GPCR/G protein
- Neuropeptide FF/AF Receptors(40)
- Neuropeptide S Receptor(1)
- GPBA Receptor(1)
- Trace Amine 1 Receptor(2)
- GPCR protein(1)
- FFAR3(1)
- Formyl Peptide Receptors(11)
- 5-HT Receptor(385)
- Acetylcholine(19)
- Adenosine Deaminase(10)
- Adenosine Receptor(121)
- Adenosine Kinase(4)
- Adiponectin Receptor(3)
- Adrenergic Receptor(365)
- Adrenergic Transporters(5)
- Apelin Receptor(9)
- Angiotensin Receptor(98)
- Bombesin Receptors(22)
- Bradykinin Receptors(26)
- Calcitonin and Related Receptors(10)
- Cannabinoid Receptor(96)
- Calcimimetic Agent(2)
- CaSR(19)
- CCK1 Receptors(7)
- CCK2 Receptors(7)
- CCR(65)
- Chemokine Receptors(25)
- CRF1 Receptors(9)
- CRF2 Receptors(3)
- CXCR(64)
- CysLT1 receptor(1)
- Endothelin Receptor(46)
- EP1 Receptor(2)
- EP4 Receptor(2)
- ERRγ(1)
- ETA Receptors(5)
- ETB Receptors(5)
- Free Fatty Acid Receptors(16)
- Galanin Receptors(11)
- Ghrelin Receptors(11)
- GHSR(18)
- GIP Receptor(5)
- Glucagon Receptor(57)
- Glucocorticoid Receptor(78)
- GLUT1(1)
- Gonadotropin-Releasing Hormone Receptors(3)
- GPCR19(12)
- GPR109A(3)
- GPR119(10)
- GPR120(9)
- GPR35(8)
- GPR44(1)
- GPR55(8)
- Hydroxycarboxylic Acid Receptors(5)
- Leukotriene Receptor(54)
- LPA Receptor(12)
- LPL Receptor(54)
- mGluR (102)
- Melanin-concentrating Hormone Receptors(7)
- Melanocortin (MC) Receptors(43)
- Melatonin Receptors(22)
- Motilin Receptor(6)
- MT Receptor(1)
- Non-selective CRF(7)
- Neurotensin Receptors(17)
- NK2 Receptors(7)
- NK3 Receptor(5)
- NOP Receptor(20)
- NPY Receptors(25)
- Orexin(3)
- Orphan 7-TM Receptors(6)
- OX Receptor(38)
- Oxytocin Receptors(20)
- P2Y Receptor(52)
- PACAP Receptors(3)
- PAF Receptors(7)
- Peptide Receptors(15)
- PGD2 Receptor(1)
- Prostaglandin Receptor(157)
- Prostanoid Receptors(25)
- Protease-Activated Receptors(10)
- RGS(2)
- S1P receptor(8)
- Secretin Receptors(1)
- Sensory Neuron-Specific Receptors(1)
- Somatostatin Receptor(32)
- Sigma Receptor(52)
- Vasopressin Receptor(29)
- 17,20-lyase(4)
- Ras(101)
- Urotensin-II Receptor(11)
- VIP Receptors(6)
- EBI2/GPR183(5)
- TSH Receptor(9)
- NK Receptor(1)
- GPR81(1)
- C3aR(1)
- CysLT2 receptor(1)
- S1P receptor inhibitor(22)
- CCKB(1)
- FFAR1 (GPR40)(20)
- GPR84(4)
- Neuromedin U Receptors(2)
- Kisspeptin Receptor(4)
- CRFR(21)
- RGS Protein(5)
- Urotensin Receptor(6)
- Cholecystokinin Receptor(23)
- GPR139(2)
- mAChR(167)
- MCHR1 (GPR24)(16)
- Neurokinin Receptor(66)
- cGMP(18)
- GRK(1)
- Cat.No. Product Name Information
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GC68469
CID1231538
-
GC68442
L-Glutamine-15N-1
-
GC68435
