GLPBio

Bevenopran (CB-5945)

Catalog No.: GC30639Purity:>98%Synonyms: CB-5945; ADL-5945
COASDSData Sheet
Bevenopran (CB-5945) is a peripheral μ-opioid receptor antagonist.

Products are for research use only. Not for human use. We do not sell to patients.

Bevenopran (CB-5945)
Cas No.: 676500-67-7
10mM (in 1mL DMSO)In Stock
$221.00
1
1mgIn Stock
$111.00
1
5mgIn Stock
$260.00
1
10mgIn Stock
$372.00
1
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Citations

No citations are currently available for this product. Below are selected publications citing GlpBio products.
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    Nature
    641, 529–536 (2025)
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    628, 630–638 (2024)
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    632, 686–694 (2024)
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    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
  • Science cover
    Science
    388(6745) (2025)
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    387(6739) (2025)
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    387(6734) (2025)
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    Cell Research
    35, 97–116 (2025)
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    34, 683–706 (2024)
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    33, 273–287 (2023)
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    33, 546–561 (2023)
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    33, 904–922 (2023)
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    31, 1291–1307 (2021)

Description

Bevenopran is a peripheral μ-opioid receptor antagonist.

Bevenopran is a peripheral μ-opioid receptor antagonist. Bevenopran is currently under investigation for the treatment of opioid-induced bowel dysfunction (OBD)[1]. Bevenopran tends to increase bowel movement (BM) frequency, especially for 0.1 mg twice daily and 4 mg daily, respectively[1].

[1]. Diego L, et al. Novel opioid antagonists for opioid-induced bowel dysfunction. Expert Opin Investig Drugs. 2011 Aug;20(8):1047-56. [2]. Siemens W, et al. Advances in pharmacotherapy for opioid-induced constipation - a systematic review. Expert Opin Pharmacother. 2015 Mar;16(4):515-32.

Chemical Properties

CAS No.
676500-67-7
Synonyms
CB-5945; ADL-5945
SMILES
O=C(C1=NC=C(OC2=CC=C(CNCCC3CCOCC3)C=C2OC)N=C1)N
Molecular Formula
C20H26N4O4
Molecular Weight
386.44
Solubility
DMSO : 125 mg/mL (323.47 mM; Need ultrasonic)
Storage
Store at -20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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