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Home >> Signaling Pathways >> Neuroscience

Neuroscience

Neuroscience

Neuroscience

Neurons communicate with each other, effector organs and sensory organs through the neurotransmitter – receptor pathway at synapses. Neurotransmitters can be divided into 4 major groups: 1. Amino acids (glumate, aspartate, serine, glycine and GABA); 2. Monoamines (norepinephrine, epinephrine, dopamine, histamine, and serotonin); 3. Peptides (opioid peptides, substance P, somatostatin); and 4. Others (acetylcholine, NO, nucleosides).

Targets for  Neuroscience

Products for  Neuroscience

  1. Cat.No. Product Name Information
  2. GC63267 α-​Chaconine α-Chaconine inhibits the expressions of COX-2, IL-1β, IL-6, and TNF-α at the transcriptional level. α-​Chaconine Chemical Structure
  3. GC49097 α-Conotoxin AuIB (trifluoroacetate salt) A conotoxin and an antagonist of α3β4 subunit-containing nAChRs α-Conotoxin AuIB (trifluoroacetate salt) Chemical Structure
  4. GC26093 α-Conotoxin GI α-Conotoxin GI, a 13-residue peptide originally isolated from the venom of the fish-hunting cone snail Conus geographus, acts as a competitive antagonist for the muscle-type nicotinic acetylcholine receptor (nAChR) with excellent selectivity for α/δ receptor subunit binding over α/γ. α-Conotoxin GI Chemical Structure
  5. GC49140 α-Conotoxin ImI (trifluoroacetate salt) A conotoxin and an antagonist of α7 nAChRs α-Conotoxin ImI (trifluoroacetate salt) Chemical Structure
  6. GC49838 α-Cortolone A metabolite of cortisol α-Cortolone Chemical Structure
  7. GC40262 α-Humulene α-Humulene is a sesquiterpene that has been found in C. α-Humulene Chemical Structure
  8. GC64563 α-Methylserotonin α-Methylserotonin Chemical Structure
  9. GC48292 α-MSH (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt) α-MSH (α-Melanocyte-Stimulating Hormone) TFA, an endogenous neuropeptide, is an endogenous melanocortin receptor 4 (MC4R) agonist with anti-inflammatory and antipyretic activities. α-MSH (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt) Chemical Structure
  10. GC41499 α-Phellandrene α-Phellandrene is a cyclic monoterpene that has been found in various plants, including Cannabis, and has diverse biological activities. α-Phellandrene Chemical Structure
  11. GC10873 α-Spinasterol TRPV1 antagonist α-Spinasterol Chemical Structure
  12. GC63615 α-Thujone α-Thujone is a monoterpene isolated from Thuja occidentalis essential oil with potent anti-tumor activities. α-Thujone Chemical Structure
  13. GC70179 α7 Nicotinic receptor agonist-1

    Alpha-7 Nicotinic receptor agonist-1 (Preparation 5) is an alpha-7 nAChR agonist. It can be used for research on psychiatric disorders such as schizophrenia, mania or bipolar disorder, and anxiety disorders, as well as intellectual disabilities such as Alzheimer's disease, learning deficits, cognitive impairments, attention deficits, memory loss, Lewy body dementia and attention deficit hyperactivity disorder.

     α7 Nicotinic receptor agonist-1 Chemical Structure
  14. GC49467 β-Aescin A triterpenoid saponin with diverse biological activities β-Aescin Chemical Structure
  15. GC63273 β-Amyloid (1-14),mouse,rat β-Amyloid (1-14),mouse,rat Chemical Structure
  16. GC66089 β-Amyloid (1-40) (TFA) β-Amyloid (1-40) TFA is a primary protein in plaques found in the brains of patients with Alzheimer's disease. β-Amyloid (1-40) (TFA) Chemical Structure
  17. GC70182 β-Amyloid (1-40), FAM-labeled TFA

    Beta-amyloid (1-40), FAM-labeled TFA is a FAM fluorescently labeled beta-amyloid (1-40) peptide (Λex= 492 nm and Λem= 518 nm).

