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Bradykinin Receptors

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Bradykinin is a potent vasodilator peptide that exerts its vasodilatory action through stimulation of specific endothelial B2 receptors, thereby causing the release of prostacyclin, NO, and EDHF.

Bradykinin (BK) has been reported to be involved in the progression of many types of cancer. Two bradykinin receptors, bradykinin B1 receptor (B1R) and bradykinin B2 receptor (B2R), are significantly expressed in all the tested colorectal cancer cells. Repression of B2R, but not B1R, attenuates the BK-mediated invasion and migration, and inhibits ERK1/2 activation and IL-6 production. Moreover, blocking of the ERK pathway decreases the BK-mediated IL-6 production. In addition, IL-6 repression suppresses the effects of BK on colorectal cancer cell invasion and migration.

Bradykinin, the enzymatic product of kallikrein-kinin system (KKS), is a major modulator of Ang II actions on blood volume, vascular reactivity and salt sensitivity.

Products Related to Bradykinin Receptors(29)

  • GA20221 structure
    GA20221(Hyp³)-Bradykinin
    CAS: 37642-65-2
    Purity: >98%

    (Hyp³)-Bradykinin, naturally occurring peptide hormone, is a bradykinin receptor agonist.

  • GC10255 structure
    GC10255Lys-[Des-Arg9]Bradykinin
    CAS: 71800-36-7
    Purity: >98%

    bradykinin B1 receptor agonist

  • GC11961 structure
    GC11961Sar-[D-Phe8]-des-Arg9-Bradykinin
    CAS: 126959-88-4
    Purity: >99.00%

    selective bradykinin B1 receptor agonist

  • GC13179 structure
    GC13179R 892
    CAS: 229030-05-1
    Purity: >98%

    bradykinin B1 receptor antagonist

  • GC14629 structure
    GC14629Bombinakinin-GAP
    CAS: 573671-91-7
    Purity: >98%

    Bioactive bradykinin-related peptide

  • GC15188 structure
    GC15188MEN 11270
    CAS: 235082-52-7
    Purity: >98%

    B2 bradykinin receptor antagonist

  • GC15587 structure
    GC15587HOE 140
    CAS: 130308-48-4
    Purity: >98.50%

    HOE 140 (HOE-140) is a potent and specific peptide antagonist of bradykinin B2 receptor with IC50 and Ki of 1.07 nM and 0.798 nM respectively.

  • GC16110 structure
    GC16110R 715
    CAS: 185052-09-9
    Purity: >98%

    bradykinin B1 receptor antagonist

  • GC16761 structure
    GC16761Bombinakinin M
    CAS: 509151-65-9
    Purity: >98%

    Potent bradykinin receptor agonist

  • GC16820 structure
    GC16820ELN441958
    CAS: 913064-47-8
    Purity: >98.00%

    ELN441958 is a potent, competitive, and selective bradykinin B1 receptor antagonist with a K i value of 0.26nM.

  • GC17164 structure
    GC17164Lys-Bradykinin
    CAS: 342-10-9
    Purity: >98%

    Endogenous bradykinin receptor agonist

  • GC17933 structure
    GC17933WIN 64338 hydrochloride
    CAS: 163727-74-0
    Purity: >98%

    bradykinin B2 receptor antagonist, competitive

  • GC18038 structure
    GC18038[Phe8Ψ(CH-NH)-Arg9]-Bradykinin
    CAS: 118122-39-7
    Purity: >98%

    Selective bradykinin B2 receptor agonist

  • GC19339 structure
    GC19339SSR240612
    CAS: 464930-42-5
    Purity: >95.00%

    SSR240612 is a new, potent, and orally active specific non-peptide bradykinin B1 receptor antagonist, which inhibited Lys0-desAr9-BK (10nM)-induced inositol monophosphate formation in human fibroblast MRC5, with an IC 50 of 1.9nM.

  • GC31926 structure
    GC31926FR167344 free base
    CAS: 215258-13-2
    Purity: >98%

    FR167344 free base is an orally active, nonpeptide bradykinin receptor B2 antagonist.

  • GC32576 structure
    GC32576Bradykinin 1-3
    CAS: 23815-91-0
    Purity: >98%

    Bradykinin 1-3 is a 3-amino acid residue peptide.

  • GC32592 structure
    GC32592Bradykinin 1-5
    CAS: 23815-89-6
    Purity: >99.00%

    Bradykinin 1-5 is a major stable metabolite of Bradykinin, formed by the proteolytic action of angiotensin-converting enzyme (ACE).

  • GC32601 structure
    GC32601Bradykinin 1-7 (Bradykinin Fragment 1-​7)
    CAS: 23815-87-4
    Purity: >98%

    Bradykinin 1-7 (Bradykinin Fragment 1-​7) is an amino-truncated Bradykinin peptide.

  • GC32605 structure
    GC32605Bradykinin 1-6
    CAS: 23815-88-5
    Purity: >98.50%

    Bradykinin 1-6 is an amino-truncated Bradykinin peptide.

  • GC33850 structure
    GC33850[Des-Arg9]-Bradykinin acetate
    CAS: 23827-91-0
    Purity: >98%

    [Des-Arg9]-Bradykinin acetate is a Bradykinin B1 receptor agonist that displays selectivity for B1 over B2 receptors.

  • GC34042 structure
    GC34042Bradykinin 2-9 (Des-Arg1-bradykinin)
    CAS: 16875-11-9
    Purity: >99.50%

    Bradykinin 2-9 (Des-Arg1-bradykinin) is an amino-truncated Bradykinin peptide.

  • GC35015 structure
    GC35015[Des-Arg9]-Bradykinin
    CAS: 15958-92-6
    Purity: >98.00%

    [Des-Arg9]-Bradykinin is a Bradykinin (B1) receptor agonist that displays selectivity for B1 over B2 receptors.

  • GC35548 structure
    GC35548Bradykinin
    CAS: 58-82-2
    Purity: >98.00%

    Bradykinin is a potent vasodilator peptide that exerts the vasodilatory action through stimulation of specific endothelial B2 receptors, thereby causing the release of prostacyclin, NO, and Endothelium-derived hyperpolarization factor.

  • GC43888 structure
    GC43888Icatibant (acetate)
    CAS: 138614-30-9
    Purity: >99.50%

    Icatibant is a synthetic peptide antagonist of the bradykinin B2 receptor with IC50 and Ki values of 1.07 and 0.798 nM, respectively, in guinea pig ileal cell membranes.