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Home >> Signaling Pathways >> Neuroscience

Neuroscience

Neuroscience

Neuroscience

Neurons communicate with each other, effector organs and sensory organs through the neurotransmitter – receptor pathway at synapses. Neurotransmitters can be divided into 4 major groups: 1. Amino acids (glumate, aspartate, serine, glycine and GABA); 2. Monoamines (norepinephrine, epinephrine, dopamine, histamine, and serotonin); 3. Peptides (opioid peptides, substance P, somatostatin); and 4. Others (acetylcholine, NO, nucleosides).

Targets for  Neuroscience

Products for  Neuroscience

  1. Cat.No. Product Name Information
  2. GC19941 DL-Leucic Acid DL-Leucic Acid Chemical Structure
  3. GC20029 L(-)-Borneol L(-)-Borneol Chemical Structure
  4. GC63267 α-​Chaconine α-Chaconine inhibits the expressions of COX-2, IL-1β, IL-6, and TNF-α at the transcriptional level. α-​Chaconine Chemical Structure
  5. GC45196 α-Bungarotoxin (trifluoroacetate salt)

    α-Bungarotoxin is a snake venom-derived toxin that irreversibly binds nicotinic acetylcholine receptors (Ki = ~2.5 μM in rat) present in skeletal muscle, blocking action of acetylcholine at the postsynaptic membrane and leading to paralysis.

     α-Bungarotoxin (trifluoroacetate salt) Chemical Structure
  6. GC74347 α-Casozepine α-Casozepine is a bioactive peptide derived from the α protein S1 casein in milk and has an affinity for γ-aminobutyric acid (GABA) receptors in the brain. α-Casozepine Chemical Structure
  7. GC45198 α-CGRP (8-37) (human) (trifluoroacetate salt)

    Calcitonin Gene-Related Peptide-1 (8-37) (human), CGRP-1 (8-37) (human), α-Calcitonin Gene-Related Peptide (8-37) (human)

     Calcitonin gene-related protein (CGRP) is a neuropeptide and a product of alternative splicing of the calcitonin gene. α-CGRP (8-37) (human) (trifluoroacetate salt) Chemical Structure
  8. GC72093 α-CGRP (mouse, rat) (TFA) α-CGRP (mouse, rat) TFA, a neuropeptide (calcitonin gene-related peptide (CGRP)) mainly expressed in neuromuscular junction, is a potent vasodilator. α-CGRP (mouse, rat) (TFA) Chemical Structure
  9. GC72110 α-CGRP(human) TFA α-CGRP(human) TFA is a regulatory neuropeptide of 37 amino acids. α-CGRP(human) TFA Chemical Structure
  10. GC49097 α-Conotoxin AuIB (trifluoroacetate salt)

    GCCSYPPCFATNPDC

     A conotoxin and an antagonist of α3β4 subunit-containing nAChRs α-Conotoxin AuIB (trifluoroacetate salt) Chemical Structure
  11. GC26093 α-Conotoxin GI

    α-Conotoxin GI, a 13-residue peptide originally isolated from the venom of the fish-hunting cone snail Conus geographus, acts as a competitive antagonist for the muscle-type nicotinic acetylcholine receptor (nAChR) with excellent selectivity for α/δ receptor subunit binding over α/γ.

     α-Conotoxin GI Chemical Structure
  12. GC49140 α-Conotoxin ImI (trifluoroacetate salt)

    α-CTx ImI, GCCSDPRCAWRC

     A conotoxin and an antagonist of α7 nAChRs α-Conotoxin ImI (trifluoroacetate salt) Chemical Structure
  13. GC49838 α-Cortolone

    20α-Cortolone, NSC 59872

     A metabolite of cortisol α-Cortolone Chemical Structure
  14. GC40262 α-Humulene

    αCaryophyllene, (±)-αHumulene

     α-Humulene is a sesquiterpene that has been found in C. α-Humulene Chemical Structure
  15. GC64563 α-Methylserotonin α-Methylserotonin Chemical Structure
  16. GC48292 α-MSH (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt)

