GPCR/G protein
- Neuropeptide FF/AF Receptors(43)
- Neuropeptide S Receptor(1)
- GPBA Receptor(1)
- Trace Amine 1 Receptor(2)
- GPCR protein(1)
- FFAR3(1)
- Formyl Peptide Receptors(11)
- 5-HT Receptor(415)
- Acetylcholine(19)
- Adenosine Deaminase(12)
- Adenosine Receptor(133)
- Adenosine Kinase(5)
- Adiponectin Receptor(4)
- Adrenergic Receptor(404)
- Adrenergic Transporters(5)
- Apelin Receptor(9)
- Angiotensin Receptor(110)
- Bombesin Receptors(22)
- Bradykinin Receptors(27)
- Calcitonin and Related Receptors(10)
- Cannabinoid Receptor(137)
- Calcimimetic Agent(3)
- CaSR(24)
- CCK1 Receptors(7)
- CCK2 Receptors(7)
- CCR(79)
- Chemokine Receptors(25)
- CRF1 Receptors(9)
- CRF2 Receptors(3)
- CXCR(82)
- CysLT1 receptor(1)
- Endothelin Receptor(50)
- EP1 Receptor(3)
- EP4 Receptor(5)
- ERRγ(2)
- ETA Receptors(5)
- ETB Receptors(5)
- Free Fatty Acid Receptors(20)
- Galanin Receptors(11)
- Ghrelin Receptors(12)
- GHSR(22)
- GIP Receptor(5)
- Glucagon Receptor(66)
- Glucocorticoid Receptor(87)
- GLUT1(2)
- Gonadotropin-Releasing Hormone Receptors(3)
- GPCR19(13)
- GPR109A(4)
- GPR119(11)
- GPR120(12)
- GPR35(8)
- GPR44(1)
- GPR55(10)
- Hydroxycarboxylic Acid Receptors(5)
- Leukotriene Receptor(55)
- LPA Receptor(15)
- LPL Receptor(60)
- LTD4 Receptor(2)
- mGluR (115)
- Melanin-concentrating Hormone Receptors(7)
- Melanocortin (MC) Receptors(49)
- Melatonin Receptors(23)
- Motilin Receptor(7)
- MT Receptor(1)
- Non-selective CRF(7)
- Neurotensin Receptors(21)
- NK2 Receptors(7)
- NK3 Receptor(8)
- NOP Receptor(22)
- NPY Receptors(28)
- Orexin(3)
- Orphan 7-TM Receptors(6)
- OX Receptor(42)
- Oxytocin Receptors(21)
- P2Y Receptor(55)
- PACAP Receptors(3)
- PAF Receptors(8)
- Peptide Receptors(15)
- PGD2 Receptor(2)
- Prostaglandin Receptor(168)
- Prostanoid Receptors(25)
- Protease-Activated Receptors(10)
- RGS(4)
- S1P receptor(9)
- Secretin Receptors(1)
- Sensory Neuron-Specific Receptors(1)
- Somatostatin Receptor(34)
- Sigma Receptor(54)
- Vasopressin Receptor(33)
- 17,20-lyase(7)
- Ras(118)
- Urotensin-II Receptor(11)
- VIP Receptors(7)
- EBI2/GPR183(5)
- TSH Receptor(10)
- NK Receptor(1)
- GPR81(1)
- C3aR(1)
- CysLT2 receptor(1)
- S1P receptor inhibitor(22)
- CCKB(1)
- FFAR1 (GPR40)(22)
- GPR84(5)
- Neuromedin U Receptors(2)
- Kisspeptin Receptor(4)
- CRFR(21)
- RGS Protein(7)
- Urotensin Receptor(6)
- Cholecystokinin Receptor(23)
- GPR139(3)
- mAChR(179)
- MCHR1 (GPR24)(16)
- Neurokinin Receptor(72)
- cGMP(18)
- GRK(1)
Products for GPCR/G protein
- Cat.No. Product Name Information
-
GC66088
α-Helical CRF(9-41) TFA
α-Helical CRF(9-41) TFA is a competitive CRF2 receptor antagonist with KB of ~100 nM. α-Helical CRF(9-41) TFA is also a partial agonist of CRF1 receptor with an EC50 of 140 nM.
