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COTC (Synonyms: 2-Crotonyloxymethyl-(4R,5R,6R)-4,5,6-trihydroxycyclohex-2-enone)

Catalog No.GC52018

A bacterial metabolite with anticancer activity

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COTC Chemical Structure

Cas No.: 57449-30-6

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1 mg
$1,309.00
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

COTC is a bacterial metabolite that has been found in S. griseosporeus and has anticancer activity.1 It inhibits glyoxalase in the presence of glutathione (GSH) in a concentration- and time-dependent manner. COTC inhibits the proliferation of HeLa cells (IC50 = 18 µg/ml), as well as reduces tumor growth and improves survival in an Ehrlich murine spontaneous adenocarcinoma model.

1.Takeuchi, T., Chimura, H., Hamada, M., et al.A glyoxalase I inhibitor of a new structural type produced by StreptomycesJ. Antibiot. (Tokyo)28(1)737-742(1975)

Chemical Properties

Cas No. 57449-30-6 SDF Download SDF
Synonyms 2-Crotonyloxymethyl-(4R,5R,6R)-4,5,6-trihydroxycyclohex-2-enone
Canonical SMILES CC=CC(OCC1=C[C@@H](O)[C@@H](O)[C@@H](O)C1=O)=O
Formula C11H14O6 M.Wt 242.2
Solubility DMSO: soluble,Methanol: soluble,Water: soluble Storage -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 4.1288 mL 20.6441 mL 41.2882 mL
5 mM 0.8258 mL 4.1288 mL 8.2576 mL
10 mM 0.4129 mL 2.0644 mL 4.1288 mL
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Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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