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Home >> Signaling Pathways >> GPCR/G protein

GPCR/G protein

Products for  GPCR/G protein

  1. Cat.No. Product Name Information
  2. GC66088 α-Helical CRF(9-41) TFA α-Helical CRF(9-41) TFA is a competitive CRF2 receptor antagonist with KB of ~100 nM. α-Helical CRF(9-41) TFA is also a partial agonist of CRF1 receptor with an EC50 of 140 nM. α-Helical CRF(9-41) TFA Chemical Structure
  3. GC64563 α-Methylserotonin α-Methylserotonin Chemical Structure
  4. GC38007 β-Melanocyte Stimulating Hormone (MSH), human TFA

    Beta-MSH (1-22) (human) TFA

     β-Melanocyte Stimulating Hormone (MSH), human TFA Chemical Structure
  5. GC37983 β3-AR agonist 1 β3-AR agonist 1 (compound 15) is a highly potent, selective, and orally available β3-adrenergic receptor (β3-AR) agonist (EC50=18 nM), being inactive to β1-, β2-, and α1A-AR (β1/β3, β2/β3, and α1A/β3>556-fold). β3-AR agonist 1 Chemical Structure
  6. GC40105 βARK1 Inhibitor βARK1 Inhibitor (methyl 5-[2-(5-nitro-2-furyl)vinyl]-2-furoate) is a GRK2 (β-ARK1) inhibitor. βARK1 Inhibitor Chemical Structure
  7. GC61462 γ-1-Melanocyte Stimulating Hormone (MSH), amide γ-1-Melanocyte Stimulating Hormone (MSH), amide Chemical Structure
  8. GC17002 γ1-MSH γ1-MSH is a melanocortin MC3 receptor agonist, with a Ki of 34 nM for the rat MC3 receptor. γ1-MSH Chemical Structure
  9. GC62708 σ1 Receptor antagonist-1 σ1 Receptor antagonist-1 is a highly potent and selective sigma 1 receptor antagonist (pKi=10.28). σ1 Receptor antagonist-1 Chemical Structure
  10. GC15519 α-CGRP (human)

    Endogenous calcitonin gene-related peptide receptor (CGRP) agonist

     α-CGRP (human) Chemical Structure
  11. GC11346 α-helical CRF 9-41 Antagonist of corticotropin releasing factor receptor α-helical CRF 9-41 Chemical Structure
  12. GC11577 α-Methyl-5-hydroxytryptamine maleate

    α-Me-5-HT, α-Methyl-5-HT, α-Methyl-5-hydroxytryptamine, α-Methylserotonin

     5-HT2B receptor agonist α-Methyl-5-hydroxytryptamine maleate Chemical Structure
  13. GC31237 α1 adrenoceptor-MO-1 α1 adrenoceptor-MO-1, an S enantiomer, has affinity at alpha 1 adrenergic receptor, shows alphalytic activity, and possesses analgesic action; more active than R enantiomer. α1 adrenoceptor-MO-1 Chemical Structure
  14. GC33693 β-Melanocyte Stimulating Hormone (MSH), human (Beta-MSH (1-22) (human)) β-Melanocyte Stimulating Hormone (MSH), human (Beta-MSH (1-22) (human)), a 22-residue peptide, acts as an endogenous melanocortin-4 receptor (MC4-R) agonist. β-Melanocyte Stimulating Hormone (MSH), human (Beta-MSH (1-22) (human)) Chemical Structure
  15. GC31573 β3-AR agonist 2 β3-AR agonist 2 is a potent and selective β3-adrenergic receptor (β3-AR) agonist with an EC50 of 8 nM. β3-AR agonist 2 Chemical Structure
  16. GC34231 γ-1-Melanocyte Stimulating Hormone (MSH), amide γ-1-Melanocyte Stimulating Hormone (MSH), amide Chemical Structure
  17. GC17413 (±)-5'-Chloro-5'-deoxy-ENBA adenosine A1 receptor agonist, selective and high-affinity (±)-5'-Chloro-5'-deoxy-ENBA Chemical Structure
  18. GC17408 (±)-AC 7954 hydrochloride urotensin-II (UT) receptor agonist (±)-AC 7954 hydrochloride Chemical Structure
  19. GC15045 (±)-AMG 487 CXCR3 antagonist (±)-AMG 487 Chemical Structure
  20. GC41668 (±)-Clopidogrel (hydrochloride) Clopidogrel is an antithrombic compound whose active metabolite is a selective, irreversible antagonist of the platelet purinergic P2Y12 receptor (IC50 = 100 nM). (±)-Clopidogrel (hydrochloride) Chemical Structure
  21. GC16838 (±)-Cloprostenol sodium salt