-
GC64563
α-Methylserotonin
-
GC38007
β-Melanocyte Stimulating Hormone (MSH), human TFA
-
GC37983
β3-AR agonist 1
β3-AR agonist 1 (compound 15) is a highly potent, selective, and orally available β3-adrenergic receptor (β3-AR) agonist (EC50=18 nM), being inactive to β1-, β2-, and α1A-AR (β1/β3, β2/β3, and α1A/β3>556-fold).
-
GC40105
βARK1 Inhibitor
βARK1 Inhibitor (methyl 5-[2-(5-nitro-2-furyl)vinyl]-2-furoate) is a GRK2 (β-ARK1) inhibitor.
-
GC61462
γ-1-Melanocyte Stimulating Hormone (MSH), amide
-
GC17002
γ1-MSH
γ1-MSH is a melanocortin MC3 receptor agonist, with a Ki of 34 nM for the rat MC3 receptor.
-
GC62708
σ1 Receptor antagonist-1
σ1 Receptor antagonist-1 is a highly potent and selective sigma 1 receptor antagonist (pKi=10.28).
-
GC15519
α-CGRP (human)
Endogenous calcitonin gene-related peptide receptor (CGRP) agonist
-
GC11346
α-helical CRF 9-41
Antagonist of corticotropin releasing factor receptor
-
GC11577
α-Methyl-5-hydroxytryptamine maleate
5-HT2B receptor agonist
-
GC31237
α1 adrenoceptor-MO-1
α1 adrenoceptor-MO-1, an S enantiomer, has affinity at alpha 1 adrenergic receptor, shows alphalytic activity, and possesses analgesic action; more active than R enantiomer.
-
GC33693
β-Melanocyte Stimulating Hormone (MSH), human (Beta-MSH (1-22) (human))
β-Melanocyte Stimulating Hormone (MSH), human (Beta-MSH (1-22) (human)), a 22-residue peptide, acts as an endogenous melanocortin-4 receptor (MC4-R) agonist.
-
GC31573
β3-AR agonist 2
β3-AR agonist 2 is a potent and selective β3-adrenergic receptor (β3-AR) agonist with an EC50 of 8 nM.
-
GC34231
γ-1-Melanocyte Stimulating Hormone (MSH), amide
-
GC17413
(±)-5'-Chloro-5'-deoxy-ENBA
adenosine A1 receptor agonist, selective and high-affinity
-
GC17408
(±)-AC 7954 hydrochloride
urotensin-II (UT) receptor agonist
-
GC15045
(±)-AMG 487
CXCR3 antagonist
-
GC41668
(±)-Clopidogrel (hydrochloride)
Clopidogrel is an antithrombic compound whose active metabolite is a selective, irreversible antagonist of the platelet purinergic P2Y12 receptor (IC50 = 100 nM).
-
GC16838
(±)-Cloprostenol sodium salt
prostaglandin F2α (PGF2α) analog,FP receptor agonist
-
GC46283
(±)-Clorprenaline-d7
A neuropeptide with diverse biological activities
-
GC18090
(±)-J 113397
NOP receptor antagonist
-
GC62727
(±)-Penbutolol-d9 hydrochloride
(±)-Penbutolol-d9 ((Rac)-Penbutolol-d9) hydrochloride is a deuterium labeled (±)-Penbutolol hydrochloride.
-
GC15144
(±)-PPCC oxalate
sigma (σ) receptor ligand
-
GC10907
(±)-SLV 319
(±)-SLV 319 ((±)-SLV319) is the racemate of SLV319.
-
GC12394
(±)-trans-ACPD
metabotropic glutamate receptors agonist
-
GC67681
(αR,8aS)-GSK1614343
-
GC32523
(±)-Befunolol
(±)-Befunolol is a β-adrenoceptor blocking agent.
-
GC34957
(+)-Cevimeline hydrochloride hemihydrate
(+)-Cevimeline hydrochloride hemihydrate ((+)-SNI-2011), a potent muscarinic receptor agonist, is a candidate therapeutic drug for xerostomia in Sjogren's syndrome.
