GPCR/G protein
- Neuropeptide FF/AF Receptors(49)
- Neuropeptide S Receptor(1)
- GPBA Receptor(1)
- Trace Amine 1 Receptor(2)
- GPCR protein(1)
- FFAR3(1)
- Formyl Peptide Receptors(11)
- 5-HT Receptor(403)
- Acetylcholine(29)
- Adenosine Deaminase(10)
- Adenosine Receptor(131)
- Adenosine Kinase(4)
- Adiponectin Receptor(3)
- Adrenergic Receptor(422)
- Adrenergic Transporters(5)
- Apelin Receptor(9)
- Angiotensin Receptor(114)
- Bombesin Receptors(23)
- Bradykinin Receptors(29)
- Calcitonin and Related Receptors(10)
- Cannabinoid Receptor(141)
- Calcimimetic Agent(2)
- CaSR(20)
- CCK1 Receptors(7)
- CCK2 Receptors(7)
- CCR(81)
- Chemokine Receptors(25)
- CRF1 Receptors(9)
- CRF2 Receptors(3)
- CXCR(81)
- CysLT1 receptor(1)
- Endothelin Receptor(50)
- EP1 Receptor(2)
- EP4 Receptor(2)
- ERRγ(1)
- ETA Receptors(5)
- ETB Receptors(5)
- Free Fatty Acid Receptors(18)
- Galanin Receptors(11)
- Ghrelin Receptors(12)
- GHSR(19)
- GIP Receptor(5)
- Glucagon Receptor(61)
- Glucocorticoid Receptor(97)
- GLUT1(1)
- Gonadotropin-Releasing Hormone Receptors(3)
- GPCR19(12)
- GPR109A(4)
- GPR119(10)
- GPR120(9)
- GPR35(10)
- GPR44(1)
- GPR55(11)
- Hydroxycarboxylic Acid Receptors(5)
- Leukotriene Receptor(58)
- LPA Receptor(12)
- LPL Receptor(60)
- LTD4 Receptor(1)
- mGluR (119)
- Melanin-concentrating Hormone Receptors(7)
- Melanocortin (MC) Receptors(58)
- Melatonin Receptors(23)
- Motilin Receptor(7)
- MT Receptor(1)
- Non-selective CRF(7)
- Neurotensin Receptors(24)
- NK2 Receptors(7)
- NK3 Receptor(5)
- NOP Receptor(21)
- NPY Receptors(28)
- Orexin(3)
- Orphan 7-TM Receptors(6)
- OX Receptor(47)
- Oxytocin Receptors(22)
- P2Y Receptor(62)
- PACAP Receptors(3)
- PAF Receptors(8)
- Peptide Receptors(15)
- PGD2 Receptor(1)
- Prostaglandin Receptor(171)
- Prostanoid Receptors(25)
- Protease-Activated Receptors(10)
- RGS(2)
- S1P receptor(8)
- Secretin Receptors(1)
- Sensory Neuron-Specific Receptors(1)
- Somatostatin Receptor(39)
- Sigma Receptor(59)
- Vasopressin Receptor(36)
- 17,20-lyase(5)
- Ras(142)
- Urotensin-II Receptor(11)
- VIP Receptors(7)
- EBI2/GPR183(7)
- TSH Receptor(11)
- NK Receptor(1)
- GPR81(1)
- C3aR(1)
- CysLT2 receptor(1)
- S1P receptor inhibitor(22)
- CCKB(1)
- FFAR1 (GPR40)(20)
- GPR84(8)
- Neuromedin U Receptors(2)
- Kisspeptin Receptor(5)
- CRFR(25)
- RGS Protein(5)
- Urotensin Receptor(6)
- Cholecystokinin Receptor(25)
- GPR139(4)
- mAChR(185)
- MCHR1 (GPR24)(16)
- Neurokinin Receptor(75)
- cGMP(27)
- GRK(1)
- GPR88(0)
- Amylin Receptor(0)
- Arrestin(0)
- Mas-related G-protein-coupled Receptor (MRGPR)(0)
- GCGR(2)
- GLP Receptor(2)
- Succinate Receptor 1(0)
- PTHR(1)
- Protease Activated Receptor (PAR)(2)
- Free Fatty Acid Receptor(1)
- Formyl Peptide Receptor (FPR)(1)
Products for GPCR/G protein
- Cat.No. Product Name Information
-
GC66088
α-Helical CRF(9-41) TFA
α-Helical CRF(9-41) TFA is a competitive CRF2 receptor antagonist with KB of ~100 nM. α-Helical CRF(9-41) TFA is also a partial agonist of CRF1 receptor with an EC50 of 140 nM.