    α-Melanocyte-stimulating Hormone, Ac-SYSMEHFRWGKPV-NH2

     α-MSH (α-Melanocyte-Stimulating Hormone) TFA, an endogenous neuropeptide, is an endogenous melanocortin receptor 4 (MC4R) agonist with anti-inflammatory and antipyretic activities. α-MSH (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt) Chemical Structure
  17. GC41499 α-Phellandrene

    p-Mentha-1,5-diene, (±)-α-Phellandrene

     α-Phellandrene is a cyclic monoterpene that has been found in various plants, including Cannabis, and has diverse biological activities. α-Phellandrene Chemical Structure
  18. GC10873 α-Spinasterol

    Bessisterol, Hitodesterol

     TRPV1 antagonist α-Spinasterol Chemical Structure
  19. GC63615 α-Thujone α-Thujone is a monoterpene isolated from Thuja occidentalis essential oil with potent anti-tumor activities. α-Thujone Chemical Structure
  20. GC70179 α7 Nicotinic receptor agonist-1

    Alpha-7 Nicotinic receptor agonist-1 (Preparation 5) is an alpha-7 nAChR agonist. It can be used for research on psychiatric disorders such as schizophrenia, mania or bipolar disorder, and anxiety disorders, as well as intellectual disabilities such as Alzheimer's disease, learning deficits, cognitive impairments, attention deficits, memory loss, Lewy body dementia and attention deficit hyperactivity disorder.

     α7 Nicotinic receptor agonist-1 Chemical Structure
  21. GC72246 αC-Conotoxin PrXA αC-Conotoxin PrXA is a paralytic peptide neurotoxin and a competitive nAChR antagonist, with IC50s of 1.8 nM (α1β1εδ, adult) and 3.0 nM (α1β1γδ, fetal), respectively. αC-Conotoxin PrXA Chemical Structure
  22. GC49467 β-Aescin A triterpenoid saponin with diverse biological activities β-Aescin Chemical Structure
  23. GC63273 β-Amyloid (1-14),mouse,rat β-Amyloid (1-14),mouse,rat Chemical Structure
  24. GC66089 β-Amyloid (1-40) (TFA)

    Amyloid Beta-Peptide (1-40) (human) TFA; Amyloid β-Peptide (1-40) (human) TFA

     β-Amyloid (1-40) TFA is a primary protein in plaques found in the brains of patients with Alzheimer's disease. β-Amyloid (1-40) (TFA) Chemical Structure
  25. GC70182 β-Amyloid (1-40), FAM-labeled TFA

    Beta-amyloid (1-40), FAM-labeled TFA is a FAM fluorescently labeled beta-amyloid (1-40) peptide (Λex= 492 nm and Λem= 518 nm).

     β-Amyloid (1-40), FAM-labeled TFA Chemical Structure
  26. GC63274 β-Amyloid (1-42), (rat/mouse) (TFA)

    Amyloid β-peptide (1-42) (rat/mouse) TFA

     β-Amyloid (1-42), (rat/mouse) (TFA) Chemical Structure
  27. GC37984 β-Amyloid (1-42), rat

    Amyloid β-peptide (1-42) (rat/mouse)

     β-Amyloid (1-42), rat is a 42-aa peptide, shows cytotoxic effect on acute hippocampal slices, and used in the research of Alzheimer's disease. β-Amyloid (1-42), rat Chemical Structure
  28. GC66416 β-Amyloid (22-35) (TFA)

    Amyloid β-Protein (22-35) (TFA)

     β-Amyloid 22-35 (Amyloid β-Protein 22-35) TFA, the residues 22-35 fragment ofβ-amyloid protein, has a cytotoxic effect on cultured neurons from the rat hippocampus in serum-free medium. β-Amyloid 22-35 TFA forms aggregates and typical amyloid fibrils resembling those of the β-amyloid protein in neutral buffer solution). β-Amyloid (22-35) (TFA) Chemical Structure
  29. GC66346 β-Amyloid (42-1), human TFA