-
GC30743
(+)-Cloprostenol (D-Cloprostenol)
(+)-Cloprostenol (D-Cloprostenol) is a prostaglandin F2α (PGF2α) analogue, and shows selective agonistic activity at the prostaglandin receptor.
-
GC45259
(+)-Cloprostenol (sodium salt)
(+)-Cloprostenol (sodium salt) is a more water soluble, crystalline form of (+)-cloprostenol.
-
GC12750
(+)-Fluprostenol
Prostaglandin F2α (FP) receptor agonist
-
GC18146
(+)-Igmesine hydrochloride
σ1 receptor ligand
-
GC68210
(+)-Norfenfluramine
-
GC31597
(+)-Penbutolol ((R)-Penbutolol)
(+)-Penbutolol ((R)-Penbutolol) is a β-adrenoceptor antagonist, with an IC50 of 0.74 μM.
-
GC17301
(+)-SK&F 10047 hydrochloride
prototypical σ1 receptor agonist
-
GC10675
(+,-)-Octopamine HCl
Octopamine ((±)-p-Octopamine) hydrochloride, a biogenic monoamine structurally related to noradrenaline, acts as a neurohormone, a neuromodulator and a neurotransmitter in invertebrates.
-
GC50245
(+/-)-ADX 71743
Negative allosteric modulator of mGlu7 receptors; brain penetrant
-
GC50048
(+/-)-PPCC oxalate
Selective sigma (σ) agonist (σ1> σ2)
-
GC61646
(-)-Camphoric acid
-
GC16919
(1R,1'S,3'R/1R,1'R,3'S)-L-054,264
somatostatin sst2 receptor agonist
-
GC34963
(1R,2S)-VU0155041
(1R,2S)-VU0155041, Cis regioisomer of VU0155041, is a partial mGluR4 agonist with an EC50 of 2.35 μM.
-
GC34965
(20S)-Protopanaxatriol
An active ginsenoside metabolite
-
GC38712
(2R,3R)-E1R
(2R,3R)-E1R (Compound 2b) is an enantiomer of E1R.
-
GC38713
(2R,3S)-E1R
(2R,3S)-E1R (Compound 2c) is an enantiomer of E1R.
-
GC38714
(2S,3S)-E1R
(2S,3S)-E1R (Compound 2d) is an enantiomer of E1R.
-
GC32644
(4E)-SUN9221
(4E)-SUN9221 is a potent antagonist of α1-adrenergic receptor and 5-HT2 receptor, with antihypertensive and anti-platelet aggregation activities.
-
GA20063
(D-Ala²)-Gastric Inhibitory Polypeptide (human)
GIP receptor agonist.
-
GA20084
(Deamino-Cys¹,β-cyclohexyl-Ala⁴,Arg⁸)-Vasopressin
Studies revealed that this specific vasopressin agonist exhibited a nanomolar affinity for V-1b receptors from various mammalian species (bovine, human, rat). It exhibited high V-1b/V-1a and V-1b/oxytocin selectivity for rat, human, and bovine receptors. Furthermore, it showed a high V-1b/V-2 specificity for both bovine and human vasopressin receptors. Therefore, d(Cha?)-AVP is a promising tool for research of V-1b receptor structure-function relationships.
-
GC64657
(E/Z)-ZINC09659342
(E/Z)-ZINC09659342 is an inhibitor of Lbc-RhoA interaction.
-
GA20195
(Gly¹,Ser³·²²,Gln⁴·³⁴,Thr⁶,Arg¹⁹,Tyr²¹,Ala²³·³¹,Aib³²)-Pancreatic Polypeptide (human)
(Gly¹,Ser³.²²,Gln⁴.³⁴,Thr⁶,Arg¹⁹,Tyr²¹,Ala²³.³¹,Aib³²)-Pancreatic Polypeptide (human) is a potent and selective neuropeptide Y Y5 receptor agonist with an IC50 of 0.24 nM for binding to the hY5 receptor.