     β-Amyloid (1-40), FAM-labeled TFA Chemical Structure
  18. GC63274 β-Amyloid (1-42), (rat/mouse) (TFA) β-Amyloid (1-42), (rat/mouse) (TFA) Chemical Structure
  19. GC37984 β-Amyloid (1-42), rat β-Amyloid (1-42), rat is a 42-aa peptide, shows cytotoxic effect on acute hippocampal slices, and used in the research of Alzheimer's disease. β-Amyloid (1-42), rat Chemical Structure
  20. GC66416 β-Amyloid (22-35) (TFA) β-Amyloid 22-35 (Amyloid β-Protein 22-35) TFA, the residues 22-35 fragment ofβ-amyloid protein, has a cytotoxic effect on cultured neurons from the rat hippocampus in serum-free medium. β-Amyloid 22-35 TFA forms aggregates and typical amyloid fibrils resembling those of the β-amyloid protein in neutral buffer solution). β-Amyloid (22-35) (TFA) Chemical Structure
  21. GC66346 β-Amyloid (42-1), human TFA β-Amyloid (42-1), human TFA is the inactive form of Amyloid β Peptide (1-42). β-Amyloid (42-1), human TFA is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease. β-Amyloid (42-1), human TFA Chemical Structure
  22. GC37986 β-Amyloid 1-17 β-Amyloid 1-17 is a peptide of β-Amyloid, stabilizes the fibres and plays a role in Aβ fibre formation. β-Amyloid 1-17 Chemical Structure
  23. GC37987 β-Amyloid 1-20 β-Amyloid 1-20 consists of amino acids 1 to 20 of beta amyloid protein. β-Amyloid 1-20 Chemical Structure
  24. GC37993 β-Amyloid 1-9 β-Amyloid 1-9, an N-terminal fragment of beta amyloid, consists of amino acid residues 1 to 9. β-Amyloid 1-9 Chemical Structure
  25. GC37985 β-Amyloid 11-22 β-Amyloid 11-22 is a peptide fragment of β-Amyloid. β-Amyloid 11-22 Chemical Structure
  26. GC37988 β-Amyloid 12-20 β-Amyloid 12-20 is a peptide fragment of β-Amyloid. β-Amyloid 12-20 Chemical Structure
  27. GC37991 β-Amyloid 15-21 β-Amyloid 15-21 Chemical Structure
  28. GC37992 β-Amyloid 18-28 β-Amyloid 18-28 is a peptide fragment of β-Amyloid. β-Amyloid 18-28 Chemical Structure
  29. GC37994 β-Amyloid 22-40 β-Amyloid 22-40 is a peptide fragment of β-Amyloid. β-Amyloid 22-40 Chemical Structure
  30. GC37995 β-Amyloid 33-40 β-Amyloid 33-40 is a peptide consisting of amino acid of 33 to 40 of beta amyloid protein. β-Amyloid 33-40 Chemical Structure
  31. GC37996 β-Amyloid 35-42 β-Amyloid 35-42 is a peptide consisting of amino acid of 35 to 42 of beta amyloid protein. β-Amyloid 35-42 Chemical Structure
  32. GC37997 β-Amyloid 4-10 β-Amyloid 4-10 is an epitope for the polyclonal anti-Aβ(1-42) antibody, reduces amyloid deposition in a transgenic Alzheimer disease mouse model. β-Amyloid 4-10 Chemical Structure
  33. GC34944 β-CGRP, human TFA β-CGRP, human TFA Chemical Structure
  34. GC41623 β-Elemonic Acid β-Elemonic acid is a triterpene isolated from Boswellia (Burseraceae) that exhibits anticancer activity. β-Elemonic Acid Chemical Structure
  35. GC45234 β-Endorphin (1-27) (human) (trifluoroacetate salt) β-Endorphin (1-27) is an endogenous peptide that binds to μ-, δ-, and κ-opioid receptors (Kis = 5.31, 6.17, and 39.82 nM, respectively, in COS-1 cells expressing rat receptors). β-Endorphin (1-27) (human) (trifluoroacetate salt) Chemical Structure
  36. GC45236 β-Endorphin (rat) β-Endorphin (β-EP) is an endogenous opioid neuropeptide with diverse biological activities. β-Endorphin (rat) Chemical Structure