    (±)16mchlorophenoxy tetranor PGF2α, (±)16mchlorophenoxy tetranor Prostaglandin F2α, DLCloprostenol

    prostaglandin F2α (PGF2α) analog,FP receptor agonist

     (±)-Cloprostenol sodium salt Chemical Structure
  22. GC46283 (±)-Clorprenaline-d7

    Isoprophenamine-d7

     A neuropeptide with diverse biological activities (±)-Clorprenaline-d7 Chemical Structure
  23. GC18090 (±)-J 113397 NOP receptor antagonist (±)-J 113397 Chemical Structure
  24. GC62727 (±)-Penbutolol-d9 hydrochloride (±)-Penbutolol-d9 ((Rac)-Penbutolol-d9) hydrochloride is a deuterium labeled (±)-Penbutolol hydrochloride. (±)-Penbutolol-d9 hydrochloride Chemical Structure
  25. GC15144 (±)-PPCC oxalate sigma (σ) receptor ligand (±)-PPCC oxalate Chemical Structure
  26. GC10907 (±)-SLV 319

    (±)-SLV319; (±)-BMS-646256

     (±)-SLV 319 ((±)-SLV319) is the racemate of SLV319. (±)-SLV 319 Chemical Structure
  27. GC12394 (±)-trans-ACPD

    Trans-(±)-ACP

    metabotropic glutamate receptors agonist

     (±)-trans-ACPD Chemical Structure
  28. GC67681 (αR,8aS)-GSK1614343 (αR,8aS)-GSK1614343 Chemical Structure
  29. GC32523 (±)-Befunolol (±)-Befunolol is a β-adrenoceptor blocking agent. (±)-Befunolol Chemical Structure
  30. GC34957 (+)-Cevimeline hydrochloride hemihydrate

    (-)-SNI-2011; (-)-AF102B hydrochloride hemihydrate

     (+)-Cevimeline hydrochloride hemihydrate ((+)-SNI-2011), a potent muscarinic receptor agonist, is a candidate therapeutic drug for xerostomia in Sjogren's syndrome. (+)-Cevimeline hydrochloride hemihydrate Chemical Structure
  31. GC30743 (+)-Cloprostenol (D-Cloprostenol)

    DCloprostenol, (+)16mchlorophenoxy tetranor PGF2α, (+)16mchlorophenoxy tetranor Prostaglandin F2α

     (+)-Cloprostenol (D-Cloprostenol) is a prostaglandin F2α (PGF2α) analogue, and shows selective agonistic activity at the prostaglandin receptor. (+)-Cloprostenol (D-Cloprostenol) Chemical Structure
  32. GC45259 (+)-Cloprostenol (sodium salt)

    DCloprostenol, (+)16mchlorophenoxy tetranor PGF2α, (+)16mchlorophenoxy tetranor Prostaglandin F2α

     (+)-Cloprostenol (sodium salt) is a more water soluble, crystalline form of (+)-cloprostenol. (+)-Cloprostenol (sodium salt) Chemical Structure
  33. GC12750 (+)-Fluprostenol

    16mtrifluoromethylphenoxy tetranor Prostaglandin F2α

     Prostaglandin F2α (FP) receptor agonist (+)-Fluprostenol Chemical Structure
  34. GC18146 (+)-Igmesine hydrochloride σ1 receptor ligand (+)-Igmesine hydrochloride Chemical Structure
  35. GC68210 (+)-Norfenfluramine (+)-Norfenfluramine Chemical Structure
  36. GC31597 (+)-Penbutolol ((R)-Penbutolol)