-
GA20221
(Hyp³)-Bradykinin
(Hyp³)-Bradykinin, naturally occurring peptide hormone, is a bradykinin receptor agonist.
-
GA20229
(Leu³¹,Pro³⁴)-Neuropeptide Y (human, rat)
(Leu³¹,Pro³⁴)-Neuropeptide Y (human, rat) is a specific neuropeptide Y Y1 receptor agonist.
-
GC11952
(R)-(+)-Atenolol
less active enantiomer of the racemic β1-adrenergic receptor antagonist, (R,S)-atenolol.
-
GC11937
(R)-(+)-m-Nitrobiphenyline oxalate
α2C-AR (adrenoceptor) agonist
-
GC10608
(R)-(+)-Propranolol hydrochloride
β-adrenoceptor antagonist
-
GC11219
(R)-(+)-Tolterodine
(R)-(+)-Tolterodine(PNU-200583) is a potent muscarinic receptor antagonists that show selectivity for the urinary bladder over salivary glands in vivo.
-
GC12144
(R)-(-)-Niguldipine hydrochloride
L-type Ca2+ channel blocker and α1A-adrenoceptor antagonist
-
GC34985
(R)-ADX-47273
(R)-ADX-47273 is a potent mGluR5 positive allosteric modulator, with an EC50 of 168 nM for potentiation .
-
GC60001
(R)-Carvedilol
(R)-Carvedilol ((R)-BM 14190), the R-enantiomer of Carvedilol, is a non-selective β/α-1 blocker.
-
GC69805
(R)-Casopitant
(R)-Casopitant ((R)-GW679769) is an isomer of Casopitant. Casopitant is an NK(1) receptor antagonist that can be used in the research of chemotherapy-induced nausea and vomiting.
-
GC67937
(R)-Mirtazapine
-
GC10028
(R)-SLV 319
CB1 receptor antagonist
-
GC39298
(R)-Terazosin
(R)-Terazosin is an active R-enantiomer of Terazosin.
-
GC50426
(R)-ZINC 3573
MRGPRX2 agonist
-
GC62588
(R,R)-CXCR2-IN-2
(R,R)-CXCR2-IN-2, diastereoisomer of CXCR2-IN-2 (compound 68), is a brain penetrant CXCR2 antagonist with a pIC50 of 9 and 6.8 in the Tango assay and d in the HWB Gro-α induced CD11b expression assay, respectively.
-
GC14145
(R,R)-Formoterol
β2-selective adrenergic agonist
-
GC34995
(R,R)-Palonosetron Hydrochloride
(R,R)-Palonosetron Hydrochloride is the active enantiomer of Palonosetron.
-
GC12823
(R,S)-Atenolol
(R,S)-Atenolol ((RS)-(R,S)-Atenolol) is a cardioselective β1-adrenergic receptor blocker, with a Ki of 697 nM atβ1-adrenoceptor in guine pig left ventricle membrane.
-
GC63452
(Rac)-5-Hydroxymethyl Tolterodine
(Rac)-5-Hydroxymethyl Tolterodine ((Rac)-Desfesoterodine), an active metabolite of Tolterodine, is a mAChR antagonist (Ki values of 2.3 nM, 2 nM, 2.5 nM, 2.8 nM, and 2.9 nM for M1, M2, M3, M4, and M5 receptors, respectively).
-
GC19541
(rac)-Antineoplaston A10
(rac)-Antineoplaston A10 is the racemate of Antineoplaston A10
-
GC64481
(rac)-Dobutamine-d4 hydrochloride
-
GC62642
(rac)-Dobutamine-d6 hydrochloride
-
GC38721
(Rac)-E1R
(Rac)-E1R (Compound 2) is the racemate of E1R.
-
GC63410
(Rac)-MRI-1867
(Rac)-MRI-1867 ((Rac)-MRI-1867, compound 6b) is a cannabinoid receptor type 1 (CB1R)/iNOS antagonist, with a Ki of 5.7 nM for CB1R.
-
GC62228
(rac)-Nebivolol-d4
(Rac)-Nebivolol-d4 ((Rac)-R 065824-d4) is a labelled racemic Nebivolol.