  37. GC52494 β-Endorphin (rat) (trifluoroacetate salt) An opioid neuropeptide β-Endorphin (rat) (trifluoroacetate salt) Chemical Structure
  38. GC49769 β-Glucogallin A plant metabolite and an aldose reductase 2 inhibitor β-Glucogallin Chemical Structure
  39. GC40105 βARK1 Inhibitor βARK1 Inhibitor (methyl 5-[2-(5-nitro-2-furyl)vinyl]-2-furoate) is a GRK2 (β-ARK1) inhibitor. βARK1 Inhibitor Chemical Structure
  40. GC38010 γ-Aminobutyric acid γ-Aminobutyric acid Chemical Structure
  41. GC64508 γ-Aminobutyric acid-d6 γ-Aminobutyric acid-d6 Chemical Structure
  42. GC49865 γ-D-Glutamylglycine (trifluoroacetate salt) An excitatory amino acid antagonist γ-D-Glutamylglycine (trifluoroacetate salt) Chemical Structure
  43. GC48313 γ-Lindane An insecticide and GABAA receptor antagonist γ-Lindane Chemical Structure
  44. GC10872 α-Conotoxin AuIB Selective antagonist of α3β4 nicotinic acetylcholine receptors α-Conotoxin AuIB Chemical Structure
  45. GC13644 α-Conotoxin EI Selective antagonist of neuromuscular nicotinic receptors α1β1γδ α-Conotoxin EI Chemical Structure
  46. GC14353 α-Conotoxin ImI Nicotinic receptor antagonist α-Conotoxin ImI Chemical Structure
  47. GC14296 α-Conotoxin PIA Selective antagonist of α6-containing nicotinic receptors α-Conotoxin PIA Chemical Structure
  48. GC10368 α-Conotoxin PnIA α-Conotoxin PnIA, a potent and selective antagonist of the mammalian α7 nAChR, has the potential for the research of neurological conditions such as neuropathic pain and Alzheimer's disease. α-Conotoxin PnIA Chemical Structure
  49. GC11577 α-Methyl-5-hydroxytryptamine maleate 5-HT2B receptor agonist α-Methyl-5-hydroxytryptamine maleate Chemical Structure
  50. GC34242 β-Amyloid (1-42), rat TFA β-Amyloid (1-42), rat TFA Chemical Structure
  51. GC31146 β-Amyloid (10-35), amide β-Amyloid (10-35), amide is composed of 26 aa (10-35 residues of the Aβ peptide) and is the primary component of the amyloid plaques of Alzheimer's disease. β-Amyloid (10-35), amide Chemical Structure
  52. GC31129 β-Amyloid 1-16 (Amyloid β-Protein (1-16)) β-Amyloid 1-16 (Amyloid β-Protein (1-16)) is a β-Amyloid protein fragment involved in metal binding. β-Amyloid 1-16 (Amyloid β-Protein (1-16)) Chemical Structure
  53. GC31171 β-Amyloid 1-28 (Amyloid β-Protein (1-28)) β-Amyloid 1-28 (Amyloid β-Protein (1-28)) is a β-Amyloid protein fragment involved in metal binding. β-Amyloid 1-28 (Amyloid β-Protein (1-28)) Chemical Structure
  54. GC30325 β-Amyloid 22-35 (Amyloid β-Protein (22-35)) β-Amyloid 22-35 (Amyloid β-Protein 22-35), the residues 22-35 fragment ofβ-amyloid protein, has a cytotoxic effect on cultured neurons from the rat hippocampus in serum-free medium. β-Amyloid 22-35 (Amyloid β-Protein (22-35)) Chemical Structure
  55. GC31137 β-Amyloid 29-40 (Amyloid beta-protein(29-40)) β-Amyloid 29-40 (Amyloid beta-protein(29-40)) is a fragment of Amyloid-β peptide. β-Amyloid 29-40 (Amyloid beta-protein(29-40)) Chemical Structure
  56. GC31179 β-Amyloid 31-35 β-Amyloid 31-35 is the shortest sequence of native Amyloid-β peptide that retains neurotoxic activity. β-Amyloid 31-35 Chemical Structure
  57. GC11449 β-CCB