    (R)-Penbutolol; (+)-Isopenbutolol

     (+)-Penbutolol ((R)-Penbutolol) is a β-adrenoceptor antagonist, with an IC50 of 0.74 μM. (+)-Penbutolol ((R)-Penbutolol) Chemical Structure
  37. GC17301 (+)-SK&F 10047 hydrochloride prototypical σ1 receptor agonist (+)-SK&F 10047 hydrochloride Chemical Structure
  38. GC10675 (+,-)-Octopamine HCl

    β,4-Dihydroxyphenethylamine, Epirenor, Norfen, NSC 108685, (±)-4-Octopamine, (±)-p-Octopamine

     Octopamine ((±)-p-Octopamine) hydrochloride, a biogenic monoamine structurally related to noradrenaline, acts as a neurohormone, a neuromodulator and a neurotransmitter in invertebrates. (+,-)-Octopamine HCl Chemical Structure
  39. GC50245 (+/-)-ADX 71743 Negative allosteric modulator of mGlu7 receptors; brain penetrant (+/-)-ADX 71743 Chemical Structure
  40. GC50048 (+/-)-PPCC oxalate Selective sigma (σ) agonist (σ1> σ2) (+/-)-PPCC oxalate Chemical Structure
  41. GC61646 (-)-Camphoric acid (-)-Camphoric acid Chemical Structure
  42. GC70383 (-)-Vesamicol (-)-Vesamicol (AH5183) is an inhibitor of acetylcholine transport into synaptic vesicles, with the IC50 of 75 nM. (-)-Vesamicol Chemical Structure
  43. GC16919 (1R,1'S,3'R/1R,1'R,3'S)-L-054,264 somatostatin sst2 receptor agonist (1R,1'S,3'R/1R,1'R,3'S)-L-054,264 Chemical Structure
  44. GC34963 (1R,2S)-VU0155041 (1R,2S)-VU0155041, Cis regioisomer of VU0155041, is a partial mGluR4 agonist with an EC50 of 2.35 μM. (1R,2S)-VU0155041 Chemical Structure
  45. GC70349 (1S)-CCR2 antagonist 1 (1S)-CCR2 antagonist 1 is a left-handed chiral body of CCR2 antagonist 1 . (1S)-CCR2 antagonist 1 Chemical Structure
  46. GC34965 (20S)-Protopanaxatriol

