,2 It is active against a panel of 13 fungi when used at a concentration of 20 µg/ml and a panel of 21 bacteria in a disc assay when used at a concentration of 100 µg per disc.1 Aspyrone (10-1,000 mg/L) is nematocidal against P. penetrans.2
1.Torres, M., Balcells, M., Sala, N., et al.Bactericidal and fungicidal activity of Aspergillus ochraceus metabolites and some derivativesPestic. Sci.53(1)9-14(1999) 2.Kimura, Y., Nakahara, S., and Fujioka, S.Aspyrone, a nematicidal compound isolated from the fungus, Aspergillus melleusBiosci. Biotech. Biochem.60(8)1375-1376(1996)