CpdA (Synonyms: Compound A) |
| Catalog No.GC18258 |
CpdA is a non-steroidal selective glucocorticoid receptor modulator.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 14593-25-0
Sample solution is provided at 25 µL, 10mM.
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CpdA is a non-steroidal selective glucocorticoid receptor modulator. It is an aziridine precursor that can infiltrate cells and is translocated to the nucleus. It inhibits glucocorticoid receptor dimerization, which prevents transcription of gene targets such as NF-κB and subsequent cytokines through transrepression. Studies have shown contradictory results for binding affinity of CpdA compared with dexamethasone that were either higher (4-fold, IC50 = 6.4 nM and 25.9 nM, respectively, in L929sA cells) or lower (63-fold, Kd = 81.8 nM and 1.29 nM, respectively, in BWTG3 cells) in whole cell binding assays.
Review for CpdA
Average Rating: 5 (Based on Reviews and 37 reference(s) in Google Scholar.)
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