    20(S)-APPT, 20(S)-PPT

     An active ginsenoside metabolite (20S)-Protopanaxatriol Chemical Structure
  47. GC38712 (2R,3R)-E1R (2R,3R)-E1R (Compound 2b) is an enantiomer of E1R. (2R,3R)-E1R Chemical Structure
  48. GC70784 (2R,3R)-Firazorexton (2R,3R)-Firazorexton ((2R,3R)-TAK-994 free base) is an isomer of Firazorexton . (2R,3R)-Firazorexton Chemical Structure
  49. GC38713 (2R,3S)-E1R (2R,3S)-E1R (Compound 2c) is an enantiomer of E1R. (2R,3S)-E1R Chemical Structure
  50. GC38714 (2S,3S)-E1R (2S,3S)-E1R (Compound 2d) is an enantiomer of E1R. (2S,3S)-E1R Chemical Structure
  51. GC32644 (4E)-SUN9221 (4E)-SUN9221 is a potent antagonist of α1-adrenergic receptor and 5-HT2 receptor, with antihypertensive and anti-platelet aggregation activities. (4E)-SUN9221 Chemical Structure
  52. GA20063 (D-Ala²)-Gastric Inhibitory Polypeptide (human) GIP receptor agonist. (D-Ala²)-Gastric Inhibitory Polypeptide (human) Chemical Structure
  53. GA20084 (Deamino-Cys¹,β-cyclohexyl-Ala⁴,Arg⁸)-Vasopressin Studies revealed that this specific vasopressin agonist exhibited a nanomolar affinity for V-1b receptors from various mammalian species (bovine, human, rat). It exhibited high V-1b/V-1a and V-1b/oxytocin selectivity for rat, human, and bovine receptors. Furthermore, it showed a high V-1b/V-2 specificity for both bovine and human vasopressin receptors. Therefore, d(Cha?)-AVP is a promising tool for research of V-1b receptor structure-function relationships. (Deamino-Cys¹,β-cyclohexyl-Ala⁴,Arg⁸)-Vasopressin Chemical Structure
  54. GC64657 (E/Z)-ZINC09659342 (E/Z)-ZINC09659342 is an inhibitor of Lbc-RhoA interaction. (E/Z)-ZINC09659342 Chemical Structure
  55. GA20195 (Gly¹,Ser³·²²,Gln⁴·³⁴,Thr⁶,Arg¹⁹,Tyr²¹,Ala²³·³¹,Aib³²)-Pancreatic Polypeptide (human) (Gly¹,Ser³.²²,Gln⁴.³⁴,Thr⁶,Arg¹⁹,Tyr²¹,Ala²³.³¹,Aib³²)-Pancreatic Polypeptide (human) is a potent and selective neuropeptide Y Y5 receptor agonist with an IC50 of 0.24 nM for binding to the hY5 receptor. (Gly¹,Ser³·²²,Gln⁴·³⁴,Thr⁶,Arg¹⁹,Tyr²¹,Ala²³·³¹,Aib³²)-Pancreatic Polypeptide (human) Chemical Structure
  56. GA20221 (Hyp³)-Bradykinin (Hyp³)-Bradykinin, naturally occurring peptide hormone, is a bradykinin receptor agonist. (Hyp³)-Bradykinin Chemical Structure
  57. GA20229 (Leu³¹,Pro³⁴)-Neuropeptide Y (human, rat) (Leu³¹,Pro³⁴)-Neuropeptide Y (human, rat) is a specific neuropeptide Y Y1 receptor agonist. (Leu³¹,Pro³⁴)-Neuropeptide Y (human, rat) Chemical Structure
  58. GC11952 (R)-(+)-Atenolol

    (R)-Atenolol

     less active enantiomer of the racemic β1-adrenergic receptor antagonist, (R,S)-atenolol. (R)-(+)-Atenolol Chemical Structure
  59. GC11937 (R)-(+)-m-Nitrobiphenyline oxalate α2C-AR (adrenoceptor) agonist (R)-(+)-m-Nitrobiphenyline oxalate Chemical Structure
  60. GC10608 (R)-(+)-Propranolol hydrochloride

    β-adrenoceptor antagonist

     (R)-(+)-Propranolol hydrochloride Chemical Structure
  61. GC11219 (R)-(+)-Tolterodine (R)-(+)-Tolterodine(PNU-200583) is a potent muscarinic receptor antagonists that show selectivity for the urinary bladder over salivary glands in vivo. (R)-(+)-Tolterodine Chemical Structure
  62. GC12144 (R)-(-)-Niguldipine hydrochloride L-type Ca2+ channel blocker and α1A-adrenoceptor antagonist (R)-(-)-Niguldipine hydrochloride Chemical Structure
  63. GC34985 (R)-ADX-47273 (R)-ADX-47273 is a potent mGluR5 positive allosteric modulator, with an EC50 of 168 nM for potentiation . (R)-ADX-47273 Chemical Structure
  64. GC60001 (R)-Carvedilol (R)-Carvedilol ((R)-BM 14190), the R-enantiomer of Carvedilol, is a non-selective β/α-1 blocker. (R)-Carvedilol Chemical Structure
  65. GC69805 (R)-Casopitant

    (R)-GW679769

    (R)-Casopitant ((R)-GW679769) is an isomer of Casopitant. Casopitant is an NK(1) receptor antagonist that can be used in the research of chemotherapy-induced nausea and vomiting.