Clazosentan
-
GC68424
Fingolimod-d4 hydrochloride
-
GC68419
Prasugrel-d3
-
GC68418
Clenbuterol-d9
-
GC68410
(S)-Mirtazapine-d3
-
GC68407
Phenylethanolamine A-d3
-
GC68381
L-Glutamine-1-13C
-
GC68364
Flibanserin-d4-1
-
GC68349
Ifetroban sodium
-
GC68335
N-Demethyl MK-6884
-
GC68331
Ramelteon metabolite M-II-d3
-
GC68328
3-Hydroxy agomelatine-d3
-
GC68327
4-Hydroxyatomoxetine-d3
-
GC68326
Ipratropium-d3 bromide
-
GC68320
Aprocitentan D4
-
GC68316
Loteprednol Etabonate-d5
-
GC68210
(+)-Norfenfluramine
-
GC68040
MSX-127
-
GC68004
GDC-6036-NH
-
GC67989
(S)-Mirtazapine
-
GC67982
Treprostinil palmitil
-
GC67979
MK-6884
-
GC67977
Lubabegron
-
GC67974
L-Glutamine-15N2
-
GC67972
S-777469
-
GC67957
Orexin A (human, rat, mouse) (acetate)
-
GC67937
(R)-Mirtazapine
-
GC67929
Orexin 2 Receptor Agonist 2
-
GC67923
Renzapride
-
GC67897
CCR8 antagonist 2
-
GC67893
Sigma-LIGAND-1 hydrochloride
-
GC67882
VU6028418
-
GC67869
RPT193
-
GC67795
P2Y2R/GPR17 antagonist 1
-
GC67788
CCR6 antagonist 1
-
GC67786
THX-B
-
GC67768
TRV055 hydrochloride
-
GC67726
ONO-8711 dicyclohexylamine
-
GC67715
Upidosin
-
GC67702
Abanoquil
-
GC67692
Bufuralol
-
GC67691
Midaglizole
-
GC67683
Romifidine
-
GC67681
(αR,8aS)-GSK1614343
-
GC67620
Methacholine bromide
Methacholine (Acetyl-β-methylcholine) bromide is a potent muscarinic-3 (M3) agonist. Methacholine bromide acts directly on acetylcholine receptors on smooth muscle causing bronchoconstriction and airway narrowing. Methacholine bromide shows a high sensitivity to identify bronchial hyperresponsiveness (BHR). Methacholine bromide can be used to measure airway hyperresponsiveness (AHR) as a diagnostic aid in the assessment of individuals with asthma-like symptoms and normal resting expiratory flow rates.
-
GC66678
2-(3-Trifluoromethylphenyl)glycine hydrochloride
2-(3-Trifluoromethylphenyl)glycine hydrochloride is a precursor of substituted 2-acetamido-5-aryl-l, 2,4-triazolones. Substituted 2-acetamido-5-aryl-l, 2,4-triazolones are dual V1a/V2 receptor antagonists and can be used in cardiovascular disease research.
-
GC66645
L-Adenosine
L-Adenosine is a metabolically stable enantiomeric analog and also is a potential probe. L-Adenosine has weakly inhibitory adenosine deaminase (ADA) activity with an Ki value of 385 μM. L-Adenosine can be used for the research of adenosine uptake and accumulation.
-
GC66473
ESI-08
ESI-08 is a potent and selective EPAC antagonist, which can completely inhibit both EPAC1 and EPAC2 (IC50 of 8.4 μM) activity. ESI-08 selectively blocks cAMP-induced EPAC activation, but does not inhibit cAMP-mediated PKA activation.
