GLPBio

BACE

BACE (β-Secretase) is an aspartic-acid protease that cleaves the amyloid precursor protein (APP) and takes part in the generation of Amyloid β.

Products Related to BACE(5)

  • GC17227 structure
    GC17227LY2886721
    CAS: 1262036-50-9
    Purity: >99.50%

    BACE inhibitor

  • GC11098 structure
    GC11098Verubecestat (MK-8931)
    CAS: 1286770-55-5
    Purity: >99.50%

    Verubecestat (MK-8931) (MK-8931) is an orally active, high-affinity BACE1 and BACE2 inhibitor with Ki values of 2.2 nM and 0.38 nM.

  • GC14130 structure
    GC14130AZD3839
    CAS: 1227163-84-9
    Purity: >98.00%

    AZD3839 is a potent and selective orally active, brain-permeable BACE1 inhibitor (Ki=26 nM). AZD3839 shows 14 and >1000-fold selectivity against BACE2 and cathepsin D, respectively. AZD3839 exhibits dose- and time-dependent lowering of plasma, brain, and cerebrospinal fluid Aβ levels in mouse, guinea pig, and non-human primate. AZD3839 can be used for the research of Alzheimer's disease.

  • GC26035 structure
    GC26035Verubecestat (MK-8931) Trifluoroacetate
    CAS: 2095432-65-6
    Purity: >98%

    Verubecestat (MK-8931) Trifluoroacetate is a potent and selective beta-secretase inhibitor and BACE1 protein inhibitor or Beta-site APP-cleaving enzyme 1 inhibitor.

  • GC15715 structure
    GC15715AZD3839
    CAS: 1227163-56-5

    BACE1 inhibitor,potent and selective