     (R)-Casopitant Chemical Structure
  66. GC67937 (R)-Mirtazapine

    (R)-Org3770; (R)-6-Azamianserin

     (R)-Mirtazapine Chemical Structure
  67. GC71634 (R)-Oxybutynin hydrochloride (R)-Oxybutynin drochloride, a (R)-isomer of Oxybutynin drochloride, is an orally active muscarinic receptor antagonist. (R)-Oxybutynin hydrochloride Chemical Structure
  68. GC10028 (R)-SLV 319 CB1 receptor antagonist (R)-SLV 319 Chemical Structure
  69. GC39298 (R)-Terazosin (R)-Terazosin is an active R-enantiomer of Terazosin. (R)-Terazosin Chemical Structure
  70. GC50426 (R)-ZINC 3573 MRGPRX2 agonist (R)-ZINC 3573 Chemical Structure
  71. GC62588 (R,R)-CXCR2-IN-2 (R,R)-CXCR2-IN-2, diastereoisomer of CXCR2-IN-2 (compound 68), is a brain penetrant CXCR2 antagonist with a pIC50 of 9 and 6.8 in the Tango assay and d in the HWB Gro-α induced CD11b expression assay, respectively. (R,R)-CXCR2-IN-2 Chemical Structure
  72. GC14145 (R,R)-Formoterol

    (-)-Formoterol;Arformoterol;Formoterol

     β2-selective adrenergic agonist (R,R)-Formoterol Chemical Structure
  73. GC34995 (R,R)-Palonosetron Hydrochloride (R,R)-Palonosetron Hydrochloride is the active enantiomer of Palonosetron. (R,R)-Palonosetron Hydrochloride Chemical Structure
  74. GC12823 (R,S)-Atenolol

    Duraatenol,IC I66082,Tenormin®

     (R,S)-Atenolol ((RS)-(R,S)-Atenolol) is a cardioselective β1-adrenergic receptor blocker, with a Ki of 697 nM atβ1-adrenoceptor in guine pig left ventricle membrane. (R,S)-Atenolol Chemical Structure
  75. GC63452 (Rac)-5-Hydroxymethyl Tolterodine (Rac)-5-Hydroxymethyl Tolterodine ((Rac)-Desfesoterodine), an active metabolite of Tolterodine, is a mAChR antagonist (Ki values of 2.3 nM, 2 nM, 2.5 nM, 2.8 nM, and 2.9 nM for M1, M2, M3, M4, and M5 receptors, respectively). (Rac)-5-Hydroxymethyl Tolterodine Chemical Structure
  76. GC71582 (Rac)-5-Hydroxymethyl Tolterodine hydrochloride (Rac)-5-droxymetl Tolterodine ((Rac)-Desfesoterodine) drochloride, an active metabolite of Tolterodine, is a mAChR antagonist (Ki values of 2.3 nM, 2 nM, 2.5 nM, 2.8 nM, and 2.9 nM for M1, M2, M3, M4, and M5 receptors, respectively). (Rac)-5-Hydroxymethyl Tolterodine hydrochloride Chemical Structure
  77. GC19541 (rac)-Antineoplaston A10

    (rac)-Antineoplaston A10 is the racemate of Antineoplaston A10

     (rac)-Antineoplaston A10 Chemical Structure
  78. GC64481 (rac)-Dobutamine-d4 hydrochloride (rac)-Dobutamine-d4 hydrochloride Chemical Structure
  79. GC62642 (rac)-Dobutamine-d6 hydrochloride (rac)-Dobutamine-d6 hydrochloride Chemical Structure
  80. GC38721 (Rac)-E1R (Rac)-E1R (Compound 2) is the racemate of E1R. (Rac)-E1R Chemical Structure
  81. GC63410 (Rac)-MRI-1867