-
GC64563
α-Methylserotonin
-
GC72123
β-Melanocyte Stimulating Hormone (MSH), human TFA
β-Melanocyte Stimulating Hormone (MSH), human TFA, a 22-residue peptide, acts as an endogenous melanocortin-4 receptor (MC4-R) agonist.
-
GC38007
β-Melanocyte Stimulating Hormone (MSH), human TFA
Beta-MSH (1-22) (human) TFA
-
GC37983
β3-AR agonist 1
β3-AR agonist 1 (compound 15) is a highly potent, selective, and orally available β3-adrenergic receptor (β3-AR) agonist (EC50=18 nM), being inactive to β1-, β2-, and α1A-AR (β1/β3, β2/β3, and α1A/β3>556-fold).
-
GC40105
βARK1 Inhibitor
βARK1 Inhibitor (methyl 5-[2-(5-nitro-2-furyl)vinyl]-2-furoate) is a GRK2 (β-ARK1) inhibitor.
-
GC17002
γ1-MSH
γ1-MSH is a melanocortin MC3 receptor agonist, with a Ki of 34 nM for the rat MC3 receptor.
-
GC62708
σ1 Receptor antagonist-1
σ1 Receptor antagonist-1 is a highly potent and selective sigma 1 receptor antagonist (pKi=10.28).
-
GC15519
α-CGRP (human)
Endogenous calcitonin gene-related peptide receptor (CGRP) agonist
-
GC11346
α-helical CRF 9-41
Antagonist of corticotropin releasing factor receptor
-
GC11577
α-Methyl-5-hydroxytryptamine maleate
α-Me-5-HT, α-Methyl-5-HT, α-Methyl-5-hydroxytryptamine, α-Methylserotonin
5-HT2B receptor agonist -
GC31237
α1 adrenoceptor-MO-1
α1 adrenoceptor-MO-1, an S enantiomer, has affinity at alpha 1 adrenergic receptor, shows alphalytic activity, and possesses analgesic action; more active than R enantiomer.
-
GC33693
β-Melanocyte Stimulating Hormone (MSH), human (Beta-MSH (1-22) (human))
β-Melanocyte Stimulating Hormone (MSH), human (Beta-MSH (1-22) (human)), a 22-residue peptide, acts as an endogenous melanocortin-4 receptor (MC4-R) agonist.
-
GC31573
β3-AR agonist 2
β3-AR agonist 2 is a potent and selective β3-adrenergic receptor (β3-AR) agonist with an EC50 of 8 nM.
-
GC17413
(±)-5'-Chloro-5'-deoxy-ENBA
adenosine A1 receptor agonist, selective and high-affinity
-
GC17408
(±)-AC 7954 hydrochloride
urotensin-II (UT) receptor agonist
-
GC41668
(±)-Clopidogrel (hydrochloride)
Clopidogrel is an antithrombic compound whose active metabolite is a selective, irreversible antagonist of the platelet purinergic P2Y12 receptor (IC50 = 100 nM).
-
GC16838
(±)-Cloprostenol sodium salt
(±)16mchlorophenoxy tetranor PGF2α, (±)16mchlorophenoxy tetranor Prostaglandin F2α, DLCloprostenol
prostaglandin F2α (PGF2α) analog,FP receptor agonist
-
GC46283
(±)-Clorprenaline-d7
Isoprophenamine-d7
A neuropeptide with diverse biological activities -
GC18090
(±)-J 113397
NOP receptor antagonist
-
GC62727
(±)-Penbutolol-d9 hydrochloride
(±)-Penbutolol-d9 ((Rac)-Penbutolol-d9) hydrochloride is a deuterium labeled (±)-Penbutolol hydrochloride.
-
GC15144
(±)-PPCC oxalate
sigma (σ) receptor ligand
-
GC10907
(±)-SLV 319
(±)-SLV319; (±)-BMS-646256
(±)-SLV 319 ((±)-SLV319) is the racemate of SLV319. -
GC12394
(±)-trans-ACPD
Trans-(±)-ACP
metabotropic glutamate receptors agonist
-
GC67681
(αR,8aS)-GSK1614343
-
GC32523
(±)-Befunolol
(±)-Befunolol is a β-adrenoceptor blocking agent.
