Carbaryl (Synonyms: Arylam, Dyna-carbyl, ENT 23969, NSC-27311, UC-7744, α-Naphthalenyl methyl Carbamate, α-Naphthyl methyl Carbamate) |
Catalog No.GC47036
One-Click Copy Product Info
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A carbamate insecticide
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 63-25-2
Sample solution is provided at 25 µL, 10mM.
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Carbaryl is a carbamate insecticide that inhibits acetylcholinesterase (AChE; IC50 = 13.6 nM for A. gambiae AChE2 expressed in Sf9 cells; Ki = 5.7 µM for rat brain AChE).1,2 Carbaryl administered at a dose of 30 mg/kg for 28 days in rats decreases the weight of spleen and thymus, proliferation of lymphocytes, and serum levels of IL-2, IFN-γ, IL-1β, and TNF-α, and increases the serum levels of IL-4 and IL-10.3 It increases CaMKII, GAP-43, and tau protein levels in the hippocampus and tau levels in the cortex of mice 24 hours after administration of doses ranging from 0.5 to 20 mg/kg on postnatal day ten, whereas tau protein levels are decreased four months after administration with no change in CaMKII or GAP-43 compared with control mice. These effects occur at non-toxic doses where acetylcholinesterase is inhibited only during the first six hours following treatment. Formulations containing carbaryl have been used to control insects in agriculture.
1.Zhao, P., Wang, Y., and Jiang, H.Biochemical properties, expression profiles, and tissue localization of orthologous acetylcholinesterase-2 in the mosquito, Anopheles gambiaeInsect. Biochem. Mol. Biol.43(3)260-271(2013) 2.Hassan, A., Abdel-Hamid, F.M., and Bahig, M.R.E.Kinetics of inhibition of rat brain acetylcholinesterase by SevinZ. Naturforsch. B.22(5)505-507(1967) 3.Jorsaraei, S.G., Maliji, G., Azadmehr, A., et al.Immunotoxicity effects of carbaryl in vivo and in vitroEnviron. Toxicol. Pharmacol.38(3)838-844(2014)
| Cas No. | 63-25-2 | SDF | |
| Synonyms | Arylam, Dyna-carbyl, ENT 23969, NSC-27311, UC-7744, α-Naphthalenyl methyl Carbamate, α-Naphthyl methyl Carbamate | ||
| Canonical SMILES | O=C(NC)OC1=C2C(C=CC=C2)=CC=C1 | ||
| Formula | C12H11NO2 | M.Wt | 201.2 |
| Solubility | DMSO : 100 mg/mL (496.97 mM; Need ultrasonic) | Storage | Store at RT |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 4.9702 mL | 24.8509 mL | 49.7018 mL |
| 5 mM | 994 μL | 4.9702 mL | 9.9404 mL |
| 10 mM | 497 μL | 2.4851 mL | 4.9702 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.50% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 37 reference(s) in Google Scholar.)