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GPCR/G protein

  1. Cat.No. Product Name Information
  2. GC68469 CID1231538 CID1231538  Chemical Structure
  3. GC68442 L-Glutamine-15N-1 L-Glutamine-15N-1  Chemical Structure
  4. GC68435 Clazosentan Clazosentan  Chemical Structure
  5. GC68424 Fingolimod-d4 hydrochloride Fingolimod-d4 hydrochloride  Chemical Structure
  6. GC68419 Prasugrel-d3 Prasugrel-d3  Chemical Structure
  7. GC68418 Clenbuterol-d9 Clenbuterol-d9  Chemical Structure
  8. GC68410 (S)-Mirtazapine-d3 (S)-Mirtazapine-d3  Chemical Structure
  9. GC68407 Phenylethanolamine A-d3 Phenylethanolamine A-d3  Chemical Structure
  10. GC68381 L-Glutamine-1-13C L-Glutamine-1-13C  Chemical Structure
  11. GC68364 Flibanserin-d4-1 Flibanserin-d4-1  Chemical Structure
  12. GC68349 Ifetroban sodium Ifetroban sodium  Chemical Structure
  13. GC68335 N-Demethyl MK-6884 N-Demethyl MK-6884  Chemical Structure
  14. GC68331 Ramelteon metabolite M-II-d3 Ramelteon metabolite M-II-d3  Chemical Structure
  15. GC68328 3-Hydroxy agomelatine-d3 3-Hydroxy agomelatine-d3  Chemical Structure
  16. GC68327 4-Hydroxyatomoxetine-d3 4-Hydroxyatomoxetine-d3  Chemical Structure
  17. GC68326 Ipratropium-d3 bromide Ipratropium-d3 bromide  Chemical Structure
  18. GC68320 Aprocitentan D4 Aprocitentan D4  Chemical Structure
  19. GC68316 Loteprednol Etabonate-d5 Loteprednol Etabonate-d5  Chemical Structure
  20. GC68210 (+)-Norfenfluramine (+)-Norfenfluramine  Chemical Structure
  21. GC68040 MSX-127 MSX-127  Chemical Structure
  22. GC68004 GDC-6036-NH GDC-6036-NH  Chemical Structure
  23. GC67989 (S)-Mirtazapine (S)-Mirtazapine  Chemical Structure
  24. GC67982 Treprostinil palmitil Treprostinil palmitil  Chemical Structure
  25. GC67979 MK-6884 MK-6884  Chemical Structure
  26. GC67977 Lubabegron Lubabegron  Chemical Structure
  27. GC67974 L-Glutamine-15N2 L-Glutamine-15N2  Chemical Structure
  28. GC67972 S-777469 S-777469  Chemical Structure
  29. GC67957 Orexin A (human, rat, mouse) (acetate) Orexin A (human, rat, mouse) (acetate)  Chemical Structure
  30. GC67937 (R)-Mirtazapine (R)-Mirtazapine  Chemical Structure
  31. GC67929 Orexin 2 Receptor Agonist 2 Orexin 2 Receptor Agonist 2  Chemical Structure
  32. GC67923 Renzapride Renzapride  Chemical Structure
  33. GC67897 CCR8 antagonist 2 CCR8 antagonist 2  Chemical Structure
  34. GC67893 Sigma-LIGAND-1 hydrochloride Sigma-LIGAND-1 hydrochloride  Chemical Structure
  35. GC67882 VU6028418 VU6028418  Chemical Structure
  36. GC67869 RPT193 RPT193  Chemical Structure
  37. GC67795 P2Y2R/GPR17 antagonist 1 P2Y2R/GPR17 antagonist 1  Chemical Structure
  38. GC67788 CCR6 antagonist 1 CCR6 antagonist 1  Chemical Structure
  39. GC67786 THX-B THX-B  Chemical Structure
  40. GC67768 TRV055 hydrochloride TRV055 hydrochloride  Chemical Structure
  41. GC67726 ONO-8711 dicyclohexylamine ONO-8711 dicyclohexylamine  Chemical Structure
  42. GC67715 Upidosin Upidosin  Chemical Structure
  43. GC67702 Abanoquil Abanoquil  Chemical Structure
  44. GC67692 Bufuralol Bufuralol  Chemical Structure
  45. GC67691 Midaglizole Midaglizole  Chemical Structure
  46. GC67683 Romifidine Romifidine  Chemical Structure
  47. GC67681 (αR,8aS)-GSK1614343 (αR,8aS)-GSK1614343  Chemical Structure