    Amyloid β Peptide (42-1)(human) TFA

     β-Amyloid (42-1), human TFA is the inactive form of Amyloid β Peptide (1-42). β-Amyloid (42-1), human TFA is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease. β-Amyloid (42-1), human TFA Chemical Structure
  30. GC37986 β-Amyloid 1-17 β-Amyloid 1-17 is a peptide of β-Amyloid, stabilizes the fibres and plays a role in Aβ fibre formation. β-Amyloid 1-17 Chemical Structure
  31. GC37987 β-Amyloid 1-20 β-Amyloid 1-20 consists of amino acids 1 to 20 of beta amyloid protein. β-Amyloid 1-20 Chemical Structure
  32. GC37993 β-Amyloid 1-9 β-Amyloid 1-9, an N-terminal fragment of beta amyloid, consists of amino acid residues 1 to 9. β-Amyloid 1-9 Chemical Structure
  33. GC37985 β-Amyloid 11-22 β-Amyloid 11-22 is a peptide fragment of β-Amyloid. β-Amyloid 11-22 Chemical Structure
  34. GC37988 β-Amyloid 12-20 β-Amyloid 12-20 is a peptide fragment of β-Amyloid. β-Amyloid 12-20 Chemical Structure
  35. GC37991 β-Amyloid 15-21 β-Amyloid 15-21 Chemical Structure
  36. GC37992 β-Amyloid 18-28 β-Amyloid 18-28 is a peptide fragment of β-Amyloid. β-Amyloid 18-28 Chemical Structure
  37. GC37994 β-Amyloid 22-40 β-Amyloid 22-40 is a peptide fragment of β-Amyloid. β-Amyloid 22-40 Chemical Structure
  38. GC37995 β-Amyloid 33-40 β-Amyloid 33-40 is a peptide consisting of amino acid of 33 to 40 of beta amyloid protein. β-Amyloid 33-40 Chemical Structure
  39. GC37996 β-Amyloid 35-42 β-Amyloid 35-42 is a peptide consisting of amino acid of 35 to 42 of beta amyloid protein. β-Amyloid 35-42 Chemical Structure
  40. GC37997 β-Amyloid 4-10 β-Amyloid 4-10 is an epitope for the polyclonal anti-Aβ(1-42) antibody, reduces amyloid deposition in a transgenic Alzheimer disease mouse model. β-Amyloid 4-10 Chemical Structure
  41. GC74300 β-CGRP (mouse)

    Calcitonin gene-related peptide 2 (mouse); CGRP II (mouse

     β-CGRP (mouse) is a calcitonin gene-related peptide that induces vasodilation. β-CGRP (mouse) Chemical Structure
  42. GC34944 β-CGRP, human TFA

    Human β-CGRP TFA; CGRP-II (Human) (TFA)

     β-CGRP, human TFA Chemical Structure
  43. GC41623 β-Elemonic Acid

    Elemadienonic Acid, 3-Oxotirucallenoic Acid, 3-oxo Tirucallic Acid

     β-Elemonic acid is a triterpene isolated from Boswellia (Burseraceae) that exhibits anticancer activity. β-Elemonic Acid Chemical Structure
  44. GC45233 β-Endorphin (1-26) (human) (trifluoroacetate salt) β-endorphin (1-26) is a neuropeptide found in rat hippocampus, brain stem, and pituitary. β-Endorphin (1-26) (human) (trifluoroacetate salt) Chemical Structure
  45. GC45234 β-Endorphin (1-27) (human) (trifluoroacetate salt) β-Endorphin (1-27) is an endogenous peptide that binds to μ-, δ-, and κ-opioid receptors (Kis = 5.31, 6.17, and 39.82 nM, respectively, in COS-1 cells expressing rat receptors). β-Endorphin (1-27) (human) (trifluoroacetate salt) Chemical Structure
  46. GC48300 β-Endorphin (human) (trifluoroacetate salt)

    β-Lipotropin (61-91)

     A neuropeptide with diverse biological activities β-Endorphin (human) (trifluoroacetate salt) Chemical Structure
  47. GC45236 β-Endorphin (rat) β-Endorphin (β-EP) is an endogenous opioid neuropeptide with diverse biological activities. β-Endorphin (rat) Chemical Structure
  48. GC52494 β-Endorphin (rat) (trifluoroacetate salt) An opioid neuropeptide β-Endorphin (rat) (trifluoroacetate salt) Chemical Structure
  49. GC49769 β-Glucogallin

