GLPBio

COTC

Catalog No.: GC52018Purity:>90.00%Synonyms: 2-Crotonyloxymethyl-(4R,5R,6R)-4,5,6-trihydroxycyclohex-2-enone
COASDSData Sheet
A bacterial metabolite with anticancer activity

Products are for research use only. Not for human use. We do not sell to patients.

COTC
Cas No.: 57449-30-6
1 mgIn Stock
$1,309.00
1
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Citations

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  • Nature cover
    Nature
    641, 529–536 (2025)
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    628, 630–638 (2024)
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    Nature
    632, 686–694 (2024)
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    Nature
    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
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    Science
    388(6745) (2025)
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    387(6739) (2025)
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    Science
    387(6734) (2025)
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    Cell Research
    35, 97–116 (2025)
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    34, 683–706 (2024)
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    33, 273–287 (2023)
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    33, 546–561 (2023)
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    33, 904–922 (2023)
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    Cell Research
    31, 1291–1307 (2021)

Description

COTC is a bacterial metabolite that has been found in S. griseosporeus and has anticancer activity.1 It inhibits glyoxalase in the presence of glutathione (GSH) in a concentration- and time-dependent manner. COTC inhibits the proliferation of HeLa cells (IC50 = 18 µg/ml), as well as reduces tumor growth and improves survival in an Ehrlich murine spontaneous adenocarcinoma model.

1.Takeuchi, T., Chimura, H., Hamada, M., et al.A glyoxalase I inhibitor of a new structural type produced by StreptomycesJ. Antibiot. (Tokyo)28(1)737-742(1975)

Product Documents

Purity:>90.00%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
57449-30-6
Synonyms
2-Crotonyloxymethyl-(4R,5R,6R)-4,5,6-trihydroxycyclohex-2-enone
SMILES
CC=CC(OCC1=C[C@@H](O)[C@@H](O)[C@@H](O)C1=O)=O
Molecular Formula
C11H14O6
Molecular Weight
242.2
Solubility
DMSO: soluble,Methanol: soluble,Water: soluble
Storage
-20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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