GLPBio

Cyclic di-UMP (sodium salt)

Catalog No.: GC48397Purity:>95.00%Synonyms: c-di-UMP, c-UpUp, Cyclic di-Uridine monophosphate, 3’3’-Cyclic UMP-UMP
COASDSData Sheet
A pyrimidine-containing CDN

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Cyclic di-UMP (sodium salt)
600µgIn Stock
$373.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

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    187(9):2288-2304 (2024)
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Description

Cyclic di-UMP is a pyrimidine-containing cyclic dinucleotide (CDN).1 It is produced by bacterial cGAS/DncV-like nucleotidyltransferases (CD-NTases), such as LpCdnE02 from L. pneumophila, and binds to cGAS, in the apo or dsDNA-bound forms, with reduced affinity compared to 2'3'-cGAMP or 3'3'-cGAMP .1,2 Cyclic di-UMP is intended for use as a negative control for cyclic di-GMP signaling.

1.Whiteley, A.T., Eaglesham, J.B., de Oliveira Mann, C.C., et al.Bacterial cGAS-like enzymes synthesize diverse nucleotide signalsNature564(7747)194-199(2019) 2.Hall, J., Ralph, E.C., Shanker, S., et al.The catalytic mechanism of cyclic GMP-AMP synthase (cGAS) and implications for innate immunity and inhibitionProtein Sci.26(12)2367-2380(2017)

Product Documents

Purity:>95.00%Appearance:A solid
COASDSData Sheet

Chemical Properties

Synonyms
c-di-UMP, c-UpUp, Cyclic di-Uridine monophosphate, 3’3’-Cyclic UMP-UMP
SMILES
[O-]P1(OC[C@@]2([H])O[C@](N3C=CC(NC3=O)=O)([H])[C@H](O)[C@@]2(OP([O-])(OC[C@]([H])([C@]4(O1)[H])O[C@](N5C=CC(NC5=O)=O)([H])[C@@H]4O)=O)[H])=O.[Na+].[Na+]
Molecular Formula
C18H20N4O16P2•2Na
Molecular Weight
656.3
Solubility
Water: soluble
Storage
-20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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