-
GC66468
Azilsartan mepixetil
Azilsartan mepixetil is the antagonist of angiotensin II receptor. Azilsartan mepixetil has stronger and longer blood pressure effect, more abvious and longer lasting heart rate lowering effect and high safety. Azilsartan mepixetil achieves ideal protective effect for heart and kidney functions. Azilsartan mepixetil has the potential for the research of hypertension, chronic heart failure and diabetic nephropathy (extracted from patent CN107400122A).
-
GC66459
SLF1081851
SLF1081851 is a Spns2 inhibitor, inhibits S1P release (IC50=1.93 μM). SLF1081851 plays a key role in development and immune system.
-
GC66440
Azilsartan mopivabil
Azilsartan mopivabil is the potent antagonist of angiotensin II receptor.
-
GC66431
NCRW0005-F05
NCRW0005-F05 is a potent GPR139 agonist with an IC50 value of 0.21 μM. NCRW0005-F05 can be used to research diabetes, obesity and Parkinson's disease.
-
GC66413
RVD-Hpα TFA
RVD-Hpα TFA is the N-terminally extended form of human hemopressin that acts as a selective CB1 receptor agonist. RVD-Hpα TFA increases intracellular Ca2+ levels in cells expressing CB1 receptors in vitro. RVD-Hpα TFA also high affinity CB2 positive allosteric modulator (Ki=50 nM).
-
GC66383
ACTH (11-24) (acetate)
ACTH (11-24) (acetate) is an adrenocorticotropic hormone (ACTH) receptor antagonist. ACTH (11-24) is a fragment of adrenocorticotropic and induces cortisol release. ACTH (11-24) can be used for the research of central nervous system.
-
GC66332
Eldelumab
Eldelumab (BMS-936557) is a humanised anti-CXCL10 (IP-10) monoclonal antibody (IgG1 type). Eldelumab selectively binds to CXCL10 and blocks CXCL10-induced calcium flux and cell migration. Eldelumab can be used in studies of autoimmune and auto-inflammatory diseases such as rheumatoid arthritis, ulcerative colitis and crohn's disease.
-
GC66088
α-Helical CRF(9-41) TFA
α-Helical CRF(9-41) TFA is a competitive CRF2 receptor antagonist with KB of ~100 nM. α-Helical CRF(9-41) TFA is also a partial agonist of CRF1 receptor with an EC50 of 140 nM.
-
GC66030
CB1 agonist 1
CB1 agonist 1 (compound 22) is an agonist of CB1. CB1 agonist 1 shows affinity to CB1 receptor with an pIC50 value of 5.7. CB1 agonist 1 can be used for the research of brain disorders.
-
GC66025
Angiotensin III, human, mouse TFA
Angiotensin III, human, mouse (TFA) is an angiotensin.
-
GC66020
ZINC69391
ZINC69391, a specific Rac1 inhibitor, interferes with Rac1-GEF interaction by masking Trp56 residue on Rac1 surface. ZINC69391 interferes with the interaction of Rac1 with Dock180 and reduces Rac1-GTP levels. ZINC69391 induces apoptosis, and shows antiproliferative and antimetastatic effects.
-
GC66007
Adenosine receptor antagonist 3
Adenosine receptor antagonist 3 is a potent antagonist of adenosine receptor. Adenosine receptor antagonist 3 has the potential for the research of cancer disease (extracted from patent WO2019233994A1, compound 1).
-
GC66001
RBC10
RBC10 is an anti-cancer agent. RBC10 inhibits the binding of Ral to its effector RALBP1. RBC10 also inhibits Ral-mediated cell spreading of murine embryonic fibroblasts and anchorage-independent growth of human cancer cell lines.
-
GC65990
MLN3126
MLN3126 is an orally active and potent CCR9 antagonist. MLN3126 inhibits CCL25-induced calcium mobilization and chemotaxis of mouse primary thymocytes, wiht an IC50 value of 6.3 nM for calcium influx.