    1-O-Galloyl-β-D-glucose

     A plant metabolite and an aldose reductase 2 inhibitor β-Glucogallin Chemical Structure
  50. GC40105 βARK1 Inhibitor βARK1 Inhibitor (methyl 5-[2-(5-nitro-2-furyl)vinyl]-2-furoate) is a GRK2 (β-ARK1) inhibitor. βARK1 Inhibitor Chemical Structure
  51. GC70650 γ-Acetylenic GABA hydrochloride γ-Acetylenic GABA (GAG) hydrochloride is an irreversible inhibitor of GABA-transaminase. γ-Acetylenic GABA hydrochloride Chemical Structure
  52. GC38010 γ-Aminobutyric acid γ-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the adult brain. γ-Aminobutyric acid Chemical Structure
  53. GC64508 γ-Aminobutyric acid-d6

    γ-Aminobutyric acid-d6 (4-Aminobutyric acid-d6) is the deuterium labeled γ-Aminobutyric acid.

     γ-Aminobutyric acid-d6 Chemical Structure
  54. GC49865 γ-D-Glutamylglycine (trifluoroacetate salt)

    γ-DGG

     An excitatory amino acid antagonist γ-D-Glutamylglycine (trifluoroacetate salt) Chemical Structure
  55. GC48313 γ-Lindane An insecticide and GABAA receptor antagonist γ-Lindane Chemical Structure
  56. GC92102 γ1-MSH (human, mouse, rat, bovine) (acetate)

    γ1-Melanocyte-stimulating Hormone

     γ1-Melanocyte-stimulating hormone (γ1-MSH) is a peptide hormone produced by post-translational processing of proopiomelanocortin (POMC) in the pituitary gland. γ1-MSH (human, mouse, rat, bovine) (acetate) Chemical Structure
  57. GC92101 γ1-MSH (human, mouse, rat, bovine) (trifluoroacetate salt)

    γ1-Melanocyte-stimulating Hormone

     γ1-Melanocyte-stimulating hormone (γ1-MSH) is a peptide hormone produced by post-translational processing of proopiomelanocortin (POMC) in the pituitary gland. γ1-MSH (human, mouse, rat, bovine) (trifluoroacetate salt) Chemical Structure
  58. GC10872 α-Conotoxin AuIB Selective antagonist of α3β4 nicotinic acetylcholine receptors α-Conotoxin AuIB Chemical Structure
  59. GC13644 α-Conotoxin EI Selective antagonist of neuromuscular nicotinic receptors α1β1γδ α-Conotoxin EI Chemical Structure
  60. GC14353 α-Conotoxin ImI Nicotinic receptor antagonist α-Conotoxin ImI Chemical Structure
  61. GC14296 α-Conotoxin PIA Selective antagonist of α6-containing nicotinic receptors α-Conotoxin PIA Chemical Structure
  62. GC10368 α-Conotoxin PnIA α-Conotoxin PnIA, a potent and selective antagonist of the mammalian α7 nAChR, has the potential for the research of neurological conditions such as neuropathic pain and Alzheimer's disease. α-Conotoxin PnIA Chemical Structure
  63. GC11577 α-Methyl-5-hydroxytryptamine maleate

    α-Me-5-HT, α-Methyl-5-HT, α-Methyl-5-hydroxytryptamine, α-Methylserotonin

     5-HT2B receptor agonist α-Methyl-5-hydroxytryptamine maleate Chemical Structure
  64. GC34242 β-Amyloid (1-42), rat TFA β-Amyloid (1-42), rat TFA Chemical Structure
  65. GC31146 β-Amyloid (10-35), amide β-Amyloid (10-35), amide is composed of 26 aa (10-35 residues of the Aβ peptide) and is the primary component of the amyloid plaques of Alzheimer's disease. β-Amyloid (10-35), amide Chemical Structure
  66. GC31129 β-Amyloid 1-16 (Amyloid β-Protein (1-16))

    Amyloid β-Protein (1-16)

     β-Amyloid 1-16 (Amyloid β-Protein (1-16)) is a β-Amyloid protein fragment involved in metal binding. β-Amyloid 1-16 (Amyloid β-Protein (1-16)) Chemical Structure
  67. GC31171 β-Amyloid 1-28 (Amyloid β-Protein (1-28))

    Amyloid β-Protein (1-28)

