GLPBio

BZ1

Catalog No.: GC25183Purity:>98%Synonyms: BPTF inhibitor, BPTF-IN-BZ1
BZ1 (BPTF inhibitor, BPTF-IN-BZ1) is a pyridazinone-based BPTF (Bromodomain PHD Finger Transcription Factor) inhibitor with a high potency (Kd = 6.3 nM) and >350-fold selectivity over BET bromodomains.

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BZ1
Cas No.: 2766623-38-3
5mgIn Stock
$275.00
1
25mgIn Stock
$824.00
1

Citations

No citations are currently available for this product. Below are selected publications citing GlpBio products.
  • Nature cover
    Nature
    641, 529–536 (2025)
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    Nature
    628, 630–638 (2024)
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    Nature
    632, 686–694 (2024)
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    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
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    Science
    388(6745) (2025)
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    387(6739) (2025)
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    Science
    387(6734) (2025)
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    Cell Research
    35, 97–116 (2025)
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    Cell Research
    34, 683–706 (2024)
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    Cell Research
    33, 273–287 (2023)
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    33, 546–561 (2023)
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    33, 904–922 (2023)
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    Cell Research
    31, 1291–1307 (2021)

Description

BZ1 (BPTF inhibitor, BPTF-IN-BZ1) is a pyridazinone-based BPTF (Bromodomain PHD Finger Transcription Factor) inhibitor with a high potency (Kd = 6.3 nM) and >350-fold selectivity over BET bromodomains.

[1] Zahid H, et al. J Med Chem. 2021 Sep 23;64(18):13902-13917.

Chemical Properties

CAS No.
2766623-38-3
Synonyms
BPTF inhibitor, BPTF-IN-BZ1
Molecular Formula
C13H15ClN4O
Molecular Weight
278.74
Solubility
DMSO: 56 mg/mL (200.90 mM);Water: Insoluble;Ethanol: Insoluble
Storage
Store at -20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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