    (Rac)-MRI-1867

     (Rac)-MRI-1867 ((Rac)-MRI-1867, compound 6b) is a cannabinoid receptor type 1 (CB1R)/iNOS antagonist, with a Ki of 5.7 nM for CB1R. (Rac)-MRI-1867 Chemical Structure
  82. GC62228 (rac)-Nebivolol-d4 (Rac)-Nebivolol-d4 ((Rac)-R 065824-d4) is a labelled racemic Nebivolol. (rac)-Nebivolol-d4 Chemical Structure
  83. GC64905 (Rac)-Upacicalcet (Rac)-Upacicalcet is the racemate of Upacicalcet. (Rac)-Upacicalcet Chemical Structure
  84. GC71532 (rel)-Eglumegad (rel)-Eglumegad ((rel)-LY354740) is a relative configuration of Eglumegad . (rel)-Eglumegad Chemical Structure
  85. GC34367 (RS)-Butyryltimolol (RS)-Butyryltimolol is the racemate of Butyryltimolol. (RS)-Butyryltimolol Chemical Structure
  86. GC12279 (RS)-MCPG

    alpha-MCPG

     mGluR antagonist (RS)-MCPG Chemical Structure
  87. GC15292 (S)-(+)-Niguldipine hydrochloride L-type Ca2+ channel blocker and α1A-adrenoceptor antagonist (S)-(+)-Niguldipine hydrochloride Chemical Structure
  88. GC12463 (S)-(-)-Atenolol

    β-adrenergic blocker

     (S)-(-)-Atenolol Chemical Structure
  89. GC15039 (S)-(-)-Pindolol beta-adrenergic antagonist (S)-(-)-Pindolol Chemical Structure
  90. GC16637 (S)-(-)-Propranolol hydrochloride β-adrenoceptor antagonist (S)-(-)-Propranolol hydrochloride Chemical Structure
  91. GC60006 (S)-Carvedilol (S)-Carvedilol, the S-enantiomer of Carvedilol, is a non-selective β/α-1 blocker. (S)-Carvedilol Chemical Structure
  92. GC71271 (S)-FTY720-phosphonate FTY720 (S)-Phosphate is an agonist of S1P receptor 1 (S1PR1), used in the research of acute inflammatory diseases such as acute lung injury. (S)-FTY720-phosphonate Chemical Structure
  93. GC69904 (S)-JDQ-443

    (S)-NVP-JDQ443

    (S)-JDQ-443 is an isomer of JDQ-443. JDQ-443 is an orally effective and selective covalent KRAS G12C inhibitor. JDQ-443 has anti-tumor activity.

     (S)-JDQ-443 Chemical Structure
  94. GC35002 (S)-Mapracorat

    (S)-ZK-245186; (S)-BOL-303242X

     (S)-Mapracorat is a selective and less active glucocorticoid receptor agonist. (S)-Mapracorat Chemical Structure
  95. GC16349 (S)-MCPG

    (+)-α-methyl-4-Carboxyphenylglycine, (S)-α-methyl-4-Carboxyphenylglycine, (+)-MCPG

     mGluR antagonist (S)-MCPG Chemical Structure
  96. GC67989 (S)-Mirtazapine

    (S)-Org3770; (S)-6-Azamianserin

     (S)-Mirtazapine Chemical Structure
  97. GC68410 (S)-Mirtazapine-d3

    (S)-Org3770 D3; (S)-6-Azamianserin D3

     (S)-Mirtazapine-d3 Chemical Structure
  98. GC70925 (S)-Osanetant (S)-Osanetant is the S-enantiomer of Osanetant. (S)-Osanetant Chemical Structure
  99. GC69941 (S)-Renzapride

    (S)-BRL 24924

    (S)-Renzapride ((S)-BRL 24924) is an isomer of Renzapride. Renzapride is a 5-HT4 receptor agonist with a Ki value of 115 nM. It also acts as an antagonist for the 5HT2b and 5HT3 receptors. Renzapride can be used in research on constipation-predominant irritable bowel syndrome (C-IBS).

     (S)-Renzapride Chemical Structure
  100. GC10753 (S)-SLV 319

    Ibipinabant|BMS 646256|JD 5001

     (S)-SLV 319 (SLV319) is a potent, selective and orally active antagonist of cannabinoid CB1 receptor, with a Ki of 7.8 nM. (S)-SLV 319 Chemical Structure
  101. GC39249 (S)-Terazosin (S)-Terazosin is an active S-enantiomer of Terazosin. (S)-Terazosin Chemical Structure

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