     β-Amyloid 1-28 (Amyloid β-Protein (1-28)) is a β-Amyloid protein fragment involved in metal binding. β-Amyloid 1-28 (Amyloid β-Protein (1-28)) Chemical Structure
  68. GC30325 β-Amyloid 22-35 (Amyloid β-Protein (22-35)) β-Amyloid 22-35 (Amyloid β-Protein 22-35), the residues 22-35 fragment ofβ-amyloid protein, has a cytotoxic effect on cultured neurons from the rat hippocampus in serum-free medium. β-Amyloid 22-35 (Amyloid β-Protein (22-35)) Chemical Structure
  69. GC31137 β-Amyloid 29-40 (Amyloid beta-protein(29-40)) β-Amyloid 29-40 (Amyloid beta-protein(29-40)) is a fragment of Amyloid-β peptide. β-Amyloid 29-40 (Amyloid beta-protein(29-40)) Chemical Structure
  70. GC31179 β-Amyloid 31-35 β-Amyloid 31-35 is the shortest sequence of native Amyloid-β peptide that retains neurotoxic activity. β-Amyloid 31-35 Chemical Structure
  71. GC11449 β-CCB

    benzodiazepine receptor ligand

     β-CCB Chemical Structure
  72. GC33595 β-CGRP, human (Human β-CGRP) β-CGRP, human (Human β-CGRP) (Human β-CGRP) is one of calcitonin peptides, acts via the complex of calcitonin-receptor-like receptor (CRLR) and receptor-activity-modifying protein (RAMP), with IC50s of 1 nM and 300 nM for CRLR/RAMP1 and CRLR/RAMP2 in cells. β-CGRP, human (Human β-CGRP) Chemical Structure
  73. GC18033 γDGG γDGG is a competitive AMPA receptor blocker. γDGG Chemical Structure
  74. GC45240 ω-Agatoxin IVA (trifluoroacetate salt)

    ω-Aga IVa, SNX-290

     ω-Agatoxin IVA is a natural peptide first isolated from the venom of funnel spiders. ω-Agatoxin IVA (trifluoroacetate salt) Chemical Structure
  75. GC45241 ω-Conotoxin GVIA (trifluoroacetate salt) ω-Conotoxin GVIA is a peptide originally isolated from the marine mollusk C. ω-Conotoxin GVIA (trifluoroacetate salt) Chemical Structure
  76. GC45242 ω-Conotoxin MVIIC (trifluoroacetate salt)

    SNX-230

     ω-Conotoxin MVIIC is a peptide originally isolated from the marine mollusk C. ω-Conotoxin MVIIC (trifluoroacetate salt) Chemical Structure
  77. GC52013 (±)-10-hydroxy-12(Z)-Octadecenoic Acid

    10-hydroxy-cis-12-Octadecenoic Acid

     An oxylipin and metabolite of linoleic acid (±)-10-hydroxy-12(Z)-Octadecenoic Acid Chemical Structure
  78. GC52421 (±)-10-hydroxy-12(Z)-Octadecenoic Acid-d5

    10-hydroxy-cis-12-Octadecenoic Acid-d5

     An internal standard for the quantification of (±)-10-hydroxy-12(Z)-octadecenoic acid (±)-10-hydroxy-12(Z)-Octadecenoic Acid-d5 Chemical Structure
  79. GC41657 (±)-2-Amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene (hydrobromide)

    (±)-ADTN, 6,7-ADTN, 6,7-diOHATN, NSC 287353

     (±)-2-Amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene (6,7-ADTN) is a dopamine receptor agonist (EC50s = 3.5 and 0.65 μM in rat striatal and nucleus accumbens homogenates, respectively). (±)-2-Amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene (hydrobromide) Chemical Structure
  80. GC41658 (±)-2-hydroxy Ibuprofen (±)-2-hydroxy Ibuprofen is a metabolite of ibuprofen . (±)-2-hydroxy Ibuprofen Chemical Structure
  81. GC62726 (±)-Amiflamine (±)-Amiflamine (FLA 336) is a potent monoamine oxidase-A (MAO-A) inhibitor with a pIC50 of 5.57. (±)-Amiflamine Chemical Structure
  82. GC46272 (±)-Asenapine-13C-d3 (hydrochloride) An internal standard for the quantification of (±)-asenapine (±)-Asenapine-13C-d3 (hydrochloride) Chemical Structure
  83. GC46274 (±)-Baclofen-d4 An internal standard for the quantification of (±)-baclofen (±)-Baclofen-d4 Chemical Structure
  84. GC72625 (±)-Coniine hydrochloride (±)-Coniine hydrochloride (2-Propylpiperidine hydrochloride) is a potent nAChR agonist with an EC50 value of 0.3 mM. (±)-Coniine hydrochloride Chemical Structure
  85. GC60394 (±)-Duloxetine hydrochloride