-
GC64905
(Rac)-Upacicalcet
(Rac)-Upacicalcet is the racemate of Upacicalcet.
-
GC34367
(RS)-Butyryltimolol
(RS)-Butyryltimolol is the racemate of Butyryltimolol.
-
GC12279
(RS)-MCPG
mGluR antagonist
-
GC15292
(S)-(+)-Niguldipine hydrochloride
L-type Ca2+ channel blocker and α1A-adrenoceptor antagonist
-
GC12463
(S)-(-)-Atenolol
β-adrenergic blocker
-
GC15039
(S)-(-)-Pindolol
beta-adrenergic antagonist
-
GC16637
(S)-(-)-Propranolol hydrochloride
β-adrenoceptor antagonist
-
GC60006
(S)-Carvedilol
(S)-Carvedilol, the S-enantiomer of Carvedilol, is a non-selective β/α-1 blocker.
-
GC69904
(S)-JDQ-443
(S)-JDQ-443 is an isomer of JDQ-443. JDQ-443 is an orally effective and selective covalent KRAS G12C inhibitor. JDQ-443 has anti-tumor activity.
-
GC35002
(S)-Mapracorat
(S)-Mapracorat is a selective and less active glucocorticoid receptor agonist.
-
GC16349
(S)-MCPG
mGluR antagonist
-
GC67989
(S)-Mirtazapine
-
GC68410
(S)-Mirtazapine-d3
-
GC69941
(S)-Renzapride
(S)-Renzapride ((S)-BRL 24924) is an isomer of Renzapride. Renzapride is a 5-HT4 receptor agonist with a Ki value of 115 nM. It also acts as an antagonist for the 5HT2b and 5HT3 receptors. Renzapride can be used in research on constipation-predominant irritable bowel syndrome (C-IBS).
-
GC10753
(S)-SLV 319
(S)-SLV 319 (SLV319) is a potent, selective and orally active antagonist of cannabinoid CB1 receptor, with a Ki of 7.8 nM.
-
GC39249
(S)-Terazosin
(S)-Terazosin is an active S-enantiomer of Terazosin.
-
GC69977
(S)-Veliflapon
(S)-Veliflapon ((S)-BAY X 1005) is an orally active leukotriene biosynthesis and 5-lipoxygenase activating protein (FLAP) inhibitor. It inhibits the formation of leukotriene B4 (LTB4) in rat, mouse, and human white blood cells with IC50 values of 0.026 μM, 0.039 μM, and 0.22 μM respectively. (S)-Veliflapon exhibits enantioselectivity in human whole blood.
-
GC60425
(S)-Verapamil D7 hydrochloride
(S)-Verapamil D7 hydrochloride ((S)-(-)-Verapamil D7 hydrochloride) is a deuterium labeled (S)-Verapamil hydrochloride. (S)-Verapamil hydrochloride (S(-)-Verapamil hydrochloride) inhibits leukotriene C4 (LTC4) and calcein transport by MRP1. (S)-Verapamil hydrochloride leads to the death of potentially resistant tumor cells.
-
GC60008
(S)-Verapamil hydrochloride
(S)-Verapamil hydrochloride (S(-)-Verapamil hydrochloride) inhibits leukotriene C4 (LTC4) and calcein transport by MRP1. (S)-Verapamil hydrochloride leads to the death of potentially resistant tumor cells.
-
GA20291
(Sar¹)-Angiotensin II
(Sar¹)-Angiotensin II, an analogue of Angiotensin II, is a specific agonist of angiotensin AT1 receptor.
-
GC35011
(Z)-Thiothixene
(Z)-Thiothixene is an antagonist of serotonergic receptor extracted from patent US 20150141345 A1.
-
GC16663
(±)-4-hydroxy Propranolol (hydrochloride)
β1- and β2-adrenergic receptors inhibitor
-
GC15087
(±)-Talinolol
β1-selective adrenoceptor antagonist
-
GC15528
(±)trans-2,5-bis-(3,4,5-Trimethoxyphenyl)-1,3-dioxolane
PAF receptor antagonist