GLPBio

Boldine

Catalog No.: GC40876Purity:>99.50%Synonyms: (+)-(S)-Boldine, 2,9-Dihydroxy-1,10-dimethoxyaporphine, NSC 65689
COASDSData Sheet
Boldine is an aporphine alkaloid, first extracted from the leaves and bark of P.

Products are for research use only. Not for human use. We do not sell to patients.

Boldine
Cas No.: 476-70-0
10mM (in 1mL DMSO)In Stock
$31.00
1
5mgIn Stock
$28.00
1
10mgIn Stock
$39.00
1
25mgIn Stock
$70.00
1
50mgIn Stock
$113.00
1
100mgIn Stock
$181.00
1
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Citations

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    641, 529–536 (2025)
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    632, 686–694 (2024)
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    618, 1017–1023 (2023)
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    610, 366–372 (2022)
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    Cell
    187(9):2288-2304 (2024)
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    Cell
    183(7):1867-1883 (2020)
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    388(6745) (2025)
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    35, 97–116 (2025)
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    34, 683–706 (2024)
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    33, 904–922 (2023)
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    31, 1291–1307 (2021)

Description

Boldine is an aporphine isoquinoline alkaloid extracted from the root of Litsea cubeba and also possesses these properties, including antioxidant, anti-inflammatory and cytoprotective effects. Boldine suppresses osteoclastogenesis, improves bone destruction by down-regulating the OPG/RANKL/RANK signal pathway and may be a potential therapeutic agent for rheumatoid arthritis[1].

References:
[1]. Zhao H , et al. Boldine isolated from Litsea cubeba inhibits bone resorption by suppressing the osteoclast differentiation in collagen-induced arthritis. Int Immunopharmacol. 2017 Oct;51:114-123.

Product Documents

Purity:>99.50%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
476-70-0
Synonyms
(+)-(S)-Boldine, 2,9-Dihydroxy-1,10-dimethoxyaporphine, NSC 65689
SMILES
OC1=C(OC)C2=C3[C@](N(C)CCC3=C1)([H])CC4=CC(O)=C(OC)C=C42
Molecular Formula
C19H21NO4
Molecular Weight
327.4
Solubility
DMF: 50 mg/mL,DMSO: 50 mg/mL,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/mL,Ethanol: 30 mg/mL
Storage
Store at -20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

Reviews

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