    benzodiazepine receptor ligand

     β-CCB Chemical Structure
  58. GC33595 β-CGRP, human (Human β-CGRP) β-CGRP, human (Human β-CGRP) (Human β-CGRP) is one of calcitonin peptides, acts via the complex of calcitonin-receptor-like receptor (CRLR) and receptor-activity-modifying protein (RAMP), with IC50s of 1 nM and 300 nM for CRLR/RAMP1 and CRLR/RAMP2 in cells. β-CGRP, human (Human β-CGRP) Chemical Structure
  59. GC18033 γDGG γDGG is a competitive AMPA receptor blocker. γDGG Chemical Structure
  60. GC52013 (±)-10-hydroxy-12(Z)-Octadecenoic Acid An oxylipin and metabolite of linoleic acid (±)-10-hydroxy-12(Z)-Octadecenoic Acid Chemical Structure
  61. GC52421 (±)-10-hydroxy-12(Z)-Octadecenoic Acid-d5 An internal standard for the quantification of (±)-10-hydroxy-12(Z)-octadecenoic acid (±)-10-hydroxy-12(Z)-Octadecenoic Acid-d5 Chemical Structure
  62. GC41657 (±)-2-Amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene (hydrobromide) (±)-2-Amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene (6,7-ADTN) is a dopamine receptor agonist (EC50s = 3.5 and 0.65 μM in rat striatal and nucleus accumbens homogenates, respectively). (±)-2-Amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene (hydrobromide) Chemical Structure
  63. GC41658 (±)-2-hydroxy Ibuprofen (±)-2-hydroxy Ibuprofen is a metabolite of ibuprofen . (±)-2-hydroxy Ibuprofen Chemical Structure
  64. GC62726 (±)-Amiflamine (±)-Amiflamine (FLA 336) is a potent monoamine oxidase-A (MAO-A) inhibitor with a pIC50 of 5.57. (±)-Amiflamine Chemical Structure
  65. GC46272 (±)-Asenapine-13C-d3 (hydrochloride) An internal standard for the quantification of (±)-asenapine (±)-Asenapine-13C-d3 (hydrochloride) Chemical Structure
  66. GC46274 (±)-Baclofen-d4 An internal standard for the quantification of (±)-baclofen (±)-Baclofen-d4 Chemical Structure
  67. GC60394 (±)-Duloxetine hydrochloride (±)-Duloxetine ((Rac)-Duloxetine) hydrochloride is the racemate of Duloxetine hydrochloride. (±)-Duloxetine hydrochloride Chemical Structure
  68. GC14410 (±)-Epibatidine nicotinic agonist (±)-Epibatidine Chemical Structure
  69. GC46288 (±)-Epibatidine (hydrochloride) An agonist of α4β2 subunit-containing nAChRs (±)-Epibatidine (hydrochloride) Chemical Structure
  70. GC46290 (±)-Ibuprofen-d3 An Analytical Reference Standard (±)-Ibuprofen-d3 Chemical Structure
  71. GC49515 (±)-Ibuprofen-d3 (sodium salt) An internal standard for the quantification of (±)-ibuprofen (±)-Ibuprofen-d3 (sodium salt) Chemical Structure
  72. GC45278 (±)-Ketoprofen-d3   (±)-Ketoprofen-d3 Chemical Structure
  73. GC12699 (±)-LY 395756 ligand for mGlu2 and mGlu3 receptor (±)-LY 395756 Chemical Structure
  74. GC16735 (±)-McN 5652 5-HT uptake inhibitor (±)-McN 5652 Chemical Structure
  75. GC49875 (±)-N-desmethyl Venlafaxine (hydrochloride) A minor active metabolite of venlafaxine (±)-N-desmethyl Venlafaxine (hydrochloride) Chemical Structure
  76. GC46305 (±)-Nicotine-d3 An internal standard for the quantification of (±)-nicotine (±)-Nicotine-d3 Chemical Structure
  77. GC14834 (±)-Nipecotic acid GABA uptake inhibitor (±)-Nipecotic acid Chemical Structure
  78. GC41676 (±)-Nornicotine (±)-Nornicotine is a metabolite of nicotine that acts as a neuronal nicotinic acetylcholine receptor (nAChR) agonist. (±)-Nornicotine Chemical Structure
  79. GC49482 (±)-Nornicotine-d4 An internal standard for the quantification of (±)-nornicotine (±)-Nornicotine-d4 Chemical Structure
  80. GC12394 (±)-trans-ACPD