-
GC34957
(+)-Cevimeline hydrochloride hemihydrate
(-)-SNI-2011; (-)-AF102B hydrochloride hemihydrate
(+)-Cevimeline hydrochloride hemihydrate ((+)-SNI-2011), a potent muscarinic receptor agonist, is a candidate therapeutic drug for xerostomia in Sjogren's syndrome. -
GC30743
(+)-Cloprostenol (D-Cloprostenol)
DCloprostenol, (+)16mchlorophenoxy tetranor PGF2α, (+)16mchlorophenoxy tetranor Prostaglandin F2α
(+)-Cloprostenol (D-Cloprostenol) is a prostaglandin F2α (PGF2α) analogue, and shows selective agonistic activity at the prostaglandin receptor. -
GC45259
(+)-Cloprostenol (sodium salt)
DCloprostenol, (+)16mchlorophenoxy tetranor PGF2α, (+)16mchlorophenoxy tetranor Prostaglandin F2α
(+)-Cloprostenol (sodium salt) is a more water soluble, crystalline form of (+)-cloprostenol. -
GC12750
(+)-Fluprostenol
16mtrifluoromethylphenoxy tetranor Prostaglandin F2α
Prostaglandin F2α (FP) receptor agonist -
GC18146
(+)-Igmesine hydrochloride
σ1 receptor ligand
-
GC68210
(+)-Norfenfluramine
-
GC31597
(+)-Penbutolol ((R)-Penbutolol)
(R)-Penbutolol; (+)-Isopenbutolol
(+)-Penbutolol ((R)-Penbutolol) is a β-adrenoceptor antagonist, with an IC50 of 0.74 μM. -
GC17301
(+)-SK&F 10047 hydrochloride
prototypical σ1 receptor agonist
-
GC10675
(+,-)-Octopamine HCl
β,4-Dihydroxyphenethylamine, Epirenor, Norfen, NSC 108685, (±)-4-Octopamine, (±)-p-Octopamine
Octopamine ((±)-p-Octopamine) hydrochloride, a biogenic monoamine structurally related to noradrenaline, acts as a neurohormone, a neuromodulator and a neurotransmitter in invertebrates. -
GC50245
(+/-)-ADX 71743
Negative allosteric modulator of mGlu7 receptors; brain penetrant
-
GC50048
(+/-)-PPCC oxalate
Selective sigma (σ) agonist (σ1> σ2)
-
GC73658
(-)-5-HT2C agonist-3
(-)-5-HT2C agonist-3 (compound (–)-19) is a 5-HT2C selective agonist with Gq signaling preference, with EC50 values ??for 5-HT2 receptors of 5-HT2C: 103 nM; 5-HT2B: 570 nM; 5-HT2A: 72 nM.
-
GC61646
(-)-Camphoric acid
-
GC74197
(-)-Isoproterenol hydrochloride
Levisoprenaline hydrochloride; Proternol L hydrochloride
(-)-Isoproterenol (Levisoprenaline; Proternol L) drochloride is a β-adrenoceptor agonist. -
GC70383
(-)-Vesamicol
(-)-Vesamicol (AH5183) is an inhibitor of acetylcholine transport into synaptic vesicles, with the IC50 of 75 nM.
-
GC16919
(1R,1'S,3'R/1R,1'R,3'S)-L-054,264
somatostatin sst2 receptor agonist
-
GC34963
(1R,2S)-VU0155041
(1R,2S)-VU0155041, Cis regioisomer of VU0155041, is a partial mGluR4 agonist with an EC50 of 2.35 μM.
-
GC70349
(1S)-CCR2 antagonist 1
(1S)-CCR2 antagonist 1 is a left-handed chiral body of CCR2 antagonist 1 .
-
GC34965
(20S)-Protopanaxatriol
20(S)-APPT, 20(S)-PPT
An active ginsenoside metabolite -
GC73162
(2R,2R)-PF-07258669
(2R,2R)-PF-07258669 is a MC4R (melanocortin 4 receptor) antagonist.
-
GC38712
(2R,3R)-E1R
(2R,3R)-E1R (Compound 2b) is an enantiomer of E1R.
-
GC70784
(2R,3R)-Firazorexton
(2R,3R)-Firazorexton ((2R,3R)-TAK-994 free base) is an isomer of Firazorexton .
-
GC38713
(2R,3S)-E1R
(2R,3S)-E1R (Compound 2c) is an enantiomer of E1R.
-
GC38714
(2S,3S)-E1R
(2S,3S)-E1R (Compound 2d) is an enantiomer of E1R.
-
GC32644
(4E)-SUN9221
(4E)-SUN9221 is a potent antagonist of α1-adrenergic receptor and 5-HT2 receptor, with antihypertensive and anti-platelet aggregation activities.