-
GC65987
EP3 antagonist 3
EP3 antagonist 3 (compound 2) is an orally active, potent and selective EP3 antagonist, with a pKi of 8.3. EP3 antagonist 3 shows excellent pharmacokinetic properties. EP3 antagonist 3 can be used for overactive bladder (OAB) research.
-
GC65986
SAE-14
SAE-14 (compound SAE-14) is a potent, specific GPR183 antagonist with an IC50 value of 28.5 nM, can antagonize 7α, 25-OHC-induced calcium mobilization with IC50 value below 50 nM in HL-60 cells. GPR183 antagonist-1 can reverse allodynia in mice.
-
GC65983
5-HT3 antagonist 5
5-HT3 antagonist 5 is a quinoxalin-2-carboxamide compound, a 5-HT3 receptor antagonist. 5-HT3 antagonist 5 exerts antagonism on 5-HT3 agonist and 2-methyl-5-HT, and shows anti-depressant effect in mice.
-
GC65971
L-Glutamine-13C5
L-Glutamine-13C5 (L-Glutamic acid 5-amide-13C5) is the 13C-labeled L-Glutamine. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells.
-
GC65955
Denopamine
Denopamine ((R)-(-)-Denopamine) is an orally active, selective β1-adrenergic agonist. Denopamine prolongs survival in a murine model of congestive heart failure induced by viral myocarditis: suppression of tumor necrosis factor-α production in the heart. Cardiovascular effects.
-
GC65946
VA-K-14 hydrochloride
VA-K-14 hydrochloride is a specific thyroid-stimulating hormone receptor (TSHR) antagonist (IC50= 12.3 μM).
-
GC65910
SAR247799
SAR247799 (S1P1 agonist 3) is an oral activity, selective G-protein-biased sphingosine-1 phosphate receptor-1 (S1P1 ) agonist, with EC50s rang from 12.6 to 493 nM in S1P1-overexpressing cells and HUVECs. SAR247799 can be used for the research of endothelial protection, including type-2 diabetes, metabolic syndrome.
-
GC65908
CXCR2 antagonist 2
CXCR2 antagonist 2 is a potent CXCR2 antagonist for cancer immunotherapy with an IC50 value of 95 nM.
-
GC65904
KRAS G12C inhibitor 28
KRAS G12C inhibitor 28 is a KRAS G12C inhibitor with an IC50 of 57 nM. KRAS G12C inhibitor 28 has antitumor effects (WO2021113595A1; Example 1).
-
GC65901
Adenosine receptor antagonist 2
Adenosine receptor antagonist 2 is an orally active A2a/A2b adenosine receptor antagonist with IC50s of 1 nM and 3 nM, respectively. Adenosine receptor antagonist 2 has anti-tumor activity.
-
GC65893
Tildacerfont
Tildacerfont is a potent and orally active corticotrophin-releasing factor type 1 (CRF1) receptort antagonis. Tildacerfont effectively reduces adrenocorticotropic hormone (ACTH) and adrenal androgen levels. Tildacerfont has favourable safety profile. Tildacerfont can be used for researching congenital adrenal hyperplasia.
-
GC65874
Medroxalol
Medroxalol (RMI81968) is an orally active adrenergic receptor antagonist, blocks α- and β-adrenergic receptors. Medroxalol shows antihypertensive and vasodilating effects.
-
GC65873
SOS1-IN-14
SOS1-IN-14 is a potent, selective and orally active SOS1 inhibitor with an IC50 value of 3.9 nM. SOS1-IN-14 can be absorbed in the intestine via a P-glycoprotein-mediated efflux mechanism. SOS1-IN-14 can be used to research KRAS-mutated cancers. SOS1-IN-14 has better potent tumor suppression than BI-3406 (HY-125817).
-
GC65614
Ticlopidine hydrochloride
Ticlopidine hydrochloride is an adenosine diphosphate (ADP) receptor inhibitor against platelet aggregation with IC50 of ~2 μM.
