GLPBio

AZD6538

Catalog No.: GC72900
COASDSData Sheet
AZD6538 is a potent, selective and brain penetrant mGluR5 negative allosteric modulator.

Products are for research use only. Not for human use. We do not sell to patients.

AZD6538
Cas No.: 453566-30-8
5 mgIn Stock
$72.00
1
10 mgIn Stock
$117.00
1
25 mgIn Stock
$234.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

Citations

No citations are currently available for this product. Below are selected publications citing GlpBio products.
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    Nature
    641, 529–536 (2025)
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    628, 630–638 (2024)
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    632, 686–694 (2024)
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    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
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    Cell
    183(7):1867-1883 (2020)
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    Science
    388(6745) (2025)
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    35, 97–116 (2025)
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    34, 683–706 (2024)
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    33, 273–287 (2023)
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    33, 546–561 (2023)
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    33, 904–922 (2023)
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    31, 1291–1307 (2021)

Description

AZD6538 is a potent, selective and brain penetrant mGluR5 negative allosteric modulator. AZD6538 inhibits DHPG -stimulated intracellular Ca2+ release in HEK cells expressing rat or human mGluR5, with IC50 values of 3.2 and 13.4 nM for rat mGluR5 and human mGluR5, respectively. AZD6538 can be used for the research of neuropathic pain.

AZD6538 completely reverses the glutamate-stimulated (EC80, 80 μM) phosphatidyl inositol drolysis in human mGluR5-GHEK cells in a concentration-dependent manner, with an IC50 of 51 ± 3 nM[1].

References:
[1]. Raboisson P, et al. Discovery and characterization of AZD9272 and AZD6538-Two novel mGluR5 negative allosteric modulators selected for clinical development. Bioorg Med Chem Lett. 2012 Nov 15;22(22):6974-9.

Product Documents

Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
453566-30-8
Molecular Formula
C15H6FN5O
Molecular Weight
291.24
Solubility
DMSO : 4 mg/mL (13.73 mM; ultrasonic and warming and heat to 60°C)
Storage
4°C, protect from light
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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