  48. GC67620 Methacholine bromide Methacholine (Acetyl-β-methylcholine) bromide is a potent muscarinic-3 (M3) agonist. Methacholine bromide acts directly on acetylcholine receptors on smooth muscle causing bronchoconstriction and airway narrowing. Methacholine bromide shows a high sensitivity to identify bronchial hyperresponsiveness (BHR). Methacholine bromide can be used to measure airway hyperresponsiveness (AHR) as a diagnostic aid in the assessment of individuals with asthma-like symptoms and normal resting expiratory flow rates. Methacholine bromide  Chemical Structure
  49. GC66678 2-(3-Trifluoromethylphenyl)glycine hydrochloride 2-(3-Trifluoromethylphenyl)glycine hydrochloride is a precursor of substituted 2-acetamido-5-aryl-l, 2,4-triazolones. Substituted 2-acetamido-5-aryl-l, 2,4-triazolones are dual V1a/V2 receptor antagonists and can be used in cardiovascular disease research. 2-(3-Trifluoromethylphenyl)glycine hydrochloride  Chemical Structure
  50. GC66645 L-Adenosine L-Adenosine is a metabolically stable enantiomeric analog and also is a potential probe. L-Adenosine has weakly inhibitory adenosine deaminase (ADA) activity with an Ki value of 385 μM. L-Adenosine can be used for the research of adenosine uptake and accumulation. L-Adenosine  Chemical Structure
  51. GC66473 ESI-08 ESI-08 is a potent and selective EPAC antagonist, which can completely inhibit both EPAC1 and EPAC2 (IC50 of 8.4 μM) activity. ESI-08 selectively blocks cAMP-induced EPAC activation, but does not inhibit cAMP-mediated PKA activation. ESI-08  Chemical Structure
  52. GC66468 Azilsartan mepixetil Azilsartan mepixetil is the antagonist of angiotensin II receptor. Azilsartan mepixetil has stronger and longer blood pressure effect, more abvious and longer lasting heart rate lowering effect and high safety. Azilsartan mepixetil achieves ideal protective effect for heart and kidney functions. Azilsartan mepixetil has the potential for the research of hypertension, chronic heart failure and diabetic nephropathy (extracted from patent CN107400122A). Azilsartan mepixetil  Chemical Structure
  53. GC66459 SLF1081851 SLF1081851 is a Spns2 inhibitor, inhibits S1P release (IC50=1.93 μM). SLF1081851 plays a key role in development and immune system. SLF1081851  Chemical Structure
  54. GC66440 Azilsartan mopivabil Azilsartan mopivabil is the potent antagonist of angiotensin II receptor. Azilsartan mopivabil  Chemical Structure
  55. GC66431 NCRW0005-F05 NCRW0005-F05 is a potent GPR139 agonist with an IC50 value of 0.21 μM. NCRW0005-F05 can be used to research diabetes, obesity and Parkinson's disease. NCRW0005-F05  Chemical Structure
  56. GC66413 RVD-Hpα TFA RVD-Hpα TFA is the N-terminally extended form of human hemopressin that acts as a selective CB1 receptor agonist. RVD-Hpα TFA increases intracellular Ca2+ levels in cells expressing CB1 receptors in vitro. RVD-Hpα TFA also high affinity CB2 positive allosteric modulator (Ki=50 nM). RVD-Hpα TFA  Chemical Structure
  57. GC66383 ACTH (11-24) (acetate) ACTH (11-24) (acetate) is an adrenocorticotropic hormone (ACTH) receptor antagonist. ACTH (11-24) is a fragment of adrenocorticotropic and induces cortisol release. ACTH (11-24) can be used for the research of central nervous system. ACTH (11-24) (acetate)  Chemical Structure