-
GC73101
(4S)-PROTAC SOS1 degrader-1 diTFA
(4S)-PROTAC SOS1 degrader-1 (diTFA) is a potent PROTAC SOS1 degrader.
-
GA20063
(D-Ala²)-Gastric Inhibitory Polypeptide (human)
GIP receptor agonist.
-
GC64657
(E/Z)-ZINC09659342
(E/Z)-ZINC09659342 is an inhibitor of Lbc-RhoA interaction.
-
GA20195
(Gly¹,Ser³·²²,Gln⁴·³⁴,Thr⁶,Arg¹⁹,Tyr²¹,Ala²³·³¹,Aib³²)-Pancreatic Polypeptide (human)
(Gly¹,Ser³.²²,Gln⁴.³⁴,Thr⁶,Arg¹⁹,Tyr²¹,Ala²³.³¹,Aib³²)-Pancreatic Polypeptide (human) is a potent and selective neuropeptide Y Y5 receptor agonist with an IC50 of 0.24 nM for binding to the hY5 receptor.
-
GA20221
(Hyp³)-Bradykinin
(Hyp³)-Bradykinin, naturally occurring peptide hormone, is a bradykinin receptor agonist.
-
GC72210
(Leu31,Pro34)-Peptide YY (human) (TFA)
(Leu31,Pro34)-Peptide YY (human) (TFA) is the TFA form of (Leu31,Pro34)-Peptide YY (human) .
-
GA20229
(Leu³¹,Pro³⁴)-Neuropeptide Y (human, rat)
(Leu³¹,Pro³⁴)-Neuropeptide Y (human, rat) is a specific neuropeptide Y Y1 receptor agonist.
-
GC72235
(Phenylac1,D-Tyr(Et)2,Lys6,Arg8,des-Gly9)-Vasopressin acetate
(Phenylac1,D-Tyr(Et)2,Lys6,Arg8,des-Gly9)-Vasopressin is a potent vasopressin V1 receptor (VP V1R) antagonist.
-
GC11952
(R)-(+)-Atenolol
(R)-Atenolol
less active enantiomer of the racemic β1-adrenergic receptor antagonist, (R,S)-atenolol. -
GC11937
(R)-(+)-m-Nitrobiphenyline oxalate
α2C-AR (adrenoceptor) agonist
-
GC10608
(R)-(+)-Propranolol hydrochloride
β-adrenoceptor antagonist
-
GC11219
(R)-(+)-Tolterodine
(R)-(+)-Tolterodine(PNU-200583) is a potent muscarinic receptor antagonists that show selectivity for the urinary bladder over salivary glands in vivo.
-
GC12144
(R)-(-)-Niguldipine hydrochloride
L-type Ca2+ channel blocker and α1A-adrenoceptor antagonist
-
GC34985
(R)-ADX-47273
(R)-ADX-47273 is a potent mGluR5 positive allosteric modulator, with an EC50 of 168 nM for potentiation .
-
GC60001
(R)-Carvedilol
(R)-Carvedilol ((R)-BM 14190), the R-enantiomer of Carvedilol, is a non-selective β/α-1 blocker.
-
GC69805
(R)-Casopitant
(R)-GW679769
(R)-Casopitant ((R)-GW679769) is an isomer of Casopitant. Casopitant is an NK(1) receptor antagonist that can be used in the research of chemotherapy-induced nausea and vomiting.
-
GC73737
(R)-GSK866
(R)-GSK866 is the (R)-enantiomer of GSK866.
-
GC67937
(R)-Mirtazapine
(R)-Org3770; (R)-6-Azamianserin
-
GC71634
(R)-Oxybutynin hydrochloride
(R)-Oxybutynin hydrochloride, a (R)-isomer of Oxybutynin hydrochloride, is an orally active muscarinic receptor antagonist.
-
GC72753
(R)-SCH 546738
(R)-SCH 546738 is the R-isomer of SCH 546738.
-
GC10028
(R)-SLV 319
CB1 receptor antagonist
-
GC73187
(R)-Sortilin antagonist 1
(R)-Sortilin antagonist 1 is a sortilin antagonist that blocks the sortilin mediated apoptosis pathway by interfering with the binding of sortilin to its ligand pro-neurotrophin.
-
GC39298
(R)-Terazosin
(R)-Terazosin is an active R-enantiomer of Terazosin.
-
GC50426
(R)-ZINC 3573
MRGPRX2 agonist
-
GC62588
(R,R)-CXCR2-IN-2
(R,R)-CXCR2-IN-2, diastereoisomer of CXCR2-IN-2 (compound 68), is a brain penetrant CXCR2 antagonist with a pIC50 of 9 and 6.8 in the Tango assay and d in the HWB Gro-α induced CD11b expression assay, respectively.
-
GC14145
(R,R)-Formoterol
(-)-Formoterol;Arformoterol;Formoterol
β2-selective adrenergic agonist -
GC34995
(R,R)-Palonosetron Hydrochloride
(R,R)-Palonosetron Hydrochloride is the active enantiomer of Palonosetron.
-
GC12823
(R,S)-Atenolol
Duraatenol,IC I66082,Tenormin®
(R,S)-Atenolol ((RS)-(R,S)-Atenolol) is a cardioselective β1-adrenergic receptor blocker, with a Ki of 697 nM atβ1-adrenoceptor in guine pig left ventricle membrane. -
GC63452
(Rac)-5-Hydroxymethyl Tolterodine
(Rac)-5-Hydroxymethyl Tolterodine ((Rac)-Desfesoterodine), an active metabolite of Tolterodine, is a mAChR antagonist (Ki values of 2.3 nM, 2 nM, 2.5 nM, 2.8 nM, and 2.9 nM for M1, M2, M3, M4, and M5 receptors, respectively).
-
GC71582
(Rac)-5-Hydroxymethyl Tolterodine hydrochloride
(Rac)-5-Hydroxymethyl Tolterodine ((Rac)-Desfesoterodine) hydrochloride, an active metabolite of Tolterodine, is a mAChR antagonist (Ki values of 2.3 nM, 2 nM, 2.5 nM, 2.8 nM, and 2.9 nM for M1, M2, M3, M4, and M5 receptors, respectively).
-
GC19541
(rac)-Antineoplaston A10
(rac)-Antineoplaston A10 is the racemate of Antineoplaston A10
-
GC64481
(rac)-Dobutamine-d4 hydrochloride
-
GC62642
(rac)-Dobutamine-d6 hydrochloride
-
GC38721
(Rac)-E1R
(Rac)-E1R (Compound 2) is the racemate of E1R.
-
GC63410
(Rac)-MRI-1867
(Rac)-MRI-1867
(Rac)-MRI-1867 ((Rac)-MRI-1867, compound 6b) is a cannabinoid receptor type 1 (CB1R)/iNOS antagonist, with a Ki of 5.7 nM for CB1R. -
GC62228
(rac)-Nebivolol-d4
(Rac)-Nebivolol-d4 ((Rac)-R 065824-d4) is a labelled racemic Nebivolol.
-
GC71283
(Rac)-Rotigotine
(Rac)-Rotigotine (N-0437) is a racemate of Rotigotine.
-
GC64905
(Rac)-Upacicalcet
(Rac)-Upacicalcet is the racemate of Upacicalcet.
-
GC71532
(rel)-Eglumegad
(rel)-Eglumegad ((rel)-LY354740) is a relative configuration of Eglumegad .
-
GC34367
(RS)-Butyryltimolol
(RS)-Butyryltimolol is the racemate of Butyryltimolol.
-
GC12279
(RS)-MCPG
alpha-MCPG
mGluR antagonist -
GC15292
(S)-(+)-Niguldipine hydrochloride
L-type Ca2+ channel blocker and α1A-adrenoceptor antagonist
-
GC12463
(S)-(-)-Atenolol
(S)-(-)-Atenolol is a potent β-adrenergic receptor blocker. (S)-(-)-Atenolol is the S(-) enantiomer of Atenolol, while the R(+) enantiomer of Atenolol has almost no β-receptor blocker activity.
-
GC15039
(S)-(-)-Pindolol
beta-adrenergic antagonist
-
GC16637
(S)-(-)-Propranolol hydrochloride
β-adrenoceptor antagonist
-
GC73666
(S)-Bexicaserin
(S)-Bexcaserin (compound 2) is a 5-HT2C receptor agonist with potential for studying obesity and psychiatric-related diseases.
-
GC60006
(S)-Carvedilol
(S)-Carvedilol, the S-enantiomer of Carvedilol, is a non-selective β/α-1 blocker.
-
GC71271
(S)-FTY720-phosphonate
FTY720 (S)-Phosphate is an agonist of S1P receptor 1 (S1PR1), used in the research of acute inflammatory diseases such as acute lung injury.
-
GC69904
(S)-JDQ-443
(S)-NVP-JDQ443
(S)-JDQ-443 is an isomer of JDQ-443. JDQ-443 is an orally effective and selective covalent KRAS G12C inhibitor. JDQ-443 has anti-tumor activity.