-
GC65579
ONO-0300302
ONO-0300302 is an orally active and potent LPA1 (lysophosphatidic acid receptor 1) antagonist, with an IC50 of 0.086 μM.
-
GC65568
5-HT2B antagonist-1
5-HT2B antagonist-1 is an orally active 5-HT2B receptor antagonist with an IC50 value of 33.4 nM.
-
GC65567
M4 mAChR agonist-1
M4 mAChR agonist-1 (compound 10a) is a potent M4 mAChR agonist with an EC50 >10 μM for human M4.
-
GC65565
Cyproheptadine
Cyproheptadine is a potent and orally active 5-HT2A receptor antagonist, with antidepressant and antiserotonergic effects.
-
GC65550
Danavorexton
Danavorexton is an orexin receptor agonist.
-
GC65504
L-Hyoscyamine-d3
-
GC65480
ARS-1323-alkyne
ARS-1323-alkyne, a switch-II pocket (S-IIP) inhibitor, is a conformational specific chemical reporter of KRASG12C nucleotide state in living cells.
-
GC65476
CXCR7 antagonist-1 hydrochloride
CXCR7 antagonist-1 hydrochloride is a CXCR7 antagonist that inhibits the binding of the SDF-1 chemokine (also known as the CXCL12 chemokine) or I-TAC (also known as CXCL11) to the chemokine receptor CXCR7.
-
GC65450
CT1812
CT1812 (Sigma-2 receptor antagonist 1) is a sigma-2 (σ-2) receptor antagonist.
-
GC65415
Felypressin acetate
Felypressin acetate (PLV-2 acetate) is a non-catecholamine vasoconstrictor and a vasopressin 1 agonist.
-
GC65389
Auglurant
Auglurant (VU0424238) is a novel and selective mGlu5 antagonist with an IC50 value of 11 nM (rat) and an IC50 value of 14 nM (human).
-
GC65382
Orexin receptor antagonist 5
-
GC65379
Guvacoline hydrochloride
Guvacoline hydrochloride, a pyridine alkaloid found in Areca triandra, can act as a weak full agonist of atrial and ileal muscarinic receptors.
-
GC65370
ORIC-101
ORIC-101 is a highly potent and selective glucocorticoid receptor antagonist, with an EC50 of 5.6 nM.
-
GC65345
BI 653048
BI 653048 is a selective and orally active nonsteroidal?glucocorticoid (GC)?agonist with an IC50 value of 55 nM.
-
GC65324
RP101988
RP101988, the major active metabolite of Ozanimod, is a selective, potent S1PR1 (sphingosine-1-phosphate receptor 1) agonist, with EC50s of 0.19 nM and 32.8 nM for S1PR1 and S1PR5, respectivlely.
-
GC65317
EP2 receptor antagonist-1
EP2 receptor antagonist-1 (compound 1) is a potent, reversible, and agonist dependent allosteric prostaglandin EP2 receptor antagonist.
-
GC65313
SSTR5 antagonist 1
SSTR5 antagonist 1 is a potent, selective, and orally available somatostatin receptor subtype 5 (SSTR5) antagonist with IC50s of 9.6 and 57 nM for hSSTR5 and mSSTR5, respectively.
-
GC65296
Pimethixene maleate
Pimethixene maleate is antihistamine and antiserotonergic compound, acts as an antimigraine agent.
-
GC65277
Tedalinab
Tedalinab (GRC-10693) is a potent, orally active, and selective cannabinoid receptor 2 (CB2) agonist.
-
GC65276
Tasipimidine sulfate
Tasipimidine sulfate is an orally active and selective α2A-adrenoceptor agonist with a pEC50 of 7.57 against human α2A-adrenoceptor.
-
GC65270
Digeranyl bisphosphonate
Digeranyl bisphosphonate (DGBP) is a potent geranylgeranylpyrophosphate (GGPP) synthase inhibitor, which inhibits geranylgeranylation of Rac1.