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phosphatases

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Phosphatases are enzyme that remove a phosphate group from a protein. Protein tyrosine phosphatases (PTPs) comprise a diverse family of transmembrane and cytoplasmic enzymes. PTPs play an important role in regulating the proliferative activity of cells and the integrity of cell-cell and cell-matrix contacts. Protein tyrosine phosphatase 1B (PTP1B) is a non-receptor PTP frequently associated with the endoplasmic reticulum and vesicles subjacent to the plasma membrane. PTP1B as a key negative regulator of leptin receptor pathways has been an attractive therapeutic target for the treatment of type 2 diabetes mellitus and obesity. Four major serine/threonine-specific protein phosphatase catalytic subunits are present in the cytoplasm of animal cells. Three of these enzymes, PP1, PP2A, and PP2B, are members of the same gene family, while PP2C appears to be distinct.The alkaline phosphatases comprise a heterogeneous group of enzymes that are widely distributed in mammalian cells. Acid phosphatase enzymes catalyze the hydrolysis of phosphate monoesters following the general equation.

Products Related to phosphatases(102)

  • GC10019 structure
    GC10019SF1670
    CAS: 345630-40-2
    Purity: >98.00%

    SF1670 is a potent and specific PTEN (phosphatase and tensin homolog deleted on chromosome 10) inhibitor.

  • GC10169 structure
    GC10169NSC 87877
    CAS: 56990-57-9
    Purity: >98.00%

    A potent inhibitor of SHP-1 and SHP-2

  • GC10594 structure
    GC10594sodium fluoride
    CAS: 7681-49-4
    Purity: >99.00%

    Sodium Fluoride, another form of fluorine, is orally bioavailable and can accumulate in reproductive organs and interfere with hormonal regulation and oxidative stress pathways, contributing to reproductive toxicity.

  • GC10850 structure
    GC10850ML-095 (hydrochloride)
    CAS: 1135318-57-8
    Purity: >98%

    ML-095 (hydrochloride) is a biochemical inhibitor of PLAP.

  • GC11352 structure
    GC11352Tetramisole HCl
    CAS: 5086-74-8
    Purity: >99.00%

    Tetramisole HCl is an inhibitor of alkaline phosphatases, is a high purity antiparasitic.

  • GC11561 structure
    GC11561NSC 95397
    CAS: 93718-83-3
    Purity: >98.00%

    Cdc25 dual specificity phosphatases inhibitor

  • GC11806 structure
    GC11806β-Glycerophosphate (sodium salt hydrate)
    CAS: 13408-09-8
    Purity: >98.00%

    β-Glycerophosphate (sodium salt hydrate) is a phosphatase inhibitor.

  • GC12020 structure
    GC12020TCS 401
    CAS: 243966-09-8
    Purity: >98.00%

    A selective PTP1B inhibitor

  • GC12093 structure
    GC12093Sodium tartrate
    CAS: 868-18-8
    Purity: >98.00%

    Acid phosphatases inhibitor

  • GC12189 structure
    GC12189LB-100
    CAS: 1026680-07-8
    Purity: >98%

    protein phosphatase 2A(PP2A)inhibitor

  • GC12306 structure
    GC12306Imidazole
    CAS: 288-32-4
    Purity: >99.50%

    Alkaline phosphatases inhibitor

  • GC12880 structure
    GC12880GSK 2830371
    CAS: 1404456-53-6
    Purity: >98.50%

    Orally active, allosteric inhibitor of Wip1 phosphatase

  • GC13516 structure
    GC13516AS 1949490
    CAS: 1203680-76-5
    Purity: >98.00%

    Selective SHIP2 inhibitor

  • GC13941 structure
    GC13941Cyclosporin A
    CAS: 59865-13-3
    Purity: >99.00%

    Cyclosporin A is an immunosuppressive agent which has three major cellular targets including cyclophilins, calcineurin and transporters while it can inhibit the activity of cyclophilin A and calcineurin with an IC 50 of 360nM and 5nM.

  • GC14321 structure
    GC14321Sal 003
    CAS: 1164470-53-4
    Purity: >99.50%

    Sal 003 is a potent and cell-permeable inhibitor of the eIF2α phosphatase that inhibits dephosphorylation of eIF2α.

  • GC14368 structure
    GC14368Sodium Orthovanadate
    CAS: 13721-39-6
    Purity: >99.00%

    PTP inhibitor

  • GC14520 structure
    GC14520(-)-p-Bromotetramisole Oxalate
    CAS: 62284-79-1
    Purity: >99.00%

    (-)-p-Bromotetramisole Oxalate(L-p-bromotetramisole) is a potent and non-specific inhibitor of alkaline phosphatase.

  • GC14875 structure
    GC14875NSC 663284
    CAS: 383907-43-5
    Purity: >99.50%

    Cdc25 dual specificity phosphatases inhibitor

  • GC16233 structure
    GC16233Tacrolimus (FK506)
    CAS: 104987-11-3
    Purity: >98.00%

    Tacrolimus (FK506), a macrolide antibiotic with potent immunosuppressive effects was isolated from Streptomyces tsukubaensis and has been previously used to prevent allograft and for treatment of autoimmune disorders in humans.

  • GC16256 structure
    GC16256BVT 948
    CAS: 39674-97-0
    Purity: >98.50%

    An inhibitor of protein tyrosine phosphatases

  • GC16396 structure
    GC16396Sodium molybdate
    CAS: 7631-95-0
    Purity: >98%

    Acid and phosphoprotein phosphatases inhibitor

  • GC16451 structure
    GC16451L-690330
    CAS: 142523-38-4
    Purity: >98.00%

    competitive inhibitor of inositol monophosphatase (IMPase)

  • GC17331 structure
    GC17331Salubrinal
    CAS: 405060-95-9
    Purity: >99.50%

    Salubrinal is a potent and selective inhibitor of eukaryotic translation initiation factor 2α (eIF2α) dephosphorylation.

  • GC17591 structure
    GC17591D-erythro-Sphingosine (synthetic)
    CAS: 123-78-4
    Purity: >98.00%

    D-erythro-Sphingosine (synthetic) is a bioactive activator of p32 kinase (EC 50 =8μM).