GLPBio

CAY10756

Catalog No.: GC47058Purity:>99.50%
COASDSData Sheet
An inhibitor of ASK1

Products are for research use only. Not for human use. We do not sell to patients.

CAY10756
Cas No.: 2411382-24-4
1mgIn Stock
$134.00
1
5mgIn Stock
$513.00
1
10mgIn Stock
$345.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

Citations

No citations are currently available for this product. Below are selected publications citing GlpBio products.
  • Nature cover
    Nature
    641, 529–536 (2025)
  • Nature cover
    Nature
    628, 630–638 (2024)
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    Nature
    632, 686–694 (2024)
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    Nature
    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
  • Science cover
    Science
    388(6745) (2025)
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    Science
    387(6739) (2025)
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    Science
    387(6734) (2025)
  • Cell Research cover
    Cell Research
    35, 97–116 (2025)
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    Cell Research
    34, 683–706 (2024)
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    Cell Research
    33, 273–287 (2023)
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    Cell Research
    33, 546–561 (2023)
  • Cell Research cover
    Cell Research
    33, 904–922 (2023)
  • Cell Research cover
    Cell Research
    31, 1291–1307 (2021)

Description

CAY10756 is a brain-penetrant inhibitor of apoptosis signal-regulating kinase 1 (ASK1; IC50 = 21 nM).1 It inhibits autophosphorylation of ASK1 in HEK293T cells (IC50 = 138 nM).

1.Xin, Z., Himmelbauer, K., Jones, J.H., et al.Discovery of CNS-penetrant apoptosis signal-regulating kinase 1 (ASK1) inhibitorsACS Med. Chem. Lett.11(4)485-490(2020)

Product Documents

Purity:>99.50%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
2411382-24-4
SMILES
O=C(C1=CN(C2=NC=CN=C2)N=C1OC)NC3=CC=CC(C4=NN=CN4C(C)C)=N3
Molecular Formula
C19H19N9O2
Molecular Weight
405.4
Solubility
Chloroform: 10 mg/ml
Storage
Store at -20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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