    metabotropic glutamate receptors agonist

     (±)-trans-ACPD Chemical Structure
  81. GC11128 (±)-Vesamicol hydrochloride acetylcholine transport inhibitor (±)-Vesamicol hydrochloride Chemical Structure
  82. GC41685 (±)-WIN 55,212 (mesylate) (±)-WIN 55,212-2 is a potent aminoalkylindole cannabinoid (CB) receptor agonist with a Ki value of 62.3 and 3.3 nM for human recombinant central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors, respectively. (±)-WIN 55,212 (mesylate) Chemical Structure
  83. GC41213 (±)10-HDHA

    (±)10-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro.

     (±)10-HDHA Chemical Structure
  84. GC41214 (±)11-HDHA (±)11-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. (±)11-HDHA Chemical Structure
  85. GC40467 (±)11-HETE (±)11-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid. (±)11-HETE Chemical Structure
  86. GC40802 (±)12(13)-DiHOME

    (±)12(13)-DiHOME is the diol form of (±)12(13)-EpOME, a cytochrome P450-derived epoxide of linoleic acid also known as isoleukotoxin.

     (±)12(13)-DiHOME Chemical Structure
  87. GC41191 (±)13(14)-EpDPA Cytochrome P450 metabolism of polyunsaturated fatty acids produces numerous bioactive epoxide regioisomers. (±)13(14)-EpDPA Chemical Structure
  88. GC41192 (±)13-HDHA (±)13-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. (±)13-HDHA Chemical Structure
  89. GC41193 (±)14-HDHA (±)14-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. (±)14-HDHA Chemical Structure
  90. GC41194 (±)16(17)-EpDPA

    EDHF (endothelium-derived hyperpolarizing factor) is an unidentified mediator released from vascular endothelial cells in response to acetylcholine and bradykinin which is distinct from the NOS- (nitric oxide) and COX-derived (prostacyclin) vasodilators.

     (±)16(17)-EpDPA Chemical Structure
  91. GC41196 (±)16-HDHA (±)16-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. (±)16-HDHA Chemical Structure
  92. GC41197 (±)17-HDHA (±)17-HDHA is an autoxidation product of docosahexaenoic acid in vitro. (±)17-HDHA Chemical Structure
  93. GC41199 (±)19(20)-EpDPA EDHF (endothelium-derived hyperpolarizing factor) is an unidentified mediator released from vascular endothelial cells in response to acetylcholine and bradykinin which is distinct from the NOS- (nitric oxide) and COX-derived (prostacyclin) vasodilators. (±)19(20)-EpDPA Chemical Structure
  94. GC41202 (±)4-HDHA (±)4-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. (±)4-HDHA Chemical Structure
  95. GC41203 (±)7(8)-EpDPA Docosahexaenoic acid is the most abundant ω-3 fatty acid in neural tissues, especially in the brain and retina. (±)7(8)-EpDPA Chemical Structure
  96. GC41204 (±)7-HDHA

    (±)7-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro.

     (±)7-HDHA Chemical Structure
  97. GC41205 (±)8-HDHA (±)8-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. (±)8-HDHA Chemical Structure
  98. GC33544 (±)-Methotrimeprazine (D6) (dl-Methotrimeprazine D6) (±)-Levomepromazine D6 ((±)-Methotrimeprazine D6) is the deuterium labeled Methotrimeprazine, which is a D3 dopamine and Histamine H1 receptor antagonist. (±)-Methotrimeprazine (D6) (dl-Methotrimeprazine D6) Chemical Structure
  99. GC31026 (±)-Tazifylline (±)-Tazifylline is a potent, selective and long-acting histamine H1 receptor antagonist. (±)-Tazifylline Chemical Structure
  100. GN10155 (+)- Corydaline (+)- Corydaline Chemical Structure
  101. GC13156 (+)-AJ 76 hydrochloride Dopamine receptor antagonist (+)-AJ 76 hydrochloride Chemical Structure

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