GLPBio

CCKBR agonist-2

Catalog No.: GC79283Purity:>99.50%
COASDSData Sheet
CCKBR agonist-2 (Compound z-44) is a Gi-preferring CCKBR agonist.

Products are for research use only. Not for human use. We do not sell to patients.

CCKBR agonist-2
Cas No.: 923714-61-8
10mM (in 1mL DMSO)In Stock
$63.00
1
5mgIn Stock
$57.00
1
10mgIn Stock
$92.00
1
25mgIn Stock
$180.00
1
50mgIn Stock
$287.00
1
100mgIn Stock
$459.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

Citations

No citations are currently available for this product. Below are selected publications citing GlpBio products.
  • Nature cover
    Nature
    641, 529–536 (2025)
  • Nature cover
    Nature
    628, 630–638 (2024)
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    Nature
    632, 686–694 (2024)
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    Nature
    618, 1017–1023 (2023)
  • Nature cover
    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
  • Science cover
    Science
    388(6745) (2025)
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    Science
    387(6739) (2025)
  • Science cover
    Science
    387(6734) (2025)
  • Cell Research cover
    Cell Research
    35, 97–116 (2025)
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    Cell Research
    34, 683–706 (2024)
  • Cell Research cover
    Cell Research
    33, 273–287 (2023)
  • Cell Research cover
    Cell Research
    33, 546–561 (2023)
  • Cell Research cover
    Cell Research
    33, 904–922 (2023)
  • Cell Research cover
    Cell Research
    31, 1291–1307 (2021)

Description

CCKBR agonist-2 (Compound z-44) is a Gi-preferring CCKBR agonist. CCKBR agonist-2 effectively activates the CCKBR-Gi signaling pathway ( EC 50 = 0.27 nM), but has almost no activity on Gq and Gs signaling pathways. CCKBR agonist-2 shows no significant protective effect in the mouse Alzheimer's disease model, proving that the simple activation of the Gi signal pathway does not play a dominant role in the improvement of cognitive function [1].

References:
[1]. Wang JL, et al. Elucidating pathway-selective biased CCKBR agonism for Alzheimer's disease treatment. Cell. 2025 Nov 20:S0092-8674(25)01238-3.

Product Documents

Purity:>99.50%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
923714-61-8
Molecular Formula
C15H15NO4
Molecular Weight
273.28
Solubility
DMSO: 100 mg/mL (365.93 mM; Need ultrasonic)
Storage
Store at -20°C
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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