    (Rac)-Duloxetine hydrochloride

     (±)-Duloxetine ((Rac)-Duloxetine) hydrochloride is the racemate of Duloxetine hydrochloride. (±)-Duloxetine hydrochloride Chemical Structure
  86. GC14410 (±)-Epibatidine

    CMI 545

     nicotinic agonist (±)-Epibatidine Chemical Structure
  87. GC46288 (±)-Epibatidine (hydrochloride)

    CMI 545 dihydrochloride

     An agonist of α4β2 subunit-containing nAChRs (±)-Epibatidine (hydrochloride) Chemical Structure
  88. GC46290 (±)-Ibuprofen-d3

    DL-Ibuprofen-d3

     An Analytical Reference Standard (±)-Ibuprofen-d3 Chemical Structure
  89. GC49515 (±)-Ibuprofen-d3 (sodium salt)

    DL-Ibuprofen-d3

     An internal standard for the quantification of (±)-ibuprofen (±)-Ibuprofen-d3 (sodium salt) Chemical Structure
  90. GC45278 (±)-Ketoprofen-d3

    (R,S)-Ketoprofen-d3, 2-(3-benzoylphenyl)Propionic Acid-d3

       (±)-Ketoprofen-d3 Chemical Structure
  91. GC91298 (±)-Linalool-d3

    An internal standard for the quantification of (±)-linalool

     (±)-Linalool-d3 Chemical Structure
  92. GC12699 (±)-LY 395756 ligand for mGlu2 and mGlu3 receptor (±)-LY 395756 Chemical Structure
  93. GC16735 (±)-McN 5652

    5-HT uptake inhibitor

     (±)-McN 5652 Chemical Structure
  94. GC49875 (±)-N-desmethyl Venlafaxine (hydrochloride)

    Wy 45494

     A minor active metabolite of venlafaxine (±)-N-desmethyl Venlafaxine (hydrochloride) Chemical Structure
  95. GC46305 (±)-Nicotine-d3

    DL-Nicotine-d3, (±)-Nicotine-methyl-d3

     An internal standard for the quantification of (±)-nicotine (±)-Nicotine-d3 Chemical Structure
  96. GC14834 (±)-Nipecotic acid

    (±)-Nipecotic Acid, (R,S)-Nipecotic Acid, 3-Piperidine Carboxylic Acid, DL-Piperidine 3-Carboxylic Acid

     GABA uptake inhibitor (±)-Nipecotic acid Chemical Structure
  97. GC90022 (±)-Norepinephrine-d6 (hydrochloride)

    An internal standard for the quantification of norepinephrine

     (±)-Norepinephrine-d6 (hydrochloride) Chemical Structure
  98. GC41676 (±)-Nornicotine

    DL-Nornicotine, (R,S)-Nornicotine

     (±)-Nornicotine is a metabolite of nicotine that acts as a neuronal nicotinic acetylcholine receptor (nAChR) agonist. (±)-Nornicotine Chemical Structure
  99. GC49482 (±)-Nornicotine-d4

    DL-Nornicotine-d4, (R,S)-Nornicotine-d4

     An internal standard for the quantification of (±)-nornicotine (±)-Nornicotine-d4 Chemical Structure
  100. GC12394 (±)-trans-ACPD

    Trans-(±)-ACP

    metabotropic glutamate receptors agonist

     (±)-trans-ACPD Chemical Structure
  101. GC11128 (±)-Vesamicol hydrochloride

    (±)-AH5183 hydrochloride

     acetylcholine transport inhibitor (±)-Vesamicol hydrochloride Chemical Structure

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