  58. GC66332 Eldelumab Eldelumab (BMS-936557) is a humanised anti-CXCL10 (IP-10) monoclonal antibody (IgG1 type). Eldelumab selectively binds to CXCL10 and blocks CXCL10-induced calcium flux and cell migration. Eldelumab can be used in studies of autoimmune and auto-inflammatory diseases such as rheumatoid arthritis, ulcerative colitis and crohn's disease. Eldelumab  Chemical Structure
  59. GC66088 α-Helical CRF(9-41) TFA α-Helical CRF(9-41) TFA is a competitive CRF2 receptor antagonist with KB of ~100 nM. α-Helical CRF(9-41) TFA is also a partial agonist of CRF1 receptor with an EC50 of 140 nM. α-Helical CRF(9-41) TFA  Chemical Structure
  60. GC66030 CB1 agonist 1 CB1 agonist 1 (compound 22) is an agonist of CB1. CB1 agonist 1 shows affinity to CB1 receptor with an pIC50 value of 5.7. CB1 agonist 1 can be used for the research of brain disorders. CB1 agonist 1  Chemical Structure
  61. GC66025 Angiotensin III, human, mouse TFA Angiotensin III, human, mouse (TFA) is an angiotensin. Angiotensin III, human, mouse TFA  Chemical Structure
  62. GC66020 ZINC69391 ZINC69391, a specific Rac1 inhibitor, interferes with Rac1-GEF interaction by masking Trp56 residue on Rac1 surface. ZINC69391 interferes with the interaction of Rac1 with Dock180 and reduces Rac1-GTP levels. ZINC69391 induces apoptosis, and shows antiproliferative and antimetastatic effects. ZINC69391  Chemical Structure
  63. GC66007 Adenosine receptor antagonist 3 Adenosine receptor antagonist 3 is a potent antagonist of adenosine receptor. Adenosine receptor antagonist 3 has the potential for the research of cancer disease (extracted from patent WO2019233994A1, compound 1). Adenosine receptor antagonist 3  Chemical Structure
  64. GC66001 RBC10 RBC10 is an anti-cancer agent. RBC10 inhibits the binding of Ral to its effector RALBP1. RBC10 also inhibits Ral-mediated cell spreading of murine embryonic fibroblasts and anchorage-independent growth of human cancer cell lines. RBC10  Chemical Structure
  65. GC65990 MLN3126 MLN3126 is an orally active and potent CCR9 antagonist. MLN3126 inhibits CCL25-induced calcium mobilization and chemotaxis of mouse primary thymocytes, wiht an IC50 value of 6.3 nM for calcium influx. MLN3126  Chemical Structure
  66. GC65987 EP3 antagonist 3 EP3 antagonist 3 (compound 2) is an orally active, potent and selective EP3 antagonist, with a pKi of 8.3. EP3 antagonist 3 shows excellent pharmacokinetic properties. EP3 antagonist 3 can be used for overactive bladder (OAB) research. EP3 antagonist 3  Chemical Structure
  67. GC65986 SAE-14 SAE-14 (compound SAE-14) is a potent, specific GPR183 antagonist with an IC50 value of 28.5 nM, can antagonize 7α, 25-OHC-induced calcium mobilization with IC50 value below 50 nM in HL-60 cells. GPR183 antagonist-1 can reverse allodynia in mice. SAE-14  Chemical Structure
  68. GC65983 5-HT3 antagonist 5 5-HT3 antagonist 5 is a quinoxalin-2-carboxamide compound, a 5-HT3 receptor antagonist. 5-HT3 antagonist 5 exerts antagonism on 5-HT3 agonist and 2-methyl-5-HT, and shows anti-depressant effect in mice. 5-HT3 antagonist 5  Chemical Structure
  69. GC65971 L-Glutamine-13C5 L-Glutamine-13C5 (L-Glutamic acid 5-amide-13C5) is the 13C-labeled L-Glutamine. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells. L-Glutamine-13C5  Chemical Structure
  70. GC65955 Denopamine Denopamine ((R)-(-)-Denopamine) is an orally active, selective β1-adrenergic agonist. Denopamine prolongs survival in a murine model of congestive heart failure induced by viral myocarditis: suppression of tumor necrosis factor-α production in the heart. Cardiovascular effects. Denopamine  Chemical Structure
  71. GC65946 VA-K-14 hydrochloride VA-K-14 hydrochloride is a specific thyroid-stimulating hormone receptor (TSHR) antagonist (IC50= 12.3 μM). VA-K-14 hydrochloride  Chemical Structure
  72. GC65910 SAR247799 SAR247799 (S1P1 agonist 3) is an oral activity, selective G-protein-biased sphingosine-1 phosphate receptor-1 (S1P1 ) agonist, with EC50s rang from 12.6 to 493 nM in S1P1-overexpressing cells and HUVECs. SAR247799 can be used for the research of endothelial protection, including type-2 diabetes, metabolic syndrome. SAR247799  Chemical Structure
  73. GC65908 CXCR2 antagonist 2 CXCR2 antagonist 2 is a potent CXCR2 antagonist for cancer immunotherapy with an IC50 value of 95 nM. CXCR2 antagonist 2  Chemical Structure
  74. GC65904 KRAS G12C inhibitor 28 KRAS G12C inhibitor 28 is a KRAS G12C inhibitor with an IC50 of 57 nM. KRAS G12C inhibitor 28 has antitumor effects (WO2021113595A1; Example 1). KRAS G12C inhibitor 28  Chemical Structure
  75. GC65901 Adenosine receptor antagonist 2 Adenosine receptor antagonist 2 is an orally active A2a/A2b adenosine receptor antagonist with IC50s of 1 nM and 3 nM, respectively. Adenosine receptor antagonist 2 has anti-tumor activity. Adenosine receptor antagonist 2  Chemical Structure
  76. GC65893 Tildacerfont Tildacerfont is a potent and orally active corticotrophin-releasing factor type 1 (CRF1) receptort antagonis. Tildacerfont effectively reduces adrenocorticotropic hormone (ACTH) and adrenal androgen levels. Tildacerfont has favourable safety profile. Tildacerfont can be used for researching congenital adrenal hyperplasia. Tildacerfont  Chemical Structure
  77. GC65874 Medroxalol Medroxalol (RMI81968) is an orally active adrenergic receptor antagonist, blocks α- and β-adrenergic receptors. Medroxalol shows antihypertensive and vasodilating effects. Medroxalol  Chemical Structure
  78. GC65873 SOS1-IN-14 SOS1-IN-14 is a potent, selective and orally active SOS1 inhibitor with an IC50 value of 3.9 nM. SOS1-IN-14 can be absorbed in the intestine via a P-glycoprotein-mediated efflux mechanism. SOS1-IN-14 can be used to research KRAS-mutated cancers. SOS1-IN-14 has better potent tumor suppression than BI-3406 (HY-125817). SOS1-IN-14  Chemical Structure
  79. GC65614 Ticlopidine hydrochloride Ticlopidine hydrochloride is an adenosine diphosphate (ADP) receptor inhibitor against platelet aggregation with IC50 of ~2 μM. Ticlopidine hydrochloride  Chemical Structure
  80. GC65579 ONO-0300302 ONO-0300302 is an orally active and potent LPA1 (lysophosphatidic acid receptor 1) antagonist, with an IC50 of 0.086 μM. ONO-0300302  Chemical Structure
  81. GC65568 5-HT2B antagonist-1 5-HT2B antagonist-1 is an orally active 5-HT2B receptor antagonist with an IC50 value of 33.4 nM. 5-HT2B antagonist-1  Chemical Structure
  82. GC65567 M4 mAChR agonist-1 M4 mAChR agonist-1 (compound 10a) is a potent M4 mAChR agonist with an EC50 >10 μM for human M4. M4 mAChR agonist-1  Chemical Structure
  83. GC65565 Cyproheptadine Cyproheptadine is a potent and orally active 5-HT2A receptor antagonist, with antidepressant and antiserotonergic effects. Cyproheptadine  Chemical Structure
  84. GC65550 Danavorexton Danavorexton is an orexin receptor agonist. Danavorexton  Chemical Structure
  85. GC65504 L-Hyoscyamine-d3 L-Hyoscyamine-d3  Chemical Structure
  86. GC65480 ARS-1323-alkyne ARS-1323-alkyne, a switch-II pocket (S-IIP) inhibitor, is a conformational specific chemical reporter of KRASG12C nucleotide state in living cells. ARS-1323-alkyne  Chemical Structure
  87. GC65476 CXCR7 antagonist-1 hydrochloride CXCR7 antagonist-1 hydrochloride is a CXCR7 antagonist that inhibits the binding of the SDF-1 chemokine (also known as the CXCL12 chemokine) or I-TAC (also known as CXCL11) to the chemokine receptor CXCR7. CXCR7 antagonist-1 hydrochloride  Chemical Structure
  88. GC65450 CT1812 CT1812 (Sigma-2 receptor antagonist 1) is a sigma-2 (σ-2) receptor antagonist. CT1812  Chemical Structure
  89. GC65415 Felypressin acetate Felypressin acetate (PLV-2 acetate) is a non-catecholamine vasoconstrictor and a vasopressin 1 agonist. Felypressin acetate  Chemical Structure
  90. GC65389 Auglurant Auglurant (VU0424238) is a novel and selective mGlu5 antagonist with an IC50 value of 11 nM (rat) and an IC50 value of 14 nM (human). Auglurant  Chemical Structure
  91. GC65382 Orexin receptor antagonist 5 Orexin receptor antagonist 5  Chemical Structure
  92. GC65379 Guvacoline hydrochloride Guvacoline hydrochloride, a pyridine alkaloid found in Areca triandra, can act as a weak full agonist of atrial and ileal muscarinic receptors. Guvacoline hydrochloride  Chemical Structure
  93. GC65370 ORIC-101 ORIC-101 is a highly potent and selective glucocorticoid receptor antagonist, with an EC50 of 5.6 nM. ORIC-101  Chemical Structure
  94. GC65345 BI 653048 BI 653048 is a selective and orally active nonsteroidal?glucocorticoid (GC)?agonist with an IC50 value of 55 nM. BI 653048  Chemical Structure
  95. GC65324 RP101988 RP101988, the major active metabolite of Ozanimod, is a selective, potent S1PR1 (sphingosine-1-phosphate receptor 1) agonist, with EC50s of 0.19 nM and 32.8 nM for S1PR1 and S1PR5, respectivlely. RP101988  Chemical Structure
  96. GC65317 EP2 receptor antagonist-1 EP2 receptor antagonist-1 (compound 1) is a potent, reversible, and agonist dependent allosteric prostaglandin EP2 receptor antagonist. EP2 receptor antagonist-1  Chemical Structure
  97. GC65313 SSTR5 antagonist 1 SSTR5 antagonist 1 is a potent, selective, and orally available somatostatin receptor subtype 5 (SSTR5) antagonist with IC50s of 9.6 and 57 nM for hSSTR5 and mSSTR5, respectively. SSTR5 antagonist 1  Chemical Structure
  98. GC65296 Pimethixene maleate Pimethixene maleate is antihistamine and antiserotonergic compound, acts as an antimigraine agent. Pimethixene maleate  Chemical Structure
  99. GC65277 Tedalinab Tedalinab (GRC-10693) is a potent, orally active, and selective cannabinoid receptor 2 (CB2) agonist. Tedalinab  Chemical Structure
  100. GC65276 Tasipimidine sulfate Tasipimidine sulfate is an orally active and selective α2A-adrenoceptor agonist with a pEC50 of 7.57 against human α2A-adrenoceptor. Tasipimidine sulfate  Chemical Structure
  101. GC65270 Digeranyl bisphosphonate Digeranyl bisphosphonate (DGBP) is a potent geranylgeranylpyrophosphate (GGPP) synthase inhibitor, which inhibits geranylgeranylation of Rac1. Digeranyl bisphosphonate